Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- ALS (1)
- Amyotrophic lateral sclerosis (1)
- Cancer (1)
- Chickenpox (1)
- Environmental factors (1)
-
- Epidermal Growth Factor Receptor Mutations (1)
- Face blindness (1)
- Gastroesophageal reflux disease (1)
- HPV (1)
- Human papillomavirus (1)
- Hutchinson-Gilford Progeria Syndrome (1)
- Immunotherapy (1)
- Infants (1)
- Inhibition (1)
- Ischemia (1)
- Lung cancer (1)
- Mycobacterial enoyl reductase InhA (1)
- Myopia (1)
- Nearsightedness (1)
- Neural plasticity (1)
- PARP inhibition (1)
- Pancreatic cancer (1)
- Prosopagnosia (1)
- Shingles (1)
- Stem cells (1)
- Therapeutics (1)
- Tuberculosis (1)
- Vaccinations (1)
- Varicella zoster virus (1)
Articles 1 - 12 of 12
Full-Text Articles in Medicine and Health Sciences
Prosopagnosia, Leah Fleischman
Prosopagnosia, Leah Fleischman
The Science Journal of the Lander College of Arts and Sciences
Prosopagnosia is a cognitive disorder that affects one’s ability to recognize faces. Prosopagnosia can be caused by a congenital defect, or it can be acquired as a result of brain damage. Much research has been devoted to discovering the specific causes and effects of Prosopagnosia. Many case studies have been performed in order to determine the specific effects that each case of Prosopagnosia causes for various individuals suffering from the disease. This article discusses the various aspects of Prosopagnosia; specifically focusing on the behavioral, anatomical, and neurological implications
Parp Inhibition: A Method Of Treating And Preventing Certain Cancers, Chana Tropper
Parp Inhibition: A Method Of Treating And Preventing Certain Cancers, Chana Tropper
The Science Journal of the Lander College of Arts and Sciences
Breast cancer is one of the largest causes of cancer related deaths in women. Less than 5% of breast cancer cases are genetically inherited and most often develop after menopause. The BRCA gene mutation is a genetic inheritance which increases ones chances of developing breast cancer at a young age tenfold. Recent research has proposed a method of treatment in genetically inherited breast cancers by taking advantage of the impaired DNA repair pathway caused by the BRCA mutation. The combination of a BRCA mutation, which leads to deficient double strand DNA repair, and PARP inhibition, which leads to deficient single …
Immunotherapy As A Treatment Option For Patients With Pancreatic Cancer, Yehuda Lehrfield
Immunotherapy As A Treatment Option For Patients With Pancreatic Cancer, Yehuda Lehrfield
The Science Journal of the Lander College of Arts and Sciences
Pancreatic cancer is one of the worst forms of cancer that can develop in an individual. Traditionally, chemotherapy is administered but it has very limited success. Using the immune system to treat the cancer is very enticing and many studies have been conducted to attempt to harness the body’s own mechanisms to defeat the cancer. It seems that in order to properly treat the tumor a two pronged approach must be used. First, the immune system must be stimulated to react to the tumor and attack it. A possible cytokine that can be utilized is interferon alpha, which could result …
The Efficacy And Safety Of The Human Papillomavirus Vaccine, Gail Tessler
The Efficacy And Safety Of The Human Papillomavirus Vaccine, Gail Tessler
The Science Journal of the Lander College of Arts and Sciences
The HPV virus is said to be the cause of many infections, warts, and cancers. In addition to the fact that the treatment for HPV is not always successful, not every individual knows that s/he is infected and is very likely to infect his or her partner, too. This is one factor that explains why 14 million people each year in America alone contract HPV and makes cervical cancer so threatening to many people worldwide. In light of this and the known dangers of cervical, anal, vaginal and penile cancers, the HPV vaccine was created to prevent an infection of …
Pediatric Gastroesophageal Reflux Disease, Adina Mezrahi
Pediatric Gastroesophageal Reflux Disease, Adina Mezrahi
The Science Journal of the Lander College of Arts and Sciences
This objective of this review is to present the known data in regards to Gastroesophageal Reflux Disease (GERD) in infants. Articles with relevant definitions, diagnosis and treatment options were evaluated. It is evident that much controversy exists in the diagnosis and treatment of this disease, and there is the question as whether this disease can be called GERD. Current ability to attribute the symptoms infants present with the disease is still difficult to clarify, despite the fact that as many as 60% of infants show symptoms of this disease. The current testing options have proven to be insufficient in concretely …
Theories On Varicella Zoster Virus Reactivation Based On Shingles Patterns, Ralph Nussbaum
Theories On Varicella Zoster Virus Reactivation Based On Shingles Patterns, Ralph Nussbaum
The Science Journal of the Lander College of Arts and Sciences
Herpes zoster, a disease also known as shingles or as zoster, infects the sensory nerve ganglion and the peripheral nerve and its branches, resulting in pain to the affected dermatomes. Infection results from reactivation of the varicella-zoster virus, the same virus which causes varicella, or chickenpox. The varicella-zoster virus usually causes chickenpox to its host at an early age and then withdraws to the dorsal root ganglia where it enters a latency stage. The virus may reemerge at any time and infect its host with shingles. As shingles is most common in ages 50 and above, it is assumed that …
The Search For Novel Inhibitors Of The Mycobacterial Enoyl Reductase Inha, Esther Saul
The Search For Novel Inhibitors Of The Mycobacterial Enoyl Reductase Inha, Esther Saul
The Science Journal of the Lander College of Arts and Sciences
Isoniazid (INH), one of two first-line drugs used to treat tuberculosis (TB), has been shown to be a potent inhibitor of InhA, the mycobacterial enoyl reductase. However, the increasing resistance to INH makes it imperative to find alternative drugs that are as effective as the first-line drugs, yet active against INH-resistant strains. Since InhA has been validated as an excellent target of TB, there have been attempts to find novel inhibitors of InhA. Through rational drug design, a variety of high affinity InhA inhibitors were synthesized. Triclosan itself was observed to be a suboptimal inhibitor of InhA with a K …
Environmental Factors And Progressive Myopia: A Global Health Problem, Jeffrey Weissman
Environmental Factors And Progressive Myopia: A Global Health Problem, Jeffrey Weissman
The Science Journal of the Lander College of Arts and Sciences
Myopia, or nearsightedness, is a refractive error whose prevalence has increased over the past three decades, leading to a growing concern and interest among both the public and scientific communities. For years, the only explanation and basis for myopia has been genetic factors. However, the genetic model does not explain the dramatic increase in prevalence. Current research suggests that the increase is also due to environmental factors, such as fewer hours of outdoor activities, early educational pressures requiring intense close work, as well as a lack of exposure to sunlight. One study compared the prevalence and risk factors for myopia …
Stem Cells As A Cure For Amyotrophic Lateral Sclerosis, Chaya K. Hirsch
Stem Cells As A Cure For Amyotrophic Lateral Sclerosis, Chaya K. Hirsch
The Science Journal of the Lander College of Arts and Sciences
Amyotrophic Lateral Sclerosis (ALS) is a fatal motor neuron disease which affects approximately 30,000 Americans at any given time (alsa.org, 2010). The etiology of this terminal disease unfortunately remains an unsolved mystery and has therefore severely limited the ability to find a cure. The use of stem cells to regenerate neurons has been vastly studied and have produced very promising results. However, its practicality as a cure or treatment for neurodegenerative diseases, such as ALS, is greatly compromised. Three different therapies involving stem cells were examined, Embryonic Stem Cells (ESC), induced pluripotent stem cells, (iPSC) and direct reprogramming of adult …
Neural Plasticity Following Ischemia, Shira Brickman
Neural Plasticity Following Ischemia, Shira Brickman
The Science Journal of the Lander College of Arts and Sciences
Neural plasticity refers to the ability of one’s brain to change its structure and/or function in response to changes in behavior, environment, and neural processes. When a person suffers an ischemic brain injury, it often leads to hemisyndrome with motor and sensory deficits in the arm, leg, and face of one side. This article discusses the various ways that the existing network can be restructured and neuronal connections can be remodeled after the injury to enable partial or complete recovery of motor function. Spontaneous functional recovery after stroke develops through the overlapping sequence of events including a phase of axonal …
Biomarkers In Nsclc Epidermal Growth Factor Receptor Mutations, Suzanne Freidman
Biomarkers In Nsclc Epidermal Growth Factor Receptor Mutations, Suzanne Freidman
The Science Journal of the Lander College of Arts and Sciences
Lung Cancer is the most common global cause of cancer related deaths in men and women (Markus, Alain, 2013). As standard radiation and chemotherapy have proved ineffective, novel target therapies are in the midst of development. This review will analyze the success of the inhibitor drugs targeting the Epidermal Growth Factor Receptor (EGFR) mutation, commonly found amongst Lung Cancer patients. Numerous studies and reviews are utilized to determine the cause of the 10% success rate currently exhibited for these drugs. The L858R and E746-A750 point mutations and deletions respectively, were found prevalent in responsive patients as well as clinical-pathological features …
Hutchinson-Gilford Progeria Syndrome: Pathophysiology And Possible Treatments, Pearl Hersh
Hutchinson-Gilford Progeria Syndrome: Pathophysiology And Possible Treatments, Pearl Hersh
The Science Journal of the Lander College of Arts and Sciences
Named after the two scientists who independently described the condition, Hutchinson-Gilford Progeria Syndrome (HGPS) occurs due to a mutation in the LMNA gene that codes for Lamin A, a filament protein that acts to form the nuclear lamina in the cell nucleus. This mutation is a single C-to-T substitution at nucleotide 1824 of the LMNA gene. As a result of this mutation, an abnormal protein named 'progerin' is synthesized instead of Lamin A, causing the nuclear membrane to be malformed. Since protein farnesylation is needed to target progerin to the nuclear rim, farnesyltransferase inhibitor has been proposed as a form …