Medicine and Health Sciences Commons^™

Surgical Techniques Of Gummy Smile Correction, Jamila Belaid

International Programs

No abstract provided.

Dendritic Cell Derived Exosomes Loaded With Immunoregulatory Cargo Reprogram Local Immune Responses And Inhibit Degenerative Bone Disease In Vivo, Mahmoud Elashiry, Mohamed M Elashiry, Ranya Elsayed, Mythily Rajendran, Carol Auersvald, Rana Zeitoun, Mohammad H Rashid, Roxan Ara, Mohamed M Meghil, Yutao Liu, Ali S Arbab, Roger M Arce, Mark Hamrick, Mohammed Elsalanty, Marshall Brendan, Rafal Pacholczyk, Christopher W Cutler

Faculty, Staff and Student Publications

Chronic bone degenerative diseases represent a major threat to the health and well-being of the population, particularly those with advanced age. This study isolated exosomes (EXO), natural nano-particles, from dendritic cells, the "directors" of the immune response, to examine the immunobiology of DC EXO in mice, and their ability to reprogram immune cells responsible for experimental alveolar bone loss

Ada News - 08/03/2020, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Is There An Association Between Oral Health And Severity Of Covid-19 Complications?, Nathalie Botros, Parvati Iyer, David M. Ojcius

All Dugoni School of Dentistry Faculty Articles

Most patients with severe complications from COVID-19 have underlying conditions such as obesity, diabetes, and hypertension. In parallel, there is growing evidence for a link between periodontitis and non-oral systemic diseases. The oral cavity is also a reservoir for respiratory pathogens, and patients with periodontal disease are more likely to develop hospital-acquired pneumonia than healthy individuals. We therefore hypothesize that improving oral health could decrease the severity of COVID-19 symptoms and reduce the associated morbidity.

New Dentist News (August 2020), Ada Committee On The New Dentist

New Dentist News

New Dentist News offers timely information on scientific, social, educational, political and economic developments affecting new dentists. This collection is historical and items may not reflect current standards. For up-to-date information contact the ADA. The New Dentist News was alternately titled ADA Lifeline, 1997-June 2001.

Synthesis Of Novel Reducing Agent For Formation Of Metronidazole-Capped Silver Nanoparticle And Evaluating Antibacterial Efficiency In Gram-Positive And Gram-Negative Bacteria, Fatemeh Farjadian, Amin Reza Akbarizadeh, Lobat Tayebi

School of Dentistry Faculty Research and Publications

In this study, a new type of silver nanoparticles capped with metronidazolium based ionic liquid is synthesized. By this aim, metronidazole is altered to ionic-liquid type structure with citrate counter ion as reducing agent. The produced reducing agent was characterized using ¹HNMR and ¹³CNMR and FT-IR. The capability of metronidazolium-based reducing agent in formation and capping silver nanoparticles was examined in a chemical reaction. More specifically, synthesized silver nanoparticles were synthesized and capped with metronidazolium-citrate based ionic liquid, while the formation of particles in 48 h was monitored by UV-Vis spectroscopy. Fourier transform infrared spectroscopy showed the presence …

J Mich Dent Assoc August 2020

The Journal of the Michigan Dental Association

Every month, The Journal of the Michigan Dental Association brings news, information, and features about Michigan dentistry to our state's oral health community and the MDA's 6,200+ members. No publication reaches more Michigan dentists!

In this issue, the reader will find the following original content:

• A cover story on "Antibiotic Guidelines for Dentistry: Who, When, What, Why, and How to Prescribe”.
• A feature, “Collaboration Is the Wave of the Future: Hospital-Based General Practice Residency”.
• “Taking Advantage of Secondary and Tertiary Evidence”, a feature in the JMDA’s series on evidence-based dentistry.
• “Statistics Tutorial Part III: Interpretation of Forest Plots from Meta …

Application Of Machine Learning Technologies For Detection Of Proximal Lesions In Intraoral Digital Images: In Vitro Study., Rohit Vadlamani

Electronic Theses and Dissertations

Background: Interpretation of bitewing radiographs is influenced by factors such as acquisition parameters (e.g. exposure, type of sensor), clinical technique, visualization (e.g. monitor type and calibration) and the observer (e.g. experience and fatigue bias). We hypothesized that the use of artificial intelligence (AI) will reduce visualization and observer factor in bitewing interpretation and improve diagnostic accuracy. Objective: The purpose of the present study was to evaluate the use of AI in the form of a machine-learning algorithm to detect and quantify proximal lesions compared with human trained observers. Methods: 16,000 anonymized, digital bitewings of patients were hand searched and non-bitewing, …

Cyclic Fatigue Resistance Of Three Heat-Treated Nickel-Titanium Instruments At Simulated Body Temperature, Shehabeldin Mohamed Saber Prof.Dr.

Dentistry

Introduction: The aim of this study was to evaluate the cyclic fatigue resistance of three heat-Treated nickel-Titanium (NiTi) systems at simulated body temperature. Materials and Methods: Twelve instruments of similar apical diameter (#25) from three engine-driven NiTi instruments; WaveOne Gold (WOG), Hyflex EDM (HEDM), and M Pro system were tested for cyclic fatigue resistance at 37°C in simulated root canals with 60° angle of curvature and 5 mm curvature radius. All instruments were operated until fracture occurred. Mean and standard deviation of the time to fracture and fragment length were calculated, and statistical significance was set at 5%. The morphological …

Epithelial Responses To Porphyromonas Gingivalis In The Community Context., Zackary Ray Fitzsimonds

Electronic Theses and Dissertations

Porphyromonas gingivalis, a keystone pathogen for periodontal disease, initiates a complex molecular dialogue with gingival epithelial cells, leading ultimately to disruption of host signaling pathways. Dysbiotic host responses are also thought to contribute to the initiation and progression of oral squamous cell carcinomas. Recently, the homeostatic commensal Streptococcus gordonii has been shown to antagonize P. gingivalis-induced epithelial cell signaling events in host cells, such as proliferation and migration. The aim of this study was to characterize pathways that P. gingivalis targets to disturb host signaling, with a specific focus on pathways that S. gordonii can restore to homeostatic …

Effect Of Dentin Biomodification Delivered By Experimental Acidic And Neutral Primers On Resin Adhesion, Lívia Tosi Trevelin, Yvette Alania, Mathew Mathew, Rasika S. Phansalkar, Shao-Nong Chen, Guido F. Pauli, Ana K. Bedran-Russo

School of Dentistry Faculty Research and Publications

Objectives

Proanthocyanidins (PACs) are biocompounds mimicking native collagen cross-links. The effective and practical delivery of any biocompound is pivotal for clinical usage. The aim was to investigate the dentin biomodification and effective formation of dentin–resin biointerfaces of two highly bioactive PAC-rich extracts, Vitis vinifera (Vv) and Camellia sinensis (Cs), delivered using neutral (NP) or acidic (AP) rinse-out primer approaches.

Methods

The depth of dentin demineralization (optical profilometry), dentin biomodification (apparent modulus of elasticity, collagen auto-fluorescence) and properties of dentin–resin interfaces (microtensile bond strength - μTBS, and micro-permeability) were investigated. NP consisted of either 15% Vv or Cs applied for …

Left Ventricular Global And Regional Deformation In Arrhythmic Myxomatous Bileaflet Mitral Valve Prolapse Syndrome, Lakshmi Muthukumar, Arshad Jahangir, M. Faud Jan, Patrycja Galazka, Matt Umland, Mckenzie R. Schweitzer, Ana Cristina Perez Moreno, Maharaj Singh, Bijoy K. Khandheria, A. Jamil Tajik

School of Dentistry Faculty Research and Publications

No abstract provided.

Adoptive Treg Cell-Based Immunotherapy: Frontier Therapeutic Aspects In Rheumatoid Arthritis, Mahdi Zavvar, Sara Assadiasl, Sina Zargaran, Maryam Akhtari, Behzad Poopak, Rassoul Dinarvand, Yousef Fatahi, Lobat Tayebi, Narjes Soleimanifar, Mohammad Hossein Nicknam

School of Dentistry Faculty Research and Publications

The major current focus on treating rheumatoid arthritis is to put an end to long-term treatments and instead, specifically block widespread immunosuppression by developing antigen-specific tolerance, while also permitting an intact immune response toward other antigens to occur. There have been promising preclinical findings regarding adoptive Treg cells immunotherapy with a critically responsible function in the prevention of autoimmunity, tissue repair and regeneration, which make them an attractive candidate to develop effective therapeutic approaches to achieve this interesting concept in many human immune-mediated diseases, such as rheumatoid arthritis. Ex vivo or invivo manipulation protocols are not only utilized to correct …

Effect Of Fabrication Method On The Structure And Properties Of A Nanostructured Nickel-Free Stainless Steel, L. Heidari, A. Tangestani, M. J. Hadianfard, Daryoosh Vashaee, Lobat Tayebi

School of Dentistry Faculty Research and Publications

An ASTM F2581 nanostructured stainless steel was fabricated by two different powder metallurgy routes; Hot Powder Forging (HPF) and Binder Assisted Extrusion (BAE) methods. Their structure and mechanical properties were investigated and compared. In both fabrication methods, the alloy powder was made by using main alloying elements through mechanical alloying, along with the addition of a sintering aid. In the BAE method, a paste was prepared by mixing alloy powders with polymer followed by cold extrusion, polymer removal, and sintering. In the HPF method, the alloy powders were hot forged under high pressure. The structure and the size of the …

N Y State Dent J August-September 2020

The New York State Dental Journal

The New York State Dental Journal (NYSDJ) is produced by the New York State Dental Association (NYSDA) six times a year, in January, March, April, July, September and November. Each issue features clinical and scientific articles written by researchers and practitioners from around the globe and is subject to review by a panel of specialists convened by the Editor.

Issues include cover and feature articles alongside regular columns with regional news impacting the New York membership including editorial and perspectives columns, legal, association activities, component news, continuing education opportunities, and classifieds.

Predictors Of Dental Students’ Behavioral Intention Use Of Teledentistry: An Application Of The Unified Theory Of Acceptance And Use Of Technology (Utaut) Model, Jafar Hassan Alabdullah

Health Services Research Dissertations

Shortages of dental professionals and access barriers to dental care are challenges to improving oral health and decreasing the burden of dental diseases. There are more than 57 million individuals in the U.S. who live in dental health professional shortage areas (DHPSA). The U.S. DHPSA areas need 9,951 dental practitioners to overcome the obstacles to oral care access. Due to dental care needs for these populations, it is imperative to find a new method to reach these underserved populations. Teledentistry is an innovative technology that can be used to improve access to care and oral health outcomes. Unfortunately, there is …

Orthodontic Treatment Combined With Autotransplantation In Adults, I-Ting Chiang, Yi-Horng Chen, Rebecca Chen, Chien-Cheng Chen

Taiwanese Journal of Orthodontics

A 28-year-old female with mild skeletal Class II and dental Class I malocclusion had chief complaint of teeth crowding and poor esthetics. The patient presented with a convex facial profile, long face with a steep mandibular angle, bimaxillary dentoalveolar protrusion with 9 mm overjet, and dental crowding. She had severe caries on the maxillary right first and second molars, and the mandibular left second molar. The mandibular left first and second premolars had ill-fitting porcelain-fused-to-metal crowns. The maxillary right third molar and the mandibular left third molar were impacted. The orthodontic treatment included autotransplantation of the maxillary left first premolar …

Molar Protraction Through Downward Extension Of Maxillary Sinus In Patient With Central Diastema Caused By Small Lateral Incisors, Hsien-Fang Hung, Ming-Chu Huang, Ming-Jeaun Su

Taiwanese Journal of Orthodontics

A 32-year-old male patient presented with upper central diastema resulting from upper bilateral smallsized lateral incisors. The patient also had a deep bite of dental origin. A relatively simple mechanotherapy with pre-adjusted edgewise appliances was applied. A favorable and stable result of the ideal overbite and overjet after the correction of central diastema. Besides the above primary complaints, the prolonged retained roots of upper left first molar caused difficulty for proper space closure since the maxillary sinus wall was downward extended. The lower sinus floor may impede the orthodontic movement, but was very likely to be overlooked. The upper left …

Camouflage Orthodontic Treatment On Skeletal Class Ii Malocclusion With Idiopathic Condylar Resorption, Hsin-Yi Lo, Liang-Ru Chen, Kwong-Wa Li, Ming-Lun Hong

Taiwanese Journal of Orthodontics

Idiopathic condylar resorption (ICR), also known as idiopathic condylysis or condylar atrophy, and progressive condylar resorption (PCR), is a poorly understood progressive disease that affects the temporomandibular joint (TMJ) with multifactorial factors leading to severe mandibular retrognathism and anterior open bite. It is difficult to distinguish the exact causes for each individual. Different diagnostic methods and different treatment options can be chosen for different phases. In this report, we present a camouflage treatment with temporary anchorage devices (TADs) for a skeletal Class II open bite with ICR. The goal of improving facial profile and reconstructing of occlusion was achieved. Comprehensive …

Treatment Options For Obstructive Sleep Apnea, Shao-Chih Hsieh, Szu-Ting Chou, Yu-Chuan Tseng

Taiwanese Journal of Orthodontics

Obstructive sleep apnea (OSA) is sleep-disordered breathing caused by the collapse of the upper airway. Because anatomical abnormalities of the narrow upper airway are undoubtedly the most critical cause of OSA, the available treatment methods for OSA mostly focus on these anatomical problems. The collapse of the respiratory tract is associated with different levels of upper airway obstruction. The obstruction of the airway can be divided into three parts: the nasal cavity, retropalatal region, and retrolingual region. This article summarizes some common OSA treatment methods, their underlying theories, and their effect on the upper airway.

Effects Of Different Occlusion Setups With A Surgery-First Approach And Simulated Presurgical Orthodontics On The Mandibular Position In Skeletal Class Iii Malocclusion, Gloria Shih-Wen Fan, Yu-Chih Wang, Chiung Shing Huang, Ellen Wen-Ching Ko

Taiwanese Journal of Orthodontics

Purpose: The purposes of this study were to compare the occlusion designs implemented for the surgery-first approach (SFA) and the resultant mandibular movements by different orthodontists, as well as to investigate whether presurgical dental alignment is associated with mandibular positioning.
Methods: This prospective study included 15 patients with skeletal Class III malocclusion who underwent orthognathic surgery through the SFA. Three orthodontists designed an occlusion setup for each case, which were assigned as SFA groups. The same group of patients, who received simulated presurgical orthodontics (SPO) through a virtual setup, composed the control group. The postoperative dental relationship and resultant mandibular …

Nonsurgical Correction Of Skeletal Class Iii Malocclusion With Evident Profile Change In An Adult Patient With Functional Shift And Low Mandibular Plane Angle, Ting-Yu Kuo, Chun-Liang Kuo

Taiwanese Journal of Orthodontics

This article reports the successfully utilize the range of functional shift to treat a 16-year-old female with a chief complaint of anterior crossbite. The patient had a skeletal Class III malocclusion with a protrusive mandible, anterior crossbite, low mandibular plane angle and facial asymmetry.

To achieve optimal correction of facial profile and occlusion, orthognathic surgery would be the first treatment option. However, this patient and her family declined the surgical option for higher cost. As a consequence, we use lower anterior bite turbo to disocclude posterior teeth for the posterior teeth extrusion. Class III elastics were applied for the correction …

Non-Surgical Treatment For A Patient With Condyle Head Resorption And Unstable Occlusion, Tsung-Jui Hsieh, Tzu-Ying Wu

Taiwanese Journal of Orthodontics

This case report presents multiple TADs application technique on managing difficult dental and skeletal malocclusion. This 36-year-old female who was diagnosed as rheumatoid arthritis and had been under medication control for 6 years. In addition, she was diagnosed as condyle erosion with bilateral crepitus sound during jaw movement. The characters of occlusion including Class II malocclusion with increased overjet (6 mm), multiple posterior teeth missing and super-erupted teeth 17 and 26, and unstable occlusion. During phase I, patient was referred for occlusal splint treatment, and we followed the progression of condylar condition. At phase II, surgical intervention was suggested but …

Non-Surgical And Non-Extraction Orthodontic Treatment Of An Excess Reverse Bite With Anterior Open Bite, Jung-Chi Hsu, I-Hua Liu, Chun-Liang Kuo, Chun-Hsiu Yang, Yu-Ling Tsai, Chung-Li Wang

Taiwanese Journal of Orthodontics

This 13-year-old female had a severe Angle’s Class III malocclusion with an excessive negative overjet 7 mm, anterior open bite 2 mm, a prognathic chin and a concave lateral profile. But this patient and her parents refused orthognathic surgery. Finally, she was treated with a non-surgical and non-extraction approach. The treatment plan consisted of total distalization of mandibular dentition with bilateral temporary anchorage device (TAD) and maxillary incisor extrusion with vertical elastics. The active treatment period was 34 months. Normal overbite, overjet, and acceptable profile were achieved.

Applications Of Artificial Intelligence In Orthodontics, Hsien-Ching Hung, Yi-Chin Wang, Yu-Chih Wang

Taiwanese Journal of Orthodontics

Artificial intelligence (AI) technology is a tool for finding insights in different kind of information in medical field. The purpose of this article was giving a brief introduction to applications of AI in orthodontic treatment. The reviewed literatures were further categorized into (1) extraction or non-extraction therapy in orthodontic treatment, (2) orthognathic surgery, (3) segmentation and landmark identification, (4) growth prediction, (5) cleft related studies, and (6) TMD classification.

Surgical Methods To Accelerate Tooth Movement, Miao-Jing Chen, Shih-Chieh Chen, Jung-Hsuan Cheng, Yu-Chuan Tseng Dds, Mds, Phd

Taiwanese Journal of Orthodontics

Comprehensive orthodontic treatment usually takes 1–3 years to finish the details. The treatment duration depends on the complexity of treatment. Longer treatment times may increase the risk of root resorption, oral hygiene–related problems such as white spot lesion or dental caries, and periodontal destruction. Several methods, such as surgical-assisted procedures, drugs, and physical/mechanical stimulation methods, may accelerate tooth movement and shortened whole treatment time. This article reviews various surgical-assisted procedures and how the surgical method that can effectively shorten the treatment time. The advantages and disadvantages of various technique were also assessed.

Treatment Efficacy Of Invisalign: Literature Review Update, Meng-Huan Tsai, Stephanie Shih-Hsuan Chen, Yi-Jane Chen, Jane Chung-Chen Yao

Taiwanese Journal of Orthodontics

Purpose: Inconsistency between computer prediction and actual tooth movement in Invisalign treatment always limits clinical judgment. The objective of this review was to update the evidence on the treatment efficacy of the Invisalign appliance.
Material and Methods: Medical databases were screened for relevant peer-reviewed articles from 2000 to 2018 for the use of Invisalign as a treatment intervention. All human studies other than case reports and case series were included.
Results: A total of 25 articles (4 RCTs, 6 prospective cohort studies, 15 retrospective cohort studies) were included. Treatment outcomes have been improving over the past 17 years. Invisalign treatment …

Mir-365 (Microrna): Potnetial Biomarker In Oral Squamous Cell Carcinoma Exosomes And Extracellular Vesicles, Jeffery Coon, Karl Kingsley, Katherine M. Howard

Dental Medicine Faculty Research

Introduction: miR-365 is a non-coding microRNA that regulates transcription and has been demonstrated to promote oncogenesis and metastasis in some cancers, while suppressing these effects in others. Many microRNAs are produced and then exported extracellularly in exosomes, which are small extracellular vesicles ranging from 30 to 100 nm that are found in eukaryotic fluids and facilitate many cellular functions. Exosomes and extracellular vesicles are produced by many cell types, including oral cancer cells—although no study to date has evaluated miR-365 and oral cancer exosomes or extracellular vesicles. Based on this information, our research question was to evaluate whether oral cancers …

Rare A-Type, Spiro-Type, And Highly Oligomeric Proanthocyanidins From Pinus Massoniana, Bin Zhou, Yvette Alania, Mariana C. Reis, James Mcalpine, Ana K. Bedran-Russo, Guido F. Pauli, Shao-Nong Chen

School of Dentistry Faculty Research and Publications

An investigation of the dental bioactive proanthocyanidin (PAC) oligomer fractions led to three structurally distinct new PACs (1–3) from pine bark. Pinutwindoublin (1) is the first reported trimer with double A-type interflavanyl linkages (2α→O→5,4α→6 and 2α→O→7,4α→8). Pinuspirotetrin (2) represents the first reported PAC tetramer with a heterodimeric framework consisting of one spiro-type and one A-type dimer. Pinumassohexin (3) was elucidated as a mixed A + B-type hexamer that consists of a peanut-derived tetramer, peanut procyanidin E, and an A-type dimer (5). Compound 3 increased the modulus of elasticity of dentin …

Insight - Summer 2020, Dugoni School Of Dentistry

Insight

Whether you are involved in clinical research, biomedical research, the scholarship of teaching and learning, improvement of the health care system, or professional partnerships that advance the field, we aim to spotlight the work of people at the Dugoni School.