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Parp Inhibition: A Method Of Treating And Preventing Certain Cancers, Chana Tropper
Parp Inhibition: A Method Of Treating And Preventing Certain Cancers, Chana Tropper
The Science Journal of the Lander College of Arts and Sciences
Breast cancer is one of the largest causes of cancer related deaths in women. Less than 5% of breast cancer cases are genetically inherited and most often develop after menopause. The BRCA gene mutation is a genetic inheritance which increases ones chances of developing breast cancer at a young age tenfold. Recent research has proposed a method of treatment in genetically inherited breast cancers by taking advantage of the impaired DNA repair pathway caused by the BRCA mutation. The combination of a BRCA mutation, which leads to deficient double strand DNA repair, and PARP inhibition, which leads to deficient single …