Medicine and Health Sciences Commons^™

Preclinical Development Of Novel Chemotherapeutic Agent Ac1lpszg: Formulation Optimization, In Vitro Characterization, And In Vivo Pharmacokinetics, Ritu Gupta

Dissertations (2016-Present)

Preclinical development of novel chemotherapeutic agent AC1LPSZG, a mammalian target of rapamycin (mTOR) inhibitor, involved development of sensitive reverse-phase ultra-performance liquid chromatography (UPLC) and LC-MS/MS methods for quantification of AC1LPSZG in in vitro study samples and rat plasma, respectively. Pharmacokinetic studies were done in SD rats after intravenous injection of cosolvent formulations. The resulting pharmacokinetic parameters were analyzed using non-compartmental analysis (NCA) and two-compartmental modeling. Poly (D, L-lactic-co-glycolic acid) (PLGA) is most used biodegradable synthetic polymer for nano drug delivery due to its non-toxic and biodegradable nature, and tunable release properties. PLGA nanoparticles (NPs) were prepared by ‘nanoprecipitation’ technique using …

Screening Tcf19 And Kif18b To Determine Co-Regulation With Mybl1 In Triple Negative Breast Cancer Patient Tissues, Tyra Sharda Ivory

Theses (2016-Present)

The aggressive behavior in triple-negative breast cancer (TNBC) is due to genetic signaling events, which call for the comprehensive analyses of genes differentially regulated in the cancers. Our laboratory previously found that MYBL1 was over-expressed in a fraction of the TNBC, compared to some luminal, and other breast cancer subtypes. The MYBL1 gene is a proto-oncogene that serves as a strong transcriptional activator. The gene is involved in signaling events related to cell cycle signaling, differentiation, proliferation, and apoptosis, all which are differentially regulated in cancers. Because MYBL1 is a transcription regulator, involved in cancer-related mechanisms and differentially expressed in …

Review Of The Latest Trends In Transplantation Immunology And Its Role In Mortality Reduction, Vivian Adedoye

Honor’s College Freeman Research Journal

Transplantation immunology deals with the process of moving cells, tissues, or organs, from one site to another, either within the same person or between a donor and a recipient. If an organ system fails, or becomes damaged because of disease or injury, it can be replaced with a healthy organ or tissue from a donor. The process of transplantation has become increasingly popular due to its life saving benefit. In 2015 /2016 4601 patients' lives were saved or improved by an organ transplant in the United Kingdom alone. Kidney transplants are the most common organ transplant followed by liver and …

Inhibition Of Serine, Glycine, One-Carbon Metabolism Reduces Proinflammatory Response, Ashlynn Mccall

Honor’s College Freeman Research Journal

Acute lung injury affects around 200,000 critically ill patients annually, with a mortality rate near 33%. With a lack of targeted therapies, it is vital to discover and understand the fundamental cellular processes that drive macrophage inflammation. In the field of macrophage immunometabolism, it is accepted that macrophages upregulating glycolysis indicates a role in proinflammatory processes, however, there is a lack of knowledge surrounding the intermediate pathways in glycolysis. This study examined the effects of serine, glycine, one-carbon metabolism inhibition on LPS-induced inflammation in bone marrow-derived macrophages. We show that the enzymatic expression of PHGDH and PSATl is unaffected when …

Tsu Faculty Research Database-Jan 2017, David Owerbach

Office of Research Institutional Research and Scholarship

Research interests and selected publications from 230 Texas Southern University faculty have been updated in Jan 2017. Faculty from Public Affairs, the College of Science, Engineering and Technology, the College of Pharmacy and Health Sciences, the College of Education, the College of Business, the College of Liberal Arts and Behavioral Sciences, the Law School and the School of Communications are included.

2016 Research Week, Linda Gardiner, David Owerbach

Office of Research Institutional Research and Scholarship

RESEARCH WEEK 2016 TABLE OF CONTENTS

ADMINISTRATION RESEARCH COMMITTEES ACTIVITY SCHEDULE

LETTERS OF ENDORSEMENT

GENERAL SESSION

FACULTY, STAFF, AND STUDENT POSTER PRESENTATIONS

FACULTY AND STUDENT ORAL PRESENTATIONS

Research Week 2015, Linda Gardiner, David Owerbach

Office of Research Institutional Research and Scholarship

No abstract provided.

Faculty Research Interest Database, David Owerbach

Office of Research Institutional Research and Scholarship

No abstract provided.

Tsu Faculty Publication Database, David Owerbach

Office of Research Institutional Research and Scholarship

No abstract provided.

2014 Tsu Undergraduate Research Program, David Owerbach

Office of Research Institutional Research and Scholarship

No abstract provided.

Research Week 2014, Linda Gardiner

Office of Research Institutional Research and Scholarship

No abstract provided.

2013 Tsu Undergraduate Research Program, David Owerbach

Office of Research Institutional Research and Scholarship

No abstract provided.

Research Week 2013, Linda Gardiner

Office of Research Institutional Research and Scholarship

No abstract provided.

Behavioral Changes For African Americans To Improve Health, Embrace Culture, And Minimize Disparities, Dashiel J. Geyen Ed.D., M.P.H.

The Bridge: Interdisciplinary Perspectives on Legal & Social Policy

In spite of significant advances in the prevention, diagnoses, and treatment of most chronic diseases, there is evidence that racial and ethnic people of color tend to receive lower quality of care and less preventive interventions than the majority members of a community. While our health system should improve its efforts at addressing and reducing disproportionality in health care, African Americans can make behavioral changes through diet and exercise that will reduce their susceptibility to chronic illnesses. This article first reviews the prevalence, disparities, and characteristics of chronic diseases impacting the African American population. Second, it discusses culturally connected practices …

2012 Tsu Undergraduate Research Program, David Owerbach

Office of Research Institutional Research and Scholarship

No abstract provided.

Research Week 2012, Linda Gardiner

Office of Research Institutional Research and Scholarship

No abstract provided.

A Healthy Home For Everyone: The Guide For Families And Individuals, Center For Disease Control And Prevention, Atlanta Ga

Mickey Leland Center Information Portal

The purpose of this booklet is to provide information about the connection between housing and health. You will find action steps for making your home healthy, definitions for words used in the booklet, and a resource section to find more information about a making your home a healthy home.