Medicine and Health Sciences Commons^™

Primate Numerical Competence: Contributions Toward Understanding Nonhuman Cognition, Sarah T. Boysen, Karen I. Hallberg

Sentience Collection

Nonhuman primates represent the most significant extant species for comparative studies of cognition, including such complex phenomena as numerical competence, among others. Studies of numerical skills in monkeys and apes have a long, though somewhat sparse history, although questions for current empirical studies remain of great interest to several fields, including comparative, developmental, and cognitive psychology; anthropology; ethology; and philosophy, to name a few. In addition to demonstrated similarities in complex information processing, empirical studies of a variety of potential cognitive limitations or constraints have provided insights into similarities and differences across the primate order, and continue to offer theoretical …

Santa Clara Magazine, Volume 42 Number 1, Summer 2000, Santa Clara University

Santa Clara Magazine

8 - ATTACK OF THE KILLER TOMATOES? By Miriam Schulman. Beyond the hype of the headlines, there are no simple answers to the ethical questions raised by genetically modified food.

14 - BRAVE NEW WORLD By Tamara Straus. Now the lawyers want inside your head as they struggle to answer, "Who owns an idea?" Just the mere question is changing the face of legal education.

18 - THE GREAT GRADE GIVEAWAY By Jeff Zorn. Today's grades don't mean jack. So says one Santa Clara professor in this memoir and commentary on the evils of modern day grade inflation.

22 - …

Role Of Lipolysis And Lipogenesis In The Development Of Diet-Induced Obesity, Michael John Davies

Theses and Dissertations in Biomedical Sciences

Obesity is an increasingly common public health problem with approximately one-half of the American adult population overweight and one-quarter considered obese. This alarming trend has led researchers to determine potential causative factors of excess weight gain in humans. However, it is difficult to discern whether perturbations that result in obesity are the cause or simply the result of the obese state. Diet-induced obesity is one of the animal models that allow researchers to address temporal issues. Our laboratory utilizes a diet-induced obesity model in which Sprague-Dawley rats are placed on a purified moderately high fat diet and ultimately diverge into …

An Ultrastructural Survey Of The Nuchal Glands Of Rhabdophis Tigrinus (Serpentes: Colubridae), Kathleen A. Roberts

Biological Sciences Theses & Dissertations

Rhabdophis tigrinus, an Asian natricine snake, possesses a series of integumentary glands located in the nuchal skin. Previous studies indicated that the nuchal glands are of mesodermal origin, contain cardiac steroids analogous to bufotoxins found in the parotoid glands of toads, which are included in the snake's diet. The nuchal glands are defensive in function. Preliminary histological studies revealed differences in quality of the gland tissue compared to previous studies, and difference in fixation techniques were suspected. Seven specimens of R. tigrinus were fixed by perfusion using a conservative fixation process standard for electron microscopy. The nuchal gland series …

Validation Of Passive Air Sampling Monitors Onboard United States Navy Submarines, Larry A. Mcfarland

Community & Environmental Health Theses & Dissertations

An operating submarine creates a unique air quality mixture of compounds that result from a combination of human metabolism, construction materials, materials brought onboard and compounds created through the interaction of ship systems. A comprehensive study of submarine atmospheres is ongoing during deployments of U.S. Navy nuclear submarines. As part of the overall effort, a paired air sampling comparison field validation was conducted to compare the air sampling effectiveness of passive diffusive monitors compared to more traditional active air sampling methods when sampling for acrolein, formaldehyde and ozone in the enclosed submarine atmosphere. Acrolein monitors containing 2-hydroxymethylpiperidine (HMP) impregnated glass …

Increased Levels Of Multiple Forms Of Dihydrofolate Reductase In Peripheral Blood Leucocytes Of Cancer Patients Receiving Haematopoietic Colony-Stimulating Factors: Interim Analysis, M P. Iqbal, I A. Burney, F Sultana, N Mehboobali, T Siddiqui

Department of Biological & Biomedical Sciences

The precise mechanism whereby granulocytes proliferate when haematopoietic colony stimulating factors (CSFs) are used in neutropenic cancer patients is poorly understood. The purpose of this study was to investigate whether these cytokines bring about leucocyte proliferation by increasing the levels of multiple forms of dihydrofolate reductase (DHFR). Blood samples were collected from 36 cancer patients (25 males and 11 females) with chemotherapy-induced neutropenia. One sample of blood from each patient was obtained before therapy either with CSF, such as granulocyte colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) or with placebo, and another one at the time of …

Method And Apparatus For Controlling Acoustic Signal Bandwidth In An Ultrasonic Diagnostic Imaging System, Jeffrey R. Resnick, Gregory R. Bashford

Biomedical Imaging and Biosignal Analysis Laboratory

An ultrasonic imaging system includes a receive beamformer that generates analog receive signals and a scan converter. A receive signal processing path interconnects the receive beamformer and the scan converter, and this processing path included both an A/D converter characterized by a selectable sampling rate and at least one filter characterized by at least one filter parameter. The filter parameter is selected as a function of the sampling rate to provide enhanced image quality.

Pulse And Canola Frost Identification:The Back Pocket Guide, Craig White

Bulletins 4000 -

This field guide will help you identify the common symptoms of frost damage in pulse and canola crops. It also contains pictures of other plant symptoms often confused with frost damage in these crops.

Frost damage reduces crop yield and grain quality. Early identification of symptoms allows timely crop salvage decisions to be made.

Inspect pulse and canola crops between bud formation and during pod growth if right air temperature (recorded 1.2 m above ground) falls below 2 degrees celsius and there was a frost.

Check low lying, light coloured soil types and known frost prone areas first. Then check …

Association Of Epstein Barr Virus (Ebv) With Nasopharyngeal Carcinoma (Npc), S H. Shah, I N. Soomro, S Haroon, T Moatter

Department of Pathology and Laboratory Medicine

Aim:
To observe the frequency of nasopharyngeal carcinoma (NPC) and its association with Epstein Barr Virus (EBV) infection.
Setting:
This study included consecutive cases of nasopharyngeal carcinoma, which were diagnosed in the Department of Pathology at the Aga Khan University Hospital, Karachi in the period of two years (1996-97).
Methods:
These tumors were initially evaluated on H&E stained sections. The tumors showing evidence of keratinization were excluded from the study. The Epstein Barr Virus was detected with the help of Polymerase chain reaction in formalin fixed, paraffin embedded tissue sections.
Results:
During the study period, seventeen cases of nasopharyngeal carcinoma …

Expression And Requirement Of Epithelial Fatty Acid- Binding Protein In Neuronal Axon Growth, Gregory William Allen

Loma Linda University Electronic Theses, Dissertations & Projects

Epithelial fatty acid-binding protein (E-FABP) is expressed in the dorsal root ganglia following sciatic nerve injury and in migrating and differentiating neurons during neuronal development. It was hypothesized that E-FABP expression is required for the robust outgrowth of axons from developing and regenerating neurons. To test this hypothesis, E-FABP expression in both PC12 cells and primary retinal neurons was examined. In PC12 cells, NGF induces E-FABP mRNA and protein during the period of neurite outgrowth, and E-FABP localizes to the perinuclear cytoplasm, nucleus, and growth cone. Furthermore, E-FABP-deficient cell lines exposed to NGF were less differentiated and had shorter neurites …

Post-Treatment Evaluation Of Isometric Function Of The Elevator Muscles, Margaret Barbara Kowalczyk

Loma Linda University Electronic Theses, Dissertations & Projects

This study mainly examined neuromuscular function, occlusal index, and centric relation-centric occlusion (CR-CO) discrepancy of 23 orthodontically treated patients. Phase I, craniofacial anomalous, and orthognathnic surgery cases were excluded from the study. Record taking was done in 2 sessions: (1) at the time of deband and (2) 3-4 months later. Records taken at each session included facial and intraoral photographs, impressions, CR wax bites, a facebow, and surface EMG (sEMG) recordings.

For the sEMG recordings, electrodes were placed on the upper hyoid, masseter, and anterior temporalis muscles. Subjects were asked to perform numerous tests; these included baseline, clenching to test …

Identification And Characterization Of Control Elements Within The Murine Cd4 Gene, Zhong Deng

Loma Linda University Electronic Theses, Dissertations & Projects

The control of CD4 gene expression is essential for T lymphocyte development. Since the molecular mechanism for the control of CD4 gene expression during T cell development had not been elucidated, a study of the factors that control CD4 gene expression may lead to further. Toward these goals, we have made a series of recombinant DNA constructs to define the cis-acting transcriptional control elements in the murine CD4 locus that control CD4 gene expression during T cell development. In this study, we have identified multiple cis-acting control elements, which are critical for regulating the expression of the murine …

2nd Annual Pacific Research Day Abstracts, University Of The Pacific

Excellence Day

No abstract provided.

Efflux Of Osmolyte Amino Acids During Isovolumic Regulation In Hippocampal Slices, Rodrigo Franco, Octavio Quesada, Herminia Pasantes-Morales

School of Veterinary and Biomedical Sciences: Faculty Publications

The efflux of potassium (K⁺) and amino acids from hippocampal slices was measured after sudden exposure to 10% (270 mOsm), 25% (225 mOsm) or 50% (150 mOsm) hyposmotic solutions or after gradual decrease (22.5 mOsm/min) in external osmolarity. In slices suddenly exposed to 50% hyposmotic solutions, swelling was followed by partial (74%) cell volume recovery, suggesting regulatory volume decrease (RVD). With gradual hyposmotic changes, no increase in cell water content was observed even when the solution at the end of the experiment was 50% hyposmotic, showing the occurrence of isovolumic regulation (IVR). The gradual decrease in osmolarity elicited …

Unusual Polymorphisms In Human Immunodeficiency Virus Type 1 Associated With Nonprogressive Infection, Louis Alexander, Emma Weiskopf, Thomas C. Greenough, Nathan C. Gaddis, Marcy C. Auerbach, Michael H. Malim, Stephen J. O'Brien, Bruce D. Walker, John L. Sullivan, Ronald C. Desrosiers

Biology Faculty Articles

Factors accounting for long-term nonprogression may include infection with an attenuated strain of human immunodeficiency virus type 1 (HIV-1), genetic polymorphisms in the host, and virus-specific immune responses. In this study, we examined eight individuals with nonprogressing or slowly progressing HIV-1 infection, none of whom were homozygous for host-specific polymorphisms (CCR5-Δ32, CCR2-64I, and SDF-1-3^'A) which have been associated with slower disease progression. HIV-1 was recovered from seven of the eight, and recovered virus was used for sequencing the full-length HIV-1 genome; full-length HIV-1 genome sequences from the eighth were determined following amplification of viral …

Teaching The Ethics Of Biology, David Harris Phd, Carol K. Johansen

Faculty Publications

Discusses the basic principles of ethics and ethical decision making as applied to biology. Ethical issues associated with biology; Theoretical basis of ethical decision-making; Models of ethical decision-making; Social implications of scientific experimentation and discovery.

Electrically Mediated Plasmid Dna Delivery To Hepatocellular Carcinomas In Vivo, L. Heller, M. J. Jaroszeski, D. Coppola, C. Pottinger, R. Gilbert, Richard Heller

Bioelectrics Publications

Gene therapy by direct delivery of plasmid DNA has several advantages over viral gene transfer, but plasmid delivery is less efficient. In vivo electroporation has been used to enhance delivery of chemotherapeutic agents to tumors in both animal and human studies. Recently, this delivery technique has been extended to large molecules such as plasmid DNA. Here, the successful delivery of plasmids encoding reporter genes to rat hepatocellular carcinomas by in vivo electroporation is demonstrated.

Method And Apparatus For Three-Dimensional Ultrasound Imaging Of Biopsy Needle, Syed Omar Ishrak, Mir Said Seyed-Bolorforosh, William Thomas Hatfield, Todd Michael Tillman, Brian Peter Geiser, Gregory R. Bashford, Michael Joseph Washburn

Biomedical Imaging and Biosignal Analysis Laboratory

A method and an apparatus for three-dimensional ultrasound imaging of a needle-like instrument, such as a biopsy needle, inserted in a human body. The instrument is visualized by transmitting ultrasound beams toward the instrument and then detecting the echo signals using a linear array of transducer elements. The problem of ultrasound being reflected from a biopsy needle in a direction away from the transducer array is solved by steering the transmitted ultrasound beams t increase the angle at which the beams impinge upon the biopsy needle. Ideally the ultrasound beams are perpendicular to the needle. This increases the system's sensitivity …

Molecular Evolution Of Insecticidal Spore-Forming Bacteria, John Pool

Honors Theses

Molecular methods are increasingly being used to determine the phylogeny of microorganisms. This research was intended to determine phylogenetic relationships for bacteria of the species Bacillus thuringiensis and other members of the Bacillus cereus group. Each strain was analyzed by its sasp-B gene sequence to determine its species classification and relation to other strains studied. Results of this study indicated that according to the sasp-B gene tree, the species Bacillus thuringiensis is a paraphyletic with respect to both Bacillus cereus and Bacillus anthracis. Some unexpected results and implications for species designations are also discussed.

Santa Clara Magazine, Volume 41 Number 4, Spring 2000, Santa Clara University

Santa Clara Magazine

10 - THE IMPORTANCE OF REMEMBERING By Tamara Straus. On the I0-year anniversary, Santa Clara looks back at the Jesuit murders in El Salvador and finds a lasting legacy for the campus community.

16 - 64 MILLIONAIRES A DAY By Susan Vogel. Are they savvy or stingy? The wealthy in Silicon Valley are taking a new approach to philanthropy, but are they giving their fair share?

20 - EDUCATING FOR LIFE AND LEADERSHIP Santa Clara University is just months away from launching its year-long 150th anniversary celebration. Here's a preview of the five major sesquicentennial events.

Research Ethics: An Introduction, Tom Regan

Ethics in Science and Engineering National Clearinghouse

Research Ethics: an Introduction focuses both on how Responsible Conduct of Research (RCR) fits into the field of applied ethics and on procedures for making decisions that have a moral component. Tom Regan presents “Morally Relevant Questions: A Check List” with the central theme of balancing conflicting obligations. We expand this discussion with several classic resources by well known experts in research ethics that articulate critical topics. We present a Case Study from The Association for Practical and Professional Ethics. We consider the question of professional codes and think about the toll of making the right decision. In the Additional …

The Mentoring Of Graduate Students, Margaret King

Ethics in Science and Engineering National Clearinghouse

The Mentoring of Graduate Students presents basic issues that face both mentors and their protégés. Margaret King, the Graduate School, is our faculty guide for this module. We focus on some of the ethical values most central to the mentoring process such as justice and the idea of contracts. One of the challenges of the mentoring experience is that it involves rules and practices both tangible and intangible. Dr. King explores some of these intangibles- Right Attention, Right Balance, Right Empowerment and Right Boundaries- in the central essay and we focus on them additionally in our Central Theme section. We …

Responsible Authorship And Peer Review, James Wilson

Ethics in Science and Engineering National Clearinghouse

Responsible Authorship and Peer Review presents the basic issues facing researchers at the publication stage of research. We focus on some of the ethical values particularly relevant to publication: honesty, objectivity, trust, collegiality, and the problem of power differentials. We present Jim Wilson’s Guidelines for Authors and the Office of Research Integrity (ORI) Guidelines: ORI has also posted extensive materials on authorship and peer review issues. We present a Case Study from The Association for Practical and Professional Ethics. We consider the challenges of peer review, especially in terms of innovation in research. In the Resources section, you will find …

Animal Subjects In Research, Nell Kriesberg, Richard Fish

Ethics in Science and Engineering National Clearinghouse

Animal Subjects in Research presents an overview of research integrity as it relates to working with animal subjects. The Introduction will focus on major ideas in the current philosophic discussion, albeit in summary fashion. We link directly to an online course developed by Rick Fish covering a wide range of topics, including a discussion of ethics as well as a separate tutorial on models. We then focus on the regulations and guidelines, both at the national and local level as well as describing and linking to the training requirements at NC State. We present a Case Study from The Association …

Professional Responsibility And Codes Of Conduct, Nell Kriesberg

Ethics in Science and Engineering National Clearinghouse

Professional Responsibility and Codes of Conduct presents an overview of major issues concerning professionalism as they relate to the Responsible Conduct of Research (RCR). Joe Herkert emphasizes both the micro (between individuals) and macro (between professionals and society) ethical dimensions of professional responsibility and codes of conduct. We compare ethical codes with aspects of moral theory, expanding the discussion with some of the classical readings for this topic. We present a case study from the Association for Practical and Professional Ethics. We consider the complex issue of whistle-blowing. We close with a sampling of additional resources.

Human Subjects In Research, Matt Ronning

Ethics in Science and Engineering National Clearinghouse

Human Subjects in Research presents basic ethical issues that face researchers when doing work with human participants. Matt Ronning, Assistant Vice Chancellor for Research Administration Sponsored Programs and Regulatory Compliance, (SPARCS) is our guide for this module. In the Overview section we review chapters from two well known textbooks on Research Ethics. In the Applied Ethics section we focus on the consent form as a contract and comment upon the recurring topics of Justice and Honesty as they apply particularly to human subjects. In the Central Theme section we review institutional guidelines, both at the national and institutional level, utilizing …

Rightdoing And Misconduct In Research, Rebeca Rufty, Nell Kriesberg

Ethics in Science and Engineering National Clearinghouse

Rightdoing and Research presents the major issues concerning research integrity and misconduct; we intend this to be more of a reference handbook than the other modules in the series. Our faculty expert for this module is Becky Rufty, the Graduate School. Concepts of Rightdoing and integrity are discussed, and we expand the discussion with several key articles in the evolution of research ethics literature. Ethical concerns about ambiguity and trust are explored, as is the idea of micro and Macroethics. We focus on the resources at NC State University for promoting research integrity, as well as national guidelines. We present …

Intellectual Property - Copyright, Peggy Hoon

Ethics in Science and Engineering National Clearinghouse

The goal of this module is to present the major issues surrounding intellectual property (IP): rather than attempt to discuss all four types of IP, trademarks, trade secrets, patents and copyright, we will focus on copyright. Our Faculty Expert for this module is Peggy Hoon, Director of the Scholarly Communications Center, NC State University. The Overview section presents two chapters from two well known textbooks on research ethics. In the Applied Ethics portion we discuss the idea of the labor contract and the idea of the Intellectual Commons to clarify some of the more complex issues. In the Central Theme …

Responsible Use Of Statistical Methods, Larry Nelson, Charles Proctor, Cavell Brownie

Ethics in Science and Engineering National Clearinghouse

Responsible Use of Statistical Methods focuses on good statistical practices. In the Introduction we distinguish between two types of activities; one, those involving the study design and protocol (a priori) and two, those actions taken with the results (post hoc.) We note that right practice is right ethics, the distinction between a mistake and misconduct and emphasize the importance of how the central hypothesis is stated. The Central Essay, Identification of Outliers in a Set of Precision Agriculture Experimental Data by Larry A. Nelson, Charles H. Proctor and Cavell Brownie, is a good paper to study. The Applied Ethics section …

Science And The Media: Ethics Issues, Joann Burkholder

Ethics in Science and Engineering National Clearinghouse

This module addresses the complex interface of research and the media; this interface necessarily involves issues of public policy, however, for the purposes of this module we will focus on media issues and touch on public policy in the Thinking Outside the Box section. For simplicity, when we refer to “media” we are speaking of journalists covering the science beat. In the Introduction we talk about the special collaboration between the media and the researcher and the challenges both face in communicating science to the public at large. We note the ethical component inherent in all communication and include quotations …