Medicine and Health Sciences Commons^™

Conducting A 10-Minute Search For Evidence To Aid In Clinical Decision-Making, Mark Maceachern Mlis

The Journal of the Michigan Dental Association

This article is a continuation of the Journal’s series on implementing EBD process into clinical practice. The abundance of scientific literature can make it difficult to find the best evidence to answer a clinical question. This article presents strategies for conducting a 10-minute search for the best evidence, including:

• Developing a PICO question to focus the search.
• Using free search engines such as PubMed, Google Scholar, TRIP, PubMed Clinical Queries, Medline-Plus.gov, Epistemonikos, and other online resources such as published ADA Clinical Practice Guidelines.
• Using keywords with search properties, such as Boolean Operators and filters, to discover specific types of articles, …

The Studies That Shaped A Science-Based Profession, Christopher J. Smiley

The Journal of the Michigan Dental Association

Editorial on science-based public health policy and the lessons of the Grand Rapids Study.

Relationship Between Oral Health And Clinical Osteoporosis Among Hospitalized Patients With And Without Diabetes, Kenneth Izoura, Gayle Allenback, Amber Champion, Civon Gewelber, Michael Neubauer

School of Medicine Faculty Research

Objective: Diabetes mellitus (DM) is associated with poor oral health and osteoporosis (OP). The aim of this study was to assess the relationship between OP, periodontal disease (PD), and other dental and health outcomes in a cohort of hospitalized patients with and without DM. Method: Using a cross-sectional study design, we enrolled consecutive hospitalized patients. We administered a questionnaire to gather demographic information, oral health history, smoking history, and history of OP. We inspected their dentition and reviewed their charts. Data were analyzed using t-tests, chi-square tests, and logistic regression models. Result: Out of 301 patients enrolled, 275 had PD, …

A Ferrofluidic Hydrophobic Deep Eutectic Solvent For The Extraction Of Doxycycline From Urine, Blood Plasma And Milk Samples Prior To Its Determination By High-Performance Liquid Chromatography-Ultraviolet, Ebrahim Alipanahpour Dil, Mehrorang Ghaedi, Arash Asafram, Lobat Tayebi, Fatemah Mehrabi

School of Dentistry Faculty Research and Publications

The ferrofluid phase was prepared according to mixing magnetic nanoparticle and the hydrophobic deep eutectic solvent as a green microextraction solvent. This new composite was applied for vortex-assisted dispersive liquid–liquid microextraction (VA-HDES-ferrofluid-DLLME) of doxycycline (DOC) residual extraction and determined through high-performance liquid chromatography-ultraviolet (HPLC-UV). The characterization of magnetic nanoparticle was investigated by XRD, TEM and FESEM. The dependency of DOC microextraction to main variables and their interaction and find optimum points were undertaken using response surface methodology with either central composite design (CCD). Thus, the optimum pH, ionic strength, ferrofluid volume and vortex time for DOC extraction are determined to …

The Role Of Glial Cell Derived Neurotrophic Factor In Head And Neck Cancer, Hongbin Cao, Qian He, Rie Von Eyben, Joshua Bloomstein, Dhanya K. Nambiar, Vignesh Viswanathan, Sonya Aggarwal, Shirley Kwok, Rachel Liang, Amanda J. Koong, James S. Lewis Jr., Christina Kong, Nan Xiao, Quynh-Thu Le

All Dugoni School of Dentistry Faculty Articles

Glial cell-derived neurotrophic factor (GDNF) is reported to promote the survival of neurons and salivary gland regeneration after radiation damage. This study investigated the effect of GDNF on cell migration, growth, and response to radiation in preclinical models of head and neck squamous cell carcinoma (HNSCC) and correlated GDNF expression to treatment outcomes in HNSCC patients. Our ultimate goal is to determine whether systemic administration of GDNF at high dose is safe for the management of hyposalivation or xerostomia in HNSCC patients. Three HPV-positive and three HPV-negative cell lines were examined for cell migration, growth, and clonogenic survival in vitro …

Trident - Spring 2020, Dugoni School Of Dentistry

Trident

The newsletter of the Pacific Orthodontic Alumni Chapter at University of the Pacific, Arthur A. Dugoni School of Dentistry.

Ada News - 02/17/2020, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Spontaneous Condyle-Like Development After Total Resection Of Mandible Giant Osteochondroma: Case Report And A Follow-Up For Five Years, Marco Antonio De Oliveira Filho, Luis Eduardo Almeida, Andrea Doetzer, Allan Giovanini, Osvaldo Malafaia

School of Dentistry Faculty Research and Publications

Osteochondroma manifests as a benign tumor that occurs as an abnormal bony development. This tumor is commonly asymptomatic and presents an exophytic outgrowth on bone surfaces, near synovial joints, a condition that invariably induces evident facial deformities. Treatment for this type of tumor usually involves a surgical approach promoting a total or partial resection of the affected anatomical area associated to prosthetic reconstruction of the bone area extracted. We present a case report about a giant mandibular condyle osteochondroma in a 37-year-old female patient. Her treatment involved a total condylectomy without immediate condylar reconstruction, which would be performed in a …

Ada News - 02/03/2020, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Skeletal Stability Using Adjustable Versus Mini Plates Following Bilateral Sagittal Split Ramus Osteotomy (Bssro): A Randomized Clinical Trial, Moataz Bahaa, Omniya Abdelaziz, Gamal Moutamed, Ibrahim Shindy

Dentistry

Background and Objective: This study aimed at assessing the skeletal stability of adjustable miniplates in comparison to conventional miniplates following bilateral sagittal split ramus osteotomy (BSSRO)

Materials and Methods: Fourteen patients were divided into 2 equal groups. Patients in both groups underwent BSSRO and mandibular setback. In the study group, the bone segments at the osteotomy site were stabilized using the adjustable plates and four 2.0 mm monocortical screws. In the control group, bone segments at the osteotomy site were stabilized using conventional miniplates and four 2.0 mm monocortical screws. Each patient was assessed in terms SNB, mandibular plane angle …

Insight - February 2020, Dugoni School Of Dentistry

Insight

Whether you are involved in clinical research, biomedical research, the scholarship of teaching and learning, improvement of the health care system, or professional partnerships that advance the field, we aim to spotlight the work of people at the Dugoni School.

Dental Practice Success Special Issue: Marketing Principles (February 2020), American Dental Association, Publishing Division

Dental Practice Success

No abstract provided.

Role Of Dendritic Cell-Mediated Immune Response In Oral Homeostasis: A New Mechanism Of Osteonecrosis Of The Jaw, Ranya Elsayed, Zoya Kurago, Christopher W Cutler, Roger M Arce, Jennifer Gerber, Esteban Celis, Hussein Sultan, Mahmoud Elashiry, Mohamed Meghil, Christina Sun, Caroline M Auersvald, Mohamed E Awad, Rana Zeitoun, Riham Elsayed, Mohey Eldin M Elshikh, Carlos Isales, Mohammed E Elsalanty

Faculty, Staff and Student Publications

Dendritic cells are an important link between innate and adaptive immune response. The role of dendritic cells in bone homeostasis, however, is not understood. Osteoporosis medications that inhibit osteoclasts have been associated with osteonecrosis, a condition limited to the jawbone, thus called medication-related osteonecrosis of the jaw. We propose that disruption of the local immune response renders the oral microenvironment conducive to osteonecrosis. We tested whether zoledronate (Zol) treatment impaired dendritic cell (DC) functions and increased bacterial load in alveolar bone in vivo and whether DC inhibition alone predisposed the animals to osteonecrosis. We also analyzed the role of Zol …

Comparison Of Shaping Ability Of Different Single-File Systems Using Microcomputed Tomography, Shehabeldin Mohamed Saber Prof.Dr.

Dentistry

Objectives To evaluate the shaping ability of four different single-file systems using micro-computed tomography (micro-CT). Materials and Methods Eighty mesiobuccal and mesiolingual canals of permanent mandibular molars were randomly assigned to four groups according to the file used; WaveOne Gold, RECIPROC Blue, HyFlex EDM, and One Shape (n = 20). The samples were scanned using micro-CT for the preinstrumentation record; then the canals were instrumented and scanned for the postinstrumentation records. Statistical Analysis The data were then analyzed statistically using one-way analysis of variance (ANOVA) with the level of significance set at α = 0.05. Results The results of canal …

Orthograde Apical Plug In A Traumatized Tooth With Necrotic Pulp And Immature Apex Using Calcium Silicate Cement: A Case Report, Shizrah Jamal, Fahad Umer

Section of Dental-Oral Maxillofacial Surgery

This case report describes dental management of a 15- year-old boy, undergoing treatment for Thalassaemia Major and Acute Myeloid Leukaemia with bone marrow transplant and immuno-suppressants. During the course of his treatment the patient developed a swelling in anterior maxilla and therefore was referred by the primary physician for evaluation. This case report highlights the management of medically compromised patients in a tertiary care hospital in which apexification was carried out in a permanent immature tooth utilizing MTA as an immediate apical plug.

Recent Advances In Porphyrin-Based Nanocomposites For Effective Targeted Imaging And Therapy, Navid Rabiee, Mohammad Tavakkoli Yaraki, Soha Mokhtari Garakani, Shima Mokhtari Garakani, Sepideh Ahmadi, Aseman Lajevardi, Mojtaba Bagherzadeh, Mohammad Rabiee, Lobat Tayebi, Mohammadreza Tahriri, Michael R. Hamblin

School of Dentistry Faculty Research and Publications

Porphyrins are organic compounds that continue to attract much theoretical interest, and have been called the “pigments of life”. They have a wide role in photodynamic and sonodynamic therapy, along with uses in magnetic resonance, fluorescence and photoacoustic imaging. There is a vast range of porphyrins that have been isolated or designed, but few of them have real clinical applications. Due to the hydrophobic properties of porphyrins, and their tendency to aggregate by stacking of the planar molecules they are difficult to work with in aqueous media. Therefore encapsulating them in nanoparticles (NPs) or attachment to various delivery vehicles have …

Polymeric Scaffolds For Dental Pulp Tissue Engineering: A Review, Hossein E. Jazayeri, Su-Min Lee, Lauren Kuhn, Farahnaz Fahimipour, Mohammadreza Tahriri, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Objectives

The purpose of this review is to describe recent developments in pulp tissue engineering using scaffolds and/or stem cells. It is crucial to understand how this approach can revitalize damaged dentin-pulp tissue. Widespread scaffold materials, both natural and synthetic, and their fabrication methods, and stem-progenitor cells with the potential of pulp regeneration will be discussed.

Data and Sources

A review of literature was conducted through online databases, including MEDLINE by using the PubMed search engine, Scopus, and the Cochrane Library.

Study Selection

Studies were selected based on relevance, with a preference given to recent research, particularly from the past …

Conventional And Contemporary Approaches Of Splinting Traumatized Teeth: A Review Article, Shizrah Jamal, Momina Motiwala, Rabia Ghafoor

Section of Dental-Oral Maxillofacial Surgery

Trauma moves a tooth from its original position which needs to be repositioned for optimum healing and better outcomes. To stabilize the traumatically displaced teeth, splinting is specified as the gold standard. In this article we have discussed about various old and modern techniques based on the type of material to splint teeth with dentoalveolar trauma. As per recommendation of IADT, providing flexible splint is beneficial for good healing. A biologically favourable splint should not just be user friendly but also should be convenient in terms of removal. Every technique has its merits and demerits. Iatrogenic trauma to the teeth …

Periodontal Inflammation: Integrating Genes And Dysbiosis, Shaoping Zhang, Ning Yu, Roger M Arce

Faculty, Staff and Student Publications

Biofilm bacteria co-evolve and reach a symbiosis with the host on the gingival surface. The disruption of the homeostatic relationship between plaque bacteria and the host can initiate and promote periodontal disease progression. Recent advances in sequencing technologies allow researchers to profile disease-associated microbial communities and quantify microbial metabolic activities and host transcriptional responses. In addition to confirming the findings from previous studies, new putative pathogens and novel genes that have not previously been associated with periodontitis, emerge. For example, multiple studies have reported that Synergistetes bacteria are associated with periodontitis. Genes involved in epithelial barrier defense were downregulated in …

J Mich Dent Assoc February 2020

The Journal of the Michigan Dental Association

Every month,The Journal of the Michigan Dental Association brings news, information, and features about Michigan dentistry to our state's oral health community and the MDA's 6,200+ members. No publication reaches more Michigan dentists!

In this issue, the reader will find the following original content:

• A cover story on the 2020 MDA Annual Session
• A feature covering student perspectives on the Opioid Crisis
• News you need, Editorial and regular department articles on MDA Foundation activities, Dentistry and the Law, Staff Matters, Headquarters Report, and component news

This issue also includes articles reprinted with permission:

• “Muscle Deprogramming: A Source of Confusion”, …

Craniofacial Analysis May Indicate Co-Occurrence Of Skeletal Malocclusions And Associated Risks In Development Of Cleft Lip And Palate, Denise K. Liberton, Payal Verma, Konstantinia Almpani, Peter W. Fung, Rashmi Mishra, Snehlata Oberoi, Figen Ç. Şenel, James K. Mah, John Huang, Bonnie L. Padwa, Janice S. Lee

Dental Medicine Faculty Research

Non-syndromic orofacial clefts encompass a range of morphological changes affecting the oral cavity and the craniofacial skeleton, of which the genetic and epigenetic etiologic factors remain largely unknown. The objective of this study is to explore the contribution of underlying dentofacial deformities (also known as skeletal malocclusions) in the craniofacial morphology of non-syndromic cleft lip and palate patients (nsCLP). For that purpose, geometric morphometric analysis was performed using full skull cone beam computed tomography (CBCT) images of patients with nsCLP (n = 30), normocephalic controls (n = 60), as well as to sex- and ethnicity- matched patients with an equivalent …

Adea-Adee Shaping The Future Of Dental Education Iii: Engaging With Global Networking To Enable Global Oral Health, Upen S. Patel, Lior Shapira, Jennifer E. Gallagher, Joan Davis, Lily T. Garcia, Richard W. Valachovic

Dental Medicine Faculty Research

Global networking has been identified as an important method of enhancing health care education and services in the field of dentistry.1 The ability to share expertise, resources, knowledge, and experience to benefit all is highly desired among students, educators, health care professionals, and communities globally. Both our student and patient populations are dynamic societies that are becoming increasingly complex and facing growing needs and expectations, which is a constant challenge for educators and health care professionals to satisfy.2 The key question, stemming from the Global Networking (GN) workshop of the 2017 ADEE‐ADEA Shaping the Future of Dental Education II meeting, …

Adea‐Adee Shaping The Future Of Dental Education Iii: Assessment In Competency‐Based Dental Education: Ways Forward, Ingrid Tonni, Cynthia C. Gadbury-Amyot, Marjan Govaerts, Olle Ten Cate, Joan Davis, Lily T. Garcia, Richard W. Valachovic

Dental Medicine Faculty Research

Assessment in competency-based dental education continues to be a recognized area for growth and development within dental programs around the world. At the joint American Dental Education Association (ADEA) and the Association for Dental Education in Europe (ADEE) 2019 conference, Shaping the Future of Dental Education III, the workshop on assessment was designed to continue the discussion started in 2017 at the ADEA-ADEE Shaping the Future of Dental Education II.1 The focus of the 2019 conference involved examining the potential of entrustable professional activities (EPAs) and current thinking about workplace-based assessment (WBA) within competency-based education in the 21st century. Approximately …

Ada News - 01/20/2020, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Retrospective Analysis Of The Association Of Non-Carious Cervical Lesions With Bruxism, Angelica J. Bustos, Tanya Al-Talib, Neamat H. Abubakr

Dental Medicine Faculty Research

Recently, bruxism became the center of attention for the etiological research of non-carious cervical lesions (NCCLs). The present study aims to investigate the presence and types of NCCLs associated with bruxism. Retrospective keywords search of the clinical notes of all patient charts in axiUmTM was performed using the terms “bruxism”, “attrition”, “abrasion”, “erosion”, and “abfraction”. All bruxer patients 18 years and older who presented to the UNLV School of Dental Medicine (01/01/2014 to 09/30/2018) with the complete record were included. To determine the statistical analysis implications, the chi-square test was used. Commonest types of NCCL associated with bruxism were attrition …

Ada News - 01/06/2020, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Using Big Data To Promote Precision Oral Health In The Context Of A Learning Healthcare System, Joseph Finkelstein, Frederick Zhang, Seth A. Levitin, David Cappelli

Dental Medicine Faculty Research

There has been a call for evidence‐based oral healthcare guidelines, to improve precision dentistry and oral healthcare delivery. The main challenges to this goal are the current lack of up‐to‐date evidence, the limited integrative analytical data sets, and the slow translations to routine care delivery. Overcoming these issues requires knowledge discovery pipelines based on big data and health analytics, intelligent integrative informatics approaches, and learning health systems. This article examines how this can be accomplished by utilizing big data. These data can be gathered from four major streams: patients, clinical data, biological data, and normative data sets. All these must …

Comprehensive Review Of Current Endodontic Sealers, Takashi Komabayashi, David Colmenar, Nicholas Cvach, Aparna Bhat, Carolyn Primus, Yohji Imai

Dental Medicine Faculty Publications

Endodontic sealers for non-surgical root canal treatment (NSRCT) span many compositions and attributes. This comprehensive review discusses current types of endodontic sealers by their setting reaction type, composition, and properties: zinc oxide-eugenol, salicylate, fatty acid, glass ionomer, silicone, epoxy resin, tricalcium silicate, and methacrylate resin sealers. Setting time, solubility, sealing ability, antimicrobial, biocompatibility, and cytotoxicity are all aspects key to the performance of endodontic sealers. Because sealing ability is so important to successful outcomes, the relative degree of microleakage among all the relevant sealers was calculated by way of a meta-analysis of relevant literature. Compared to AH Plus, tricalcium silicate …

Utilization Of Dental Services Among Medicaid Enrolled Pregnant Women In Virginia, Shillpa Naavaal, Tegwyn Brickhouse, Jonathan W. Yu, Joann Wells

Philips Institute for Oral Health Research Publications

The study evaluated the impact of the Virginia Medicaid dental benefit on dental services utilization among pregnant women enrolled in Medicaid. Data from a total of 10,395 women who had at least one dental claim during the 2015-2017 period were included in the study. The number of dental visits and dental services utilized per person grew from an average of 2.2 visits and 7 services in 2015 to 3.1 visits and 10.5 services in 2017, respectively. In 2017, of all dental services used, 6% were for preventive services and 59% were for treatment services. Continued efforts and targeted interventions are …

Marijuana Legislation: Identifying The Impact On The Oral Healthcare Provider, Abby L. Geiser, Jessica Reid-Burrell

Dental Hygiene Student Scholarship

Objectives/Aims: Since the mid-2000s, the United States has seen a surge in legislation involving the legalization of marijuana, both recreationally and medicinally. The relaxed laws translated into an increase of marijuana consumption and thereby a potential increase in the number of patients a provider will see that are cannabis users. The purpose of this review is to illustrate how the providers begin to see pathologies related to cannabis use more frequently, and how they will need to be prepared for ways this can be addressed. Additionally, oral healthcare providers will face ethical dilemmas and legal challenges when treating patients and …