Medicine and Health Sciences Commons^™

Screening Tcf19 And Kif18b To Determine Co-Regulation With Mybl1 In Triple Negative Breast Cancer Patient Tissues, Tyra Sharda Ivory

Theses (2016-Present)

The aggressive behavior in triple-negative breast cancer (TNBC) is due to genetic signaling events, which call for the comprehensive analyses of genes differentially regulated in the cancers. Our laboratory previously found that MYBL1 was over-expressed in a fraction of the TNBC, compared to some luminal, and other breast cancer subtypes. The MYBL1 gene is a proto-oncogene that serves as a strong transcriptional activator. The gene is involved in signaling events related to cell cycle signaling, differentiation, proliferation, and apoptosis, all which are differentially regulated in cancers. Because MYBL1 is a transcription regulator, involved in cancer-related mechanisms and differentially expressed in …

Preclinical Development Of Novel Chemotherapeutic Agent Ac1lpszg: Formulation Optimization, In Vitro Characterization, And In Vivo Pharmacokinetics, Ritu Gupta

Dissertations (2016-Present)

Preclinical development of novel chemotherapeutic agent AC1LPSZG, a mammalian target of rapamycin (mTOR) inhibitor, involved development of sensitive reverse-phase ultra-performance liquid chromatography (UPLC) and LC-MS/MS methods for quantification of AC1LPSZG in in vitro study samples and rat plasma, respectively. Pharmacokinetic studies were done in SD rats after intravenous injection of cosolvent formulations. The resulting pharmacokinetic parameters were analyzed using non-compartmental analysis (NCA) and two-compartmental modeling. Poly (D, L-lactic-co-glycolic acid) (PLGA) is most used biodegradable synthetic polymer for nano drug delivery due to its non-toxic and biodegradable nature, and tunable release properties. PLGA nanoparticles (NPs) were prepared by ‘nanoprecipitation’ technique using …

Preclinical Development Of A Novel Antileishmanial Agent Ojt007: Bioanalytical Assay, In Vitro Studies And Pharmacokinetics, Maria Eugenia Rincon-Nigro

Dissertations (2016-Present)

Current treatments for cutaneous leishmaniasis suffer from toxic side effects, high cost, parenteral administration, and drug resistance. Thus, there is a critical need to develop oral drugs for the treatment of leishmaniasis. OJT007 is a novel class of drug with potent antiproliferative effects against Leishmania Major. The purpose of this project is to conduct preclinical drug development studies for OJT007 including bioanalytical assay development, pre-formulation studies, in vitro hepatic drug metabolism and in vivo pharmacokinetics. A sensitive, specific, and reproducible ultra-high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated. The separation was achieved on a UPLC BEH …

Discovery Of Ojt008 As A Novel Inhibitor Of Mycobacterium Tuberculosis, Collins Chidi Onyenaka

Dissertations (2016-Present)

Despite recent progress in the diagnosis of Tuberculosis (TB), the chemotherapeutic management of TB is still challenging. Mycobacterium tuberculosis (Mtb) is the etiological agent of TB, and TB is classified as the 13th leading cause of death globally [WHO 2021]. 558,000 people were reported to develop multi-drug resistant TB globally [WHO 2020]. Our research focuses on targeting Methionine Aminopeptidase (MetAP), an essential protein for the viability of Mtb. MetAP is a metalloprotease that catalyzes the removal of N-terminal methionine (NME) during translation of protein [Giglione et al., 2003]. This essential role of MetAPs makes this enzyme an auspicious target for …

Discovery Of Ojt010 As A Novel Inhibitor Of Severe Acute Respiratory Syndrome Coronavirus 2, Manvir Kaur

Dissertations (2016-Present)

The current pandemic of coronavirus disease (COVID-19) caused by the highly infectious pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represents a global public health challenge. The emergence of deadly SARS-CoV-2 variants with mutations on the viral genes has made it more imperative to discover therapeutics that target the host receptors for COVID-19 treatment. Therefore, our research has targeted the critical host entry receptors: Angiotensin-converting enzyme-2 (ACE2) for SARS-CoV-2 entry into the human cells. SARS-CoV-2 is an enveloped RNA beta coronavirus that infects human cells via interaction with the ACE2 receptor, followed by viral replication and virus dissemination. Spike protein …

Design And Synthesis Of Curcumin Analogs For Anticancer Activity And Discovery Of Novel Hit Molecules Targeting Cxcr4., Maryam Sadat Hosseini Zare

Dissertations (2016-Present)

Curcumin as a natural compound is made of various components including protein, carbohydrate, and curcuminoid. Curcuminoid is made of curcumin, desmethoxycurcumin and bis desmethoxycurcumin. Curcumin is used for the treatment of cancer and inflammatory disorders, but it has some therapeutic problems like poor bioavailability, poor efficacy, and chemical instability. To overcome these problems, the objective of this study is (1) synthesis of pyrazole curcumin analogs, (2) synthesis of triazole curcumin analogs, and (3) in-vitro study of the anticancer activity of these curcumin analogs on head & neck, breast, pancreatic and glioblastoma cancer cells. During this part of my Ph.D. project, …

Review Of The Latest Trends In Transplantation Immunology And Its Role In Mortality Reduction, Vivian Adedoye

Honor’s College Freeman Research Journal

Transplantation immunology deals with the process of moving cells, tissues, or organs, from one site to another, either within the same person or between a donor and a recipient. If an organ system fails, or becomes damaged because of disease or injury, it can be replaced with a healthy organ or tissue from a donor. The process of transplantation has become increasingly popular due to its life saving benefit. In 2015 /2016 4601 patients' lives were saved or improved by an organ transplant in the United Kingdom alone. Kidney transplants are the most common organ transplant followed by liver and …

Inhibition Of Serine, Glycine, One-Carbon Metabolism Reduces Proinflammatory Response, Ashlynn Mccall

Honor’s College Freeman Research Journal

Acute lung injury affects around 200,000 critically ill patients annually, with a mortality rate near 33%. With a lack of targeted therapies, it is vital to discover and understand the fundamental cellular processes that drive macrophage inflammation. In the field of macrophage immunometabolism, it is accepted that macrophages upregulating glycolysis indicates a role in proinflammatory processes, however, there is a lack of knowledge surrounding the intermediate pathways in glycolysis. This study examined the effects of serine, glycine, one-carbon metabolism inhibition on LPS-induced inflammation in bone marrow-derived macrophages. We show that the enzymatic expression of PHGDH and PSATl is unaffected when …

Tsu Faculty Research Database-Jan 2017, David Owerbach

Office of Research Institutional Research and Scholarship

Research interests and selected publications from 230 Texas Southern University faculty have been updated in Jan 2017. Faculty from Public Affairs, the College of Science, Engineering and Technology, the College of Pharmacy and Health Sciences, the College of Education, the College of Business, the College of Liberal Arts and Behavioral Sciences, the Law School and the School of Communications are included.

2016 Research Week, Linda Gardiner, David Owerbach

Office of Research Institutional Research and Scholarship

RESEARCH WEEK 2016 TABLE OF CONTENTS

ADMINISTRATION RESEARCH COMMITTEES ACTIVITY SCHEDULE

LETTERS OF ENDORSEMENT

GENERAL SESSION

FACULTY, STAFF, AND STUDENT POSTER PRESENTATIONS

FACULTY AND STUDENT ORAL PRESENTATIONS

Missed Opportunities: Public Health Disaster Management In Canada, Lisa Gorman, Christopher Stoney

Journal of Public Management & Social Policy

Three recent Canadian public health crises present an illustration of both the opportunities for reform and the challenges that may impede progress and public health renewal in federalist nations. While the three crises examined exposed serious flaws in emergency preparedness and fuelled demands for vital public health reform, evidence indicates that fundamental challenges have not been addressed and may have even heightened over the last decade given a move to “open federalism” and the significant fiscal impacts of ongoing austerity measures. With future pandemics inevitable, we identify the missed opportunities to optimize Canada’s emergency response capacity and procedures and examine …

Early Childhood Development And The Social Determinants Of Health Inequities: A Review Of The Evidence, Tim Moore, Myfanwy Mcdonal, Harriet Mchugh-Dillon

Mickey Leland Center Information Portal

This report focuses on early childhood development and the social determinants of health inequities. It is one of eight reviews of evidence commissioned by VicHealth to support the use of a planning tool for health promotion policy and practice in Victoria, known as Fair Foundations.

What Matters Most For Children: Influencing Inequality At The Start Of Life, Eboni C. Howard

Mickey Leland Center Information Portal

This paper provides an overview of the science of early childhood and summarizes the disparities and the opportunity gaps stemming from inequalities. It also describes categories of programs, services and policies for children birth to age 3 that might affect the extent of inequality and provide supportive early life experiences.

Research Week 2015, Linda Gardiner, David Owerbach

Office of Research Institutional Research and Scholarship

No abstract provided.

Faculty Research Interest Database, David Owerbach

Office of Research Institutional Research and Scholarship

No abstract provided.

Tsu Faculty Publication Database, David Owerbach

Office of Research Institutional Research and Scholarship

No abstract provided.

2014 Tsu Undergraduate Research Program, David Owerbach

Office of Research Institutional Research and Scholarship

No abstract provided.

Research Week 2014, Linda Gardiner

Office of Research Institutional Research and Scholarship

No abstract provided.

2013 Tsu Undergraduate Research Program, David Owerbach

Office of Research Institutional Research and Scholarship

No abstract provided.

Research Week 2013, Linda Gardiner

Office of Research Institutional Research and Scholarship

No abstract provided.

Behavioral Changes For African Americans To Improve Health, Embrace Culture, And Minimize Disparities, Dashiel J. Geyen Ed.D., M.P.H.

The Bridge: Interdisciplinary Perspectives on Legal & Social Policy

In spite of significant advances in the prevention, diagnoses, and treatment of most chronic diseases, there is evidence that racial and ethnic people of color tend to receive lower quality of care and less preventive interventions than the majority members of a community. While our health system should improve its efforts at addressing and reducing disproportionality in health care, African Americans can make behavioral changes through diet and exercise that will reduce their susceptibility to chronic illnesses. This article first reviews the prevalence, disparities, and characteristics of chronic diseases impacting the African American population. Second, it discusses culturally connected practices …

2012 Tsu Undergraduate Research Program, David Owerbach

Office of Research Institutional Research and Scholarship

No abstract provided.

Research Week 2012, Linda Gardiner

Office of Research Institutional Research and Scholarship

No abstract provided.

2011 Report Of The Director Of Public Health - Social Inequalities In Health In Montreal. Progess To Date, Dr. Margaret Chan, World Health Organization

Mickey Leland Center Information Portal

In 1998, the Direction de santé publique de Montréal’s first annual report noted a 10-year difference between the average life expectancy of men living in disadvantaged neighbourhoods and of those in wealthy areas. Over a decade has gone by since this first portrait of Montrealers’ state of health was published and it is now time to measure the progress we have made. Therefore, the Director’s 2011 report is focused on social inequalities in health.

A Healthy Home For Everyone: The Guide For Families And Individuals, Center For Disease Control And Prevention, Atlanta Ga

Mickey Leland Center Information Portal

The purpose of this booklet is to provide information about the connection between housing and health. You will find action steps for making your home healthy, definitions for words used in the booklet, and a resource section to find more information about a making your home a healthy home.

Reducing Disparities Beginning In Early Childhood: Short Takes No. 4, Kay Johnson, Suzanne Theberge, Copyright © 2007 By The National Center For Children In Poverty; Columbia University Mailman School Of Public Health Ny

Mickey Leland Center Information Portal

Research shows that many disparities in health and well-being are rooted in early childhood. These disparities reflect gaps in access to services, unequal treatment, adverse congenital health conditions, and exposures in the early years linked to elevated community and family risks.1 Early health risks and conditions can have long-range implications for physical, emotional, and intellectual development as well as health. Their contribution to disparities in health status, disabilities, and educational achievement is well documented.2 But many risks can be addressed in the early years, starting with quality prenatal care and interventions in the earliest stages of life. Thus, literally, reducing …