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Full-Text Articles in Medicine and Health Sciences

Effect Of Shear Force On Immunosuppressive Property Of Human Periodontal Ligament Cells, Ravipha Suwittayarak Jan 2021

Effect Of Shear Force On Immunosuppressive Property Of Human Periodontal Ligament Cells, Ravipha Suwittayarak

Chulalongkorn University Theses and Dissertations (Chula ETD)

The immunomodulatory property is to regulate immune cell function. IDO and TGF-β1 inhibited T cell proliferation and induced regulatory T (Treg) cells differentiation. However, this property must be activated by inflammation. Recently, mechanical forces have also activated this property. Hence, this study investigated effect of shear stress on immunosuppressive property of hPDL cells. Cells were subjected to shear stress then expression of IDO, TGF-β1, IFN-gamma and COX2 mRNA and protein was examined by qRT-PCR, ELISA, and IDO activity. Conditioned media derived shear stress were treated with CD4+ T cells. The proliferative T cell effect was determined using resazurin. The FOXP3, …


Efficacy Of Cannabidiol (Cbd) For The Treatment Of Recurrent Aphthous Ulcers, Chalapinyo Umpreecha Jan 2021

Efficacy Of Cannabidiol (Cbd) For The Treatment Of Recurrent Aphthous Ulcers, Chalapinyo Umpreecha

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objectives of this research were 1) To investigate the allergic reactions to cannabidiol (CBD) when used on human skin. 2) To assess local and systemic side effects of CBD when used on normal oral mucosa. 3) To compare the efficacy among 0.1% CBD, 0.1% triamcinolone acetonide (TA), and placebo (pure oral paste) in recurrent aphthous ulcer (RAU) treatment. This project was composed of 3 phases. Phase 1, a skin patch test was performed on 100 healthy subjects. Phase 2, CBD was applied to normal oral mucosa of 50 healthy subjects 3 times/day for 7 days. Oral examination, vital signs, …


Effects Of Local Versus Systemic Administration Of Cxcr4 Inhibitor Amd3100 On Orthodontic Tooth Movement In Rats, Narubhorn Ongprakobkul Jan 2021

Effects Of Local Versus Systemic Administration Of Cxcr4 Inhibitor Amd3100 On Orthodontic Tooth Movement In Rats, Narubhorn Ongprakobkul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Chemokines play pivotal roles in orthodontic tooth movement (OTM) through osteoclast-mediated bone resorption, but the underlying mechanism remains unclear. We aimed to elucidate the effects of serial local vs systemic administration of the chemokine receptor CXCR4 antagonist AMD3100 on OTM. The maxillary right first molar (M1) of rats was moved mesially using a 10 g of force nickel-titanium coil spring. The injections were performed every other day with phosphate-buffered saline as a control, whereas local and systemic animals were injected with AMD3100 at the buccal palatal mucosa adjacent to M1 and subcutaneously, respectively. OTM distance and alveolar bone were examined …


Differences Of Sound And Morphology In Skeletal Class Iii Patients, Natthaporn Pravitharangul Jan 2021

Differences Of Sound And Morphology In Skeletal Class Iii Patients, Natthaporn Pravitharangul

Chulalongkorn University Theses and Dissertations (Chula ETD)

[Background] This study aimed to explore differences in vowel production using acoustic analysis in skeletal Class III and Class I Japanese participants, and to investigate the correlation between vowel sounds and cephalometric variables in skeletal Class III subjects. [Materials and Methods] Japanese males with skeletal Class III (ANB<0°) and Class I skeletal relationships (0.62°


The Designs Of Miniscrew-Assisted Transpalatal Arch Affect Molar Intrusion, Ornnicha Pooktuantong Jan 2021

The Designs Of Miniscrew-Assisted Transpalatal Arch Affect Molar Intrusion, Ornnicha Pooktuantong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Abstract: An anterior open bite is one of the most difficult malocclusions in orthodontic treatment. For such malocclusion, orthodontic miniscrews insertion into both buccal and palatal alveolar regions has been indicated for molar intrusion, but it involves a risk of tooth root injury. To solve the problem, midpalatal miniscrew-attached extension arm (MMEA) is adopted. However, this method causes palatal tipping of the molar because intrusive loads were applied only from palatal side. Currently, transpalatal arch is added to avoid tipping movement, but it induces patient's discomfort. Hence, the objective of this study was to evaluate the loading conditions for maxillary …


Effects Of Intrauterine Intermittent Hypoxia On Skeletal Muscle In Offspring Rats, Wirongrong Wongkitikamjorn Jan 2021

Effects Of Intrauterine Intermittent Hypoxia On Skeletal Muscle In Offspring Rats, Wirongrong Wongkitikamjorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Gestational intermittent hypoxia (IH), a hallmark of OSA, alters the offspring's respiratory neural control and diaphragm contractile function. Thus, we aimed to investigate the effects of gestational IH on the muscle development and metabolism of geniohyoid (GH), which is innervated by the respiratory-related hypoglossal nerve and plays a role in tongue traction and suckling, in male offspring rats compared with masseter (MAS), the largest masticatory muscle. Pregnant Sprague-Dawley rats were exposed to IH (3-min periods of 4–21% O2) compared to Normoxia for 8 hours/day during gestational days 7–20. GH and MAS from 35-day-old male offspring (n = 6 /group) were …


Cellular Responses Of Stem Cells Isolated From Human Exfoliated Deciduous Teeth Towards Different Concentration Of Calcium Ion, Thanika Phlinyos Jan 2021

Cellular Responses Of Stem Cells Isolated From Human Exfoliated Deciduous Teeth Towards Different Concentration Of Calcium Ion, Thanika Phlinyos

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objectives: The purpose of this study was to investigate the effect of Ca2+ on proliferation, osteogenic differentiation, and migration of stem cells from human exfoliated teeth (SHEDs) in vitro Materials and methods: SHEDs were seeded in culture media and osteogenic induction media containing 1.8-16.2 mM of Ca2+. SHEDs proliferation was determined using MTT assay and colony forming unit assay. Osteogenic differentiation was evaluated using mineralization assay and osteogenic marker gene expression and cell migration was evaluated using wound healing assay. Values were expressed as mean + S.D. Statistical analysis of MTT assay and wound healing assay were performed using two-way …


Expression Of Vascular Endothelial Growth Factor Protein In Mrna-Transfected Human Periodontal Ligament Cells, Mana Naratippakorn Jan 2021

Expression Of Vascular Endothelial Growth Factor Protein In Mrna-Transfected Human Periodontal Ligament Cells, Mana Naratippakorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

The complete regeneration of periodontal tissues following current periodontal therapy remain challenging and unpredictable. Nucleoside-modified messenger RNA (mRNA) technology can be a promising novel platform in regenerative medicine. The aims of this study were to evaluate whether pseudouridine modified mRNA encoding vascular endothelial growth factor (VEGF) could induce VEGF production in human periodontal ligament cells (PDLCs) and this translated protein function by promoting in vivo blood vessel formation using chorioallantoic membrane (CAM) assay. Isolated PDLCs from healthy periodontal tissue were transfected with modified mRNA encoding VEGF (VEGF mRNA) complexed with a transfecting agent, Lipofectamine 2000 (L2000) and L2000 alone (control). …


The Efficacy Of Universal Ceramic Polishing Kit On The Surface Roughness Of Various Ceramic Types, Ekaluck Poosanthanasarn Jan 2021

The Efficacy Of Universal Ceramic Polishing Kit On The Surface Roughness Of Various Ceramic Types, Ekaluck Poosanthanasarn

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objective of this vitro study was to determine the effect of polishing performance of a universal ceramic polishing kit on the surface roughness of various ceramics. The ceramic specimen size 5 x 7 x 4 mm of lithium disilicate glass ceramic (IPS e.max CAD, Ivoclar Vivadent, Liechtenstein), translucent zirconia (VITA YZ XT, VITA Zahnfabrik, Germany) and zirconia-reinforced lithium silicate (Celtra Duo, Dentsply Sirona, United States) (n=8) were fixed with clear resin in PVC block, 14 mm in diameter. The specimens were ground with fine diamond bur for 15 seconds to simulate clinical gross contouring.The two-step polishing process started with …


The Effects Of The Oral Exercises On The Oral Function Of People With Dementia, Kwanrutai Somsak Jan 2021

The Effects Of The Oral Exercises On The Oral Function Of People With Dementia, Kwanrutai Somsak

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objective of this study was to examine the effects of the home-based oral exercises on the oral function in people with mild to moderate dementia. The patients with mild to moderate dementia at King Chulalongkorn Memorial Hospital, who were randomly allocated to an experimental group (n = 11), were asked to perform 3 home-based oral exercises for 3 months while those in a control group (n = 11) did not do any oral exercises. The oral function including maximum tongue pressure (MTP), oral diadochokinesis (ODK) rates of /ta/, /ka/, /pa/, swallowing function (modified water swallowing test: MWST), and oral …


Antifungal, Physical, And Mechanical Properties Of Tissue Conditioner Incorporated With Zinc Oxide Nanoparticles, Woraporn Homsiang Jan 2021

Antifungal, Physical, And Mechanical Properties Of Tissue Conditioner Incorporated With Zinc Oxide Nanoparticles, Woraporn Homsiang

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study evaluated the antifungal, physical, and mechanical properties of tissue conditioner incorporated with different amounts of zinc oxide nanoparticles (ZnOnps) at different storage times (0, 7, and 14 days). Specimens of 0, 5, 10, 15 wt% ZnOnps, or 15 wt% nystatin incorporated into tissue conditioner were fabricated. The direct contact test (n=6) was performed to evaluate the antifungal effect against C. albicans suspension. Scanning electron microscopy and energy dispersive X-ray spectroscopy (n=6) were used to observe the amount and distribution of superficial zinc element. The penetration depth (n=6) and tensile bond strength (n=8) were evaluated following ISO 13139. The …


การศึกษาผลของวัสดุบูรณะที่ปลดปล่อยแร่ธาตุต่อการคืนแร่ธาตุในรอยผุระยะเริ่มต้น ของฟันกรามน้ำนมซี่ข้างเคียงในห้องปฏิบัติการ, ดนุธิดา สาเขตร์ Jan 2021

การศึกษาผลของวัสดุบูรณะที่ปลดปล่อยแร่ธาตุต่อการคืนแร่ธาตุในรอยผุระยะเริ่มต้น ของฟันกรามน้ำนมซี่ข้างเคียงในห้องปฏิบัติการ, ดนุธิดา สาเขตร์

Chulalongkorn University Theses and Dissertations (Chula ETD)

การศึกษาในห้องปฏิบัติการนี้มีวัตถุประสงค์เพื่อเปรียบเทียบการคืนแร่ธาตุในรอยผุระยะเริ่มต้นของชิ้นฟันที่สัมผัสกับวัสดุบูรณะคลาสทูด้วยนาโนคอมโพสิตแคลเซียมฟอสเฟต (Predicta™ bioactive bulk) กับซีเมนต์กลาสส์ไอโอโนเมอร์ (Equia Forte®) และเรซินคอมโพสิตชนิดไม่ปลดปล่อยฟลูออไรด์ (Filtek™ Z350) เป็นกลุ่มควบคุม โดยใช้ชิ้นฟันน้ำนมจำนวน 60 ชิ้นจากด้านแก้มของฟันกรามน้ำนมที่ถูกถอน 60 ซี่มาสร้างรอยผุระยะเริ่มต้นที่กึ่งกลางของชิ้นฟัน นำชิ้นฟันตัวอย่างมาวัดร้อยละการสูญเสียฟลูออเรสเซนต์ (∆F) เริ่มต้นด้วยเครื่องวัดฟลูออเรสเซนต์ที่เกิดจากแสงเชิงปริมาณชนิดดิจิทัล เรียงลำดับร้อยละการสูญเสียฟลูออเรสเซนต์เริ่มต้นจากชิ้นฟันที่สูญเสียแร่ธาตุน้อยไปมาก สุ่มชิ้นฟันออกเป็น 3 กลุ่ม นำชิ้นฟันไปติดกับบล็อกอะคริลิกที่บูรณะด้านประชิดด้วยวัสดุบูรณะทั้ง 3 ชนิด แล้วเข้ากระบวนการเลียนแบบสภาวะในช่องปากเป็นเวลา 14 วัน จากนั้นวิเคราะห์ปริมาณการคืนแร่ธาตุโดยวัสดุบูรณะแต่ละชนิด ด้วยการเปรียบเทียบค่าเฉลี่ยของการเปลี่ยนแปลงร้อยละของการสูญเสียฟลูออเรสเซนต์ (∆∆F) และค่าเฉลี่ยของการเปลี่ยนแปลงปริมาตรการสูญเสียฟลูออเรสเซนต์ (∆∆Q) ผลการศึกษาพบว่าทั้งค่า ∆∆F และค่า ∆∆Q ของทุกกลุ่มมีความแตกต่างอย่างมีนัยสำคัญทางสถิติ โดยกลุ่มซีเมนต์กลาสส์ไอโอโนเมอร์ มีการคืนแร่ธาตุแก่ชิ้นฟันสูงที่สุด ส่วนกลุ่มนาโนคอมโพสิตแคลเซียมฟอสเฟตมีการสูญเสียแร่ธาตุของชิ้นฟันเล็กน้อย ซึ่งน้อยกว่ากลุ่มควบคุม คือเรซินคอมโพสิตชนิดไม่ปลดปล่อยฟลูออไรด์อย่างมีนัยสำคัญทางสถิติ สรุปได้ว่าการบูรณะด้วยวัสดุซีเมนต์กลาสไอโอโนเมอร์ สามารถคืนแร่ธาตุให้ฟันซี่ข้างเคียงได้ดีที่สุด แต่ในกรณีที่รอยผุหรือโพรงฟันคลาสทูมีขนาดใหญ่ นาโนคอมโพสิตแคลเซียมฟอสเฟตก็ถือเป็นวัสดุหนึ่งที่เป็นทางเลือกในการใช้ทดแทนเรซินคอมโพสิตชนิดไม่ปลดปล่อยฟลูออไรด์ เนื่องจากใช้งานง่าย มีความแข็งแรงและความสวยงามเทียบเท่ากับเรซินคอมโพสิต นอกจากนี้ยังช่วยยับยั้งการลุกลามของรอยผุระยะเริ่มต้นในฟันซี่ข้างเคียงได้ดีกว่าเรซินคอมโพสิตชนิดไม่ปลดปล่อยฟลูออไรด์


Influence Of Training Schedule On Learning Outcome Of Motor Skills For Dynamic Navigation System In Esthetic Zone, Wirawat Kunakornsawat Jan 2021

Influence Of Training Schedule On Learning Outcome Of Motor Skills For Dynamic Navigation System In Esthetic Zone, Wirawat Kunakornsawat

Chulalongkorn University Theses and Dissertations (Chula ETD)

Backgroud: Currently, a novel dynamic navigation system has been demonstrated to improve the accuracy of 3D implant placement, but proficiency in this system is quite difficult to achieve. Thus, the training course for using this system is required. The distributed training has been shown to be superior to massed training, it is still uncertain whether differences in distributed training rest periods will result in the best motor skill acquisition for dynamic navigation system. Purpose: The objective of this study was to determine the most effective schedule for training motor skill needed to perform implant placement using dynamic navigation system: distributed …


Finite Element Analysis Of Customized Dental Implant In Different Bone Quality, Pawhat Nimmawitt Jan 2021

Finite Element Analysis Of Customized Dental Implant In Different Bone Quality, Pawhat Nimmawitt

Chulalongkorn University Theses and Dissertations (Chula ETD)

Purpose: The purpose of this finite element analysis (FEA) study was to compare stress distribution among three different designs of a novel 3D printed root analog dental implant and a conventional screw-type implant, for different types of bone density. Materials and Methods: A mandibular right second premolar was selected from CBCT database. Four models were created: 1)Solid root analog implant 2)Solid&Porous root analog implant 3)Porous root analog implant and 4)Screw-type implant (control). Bone quality types I-IV was determined based on Lekholm and Zarb classification. Von Mises stress was measured at bone and implant. Results: FEA models were developed and von …


Retentive Force Change Of Nylon Insert In Locator R-Tx Attachment After Brushing Test, Wasita Pongwattana Jan 2021

Retentive Force Change Of Nylon Insert In Locator R-Tx Attachment After Brushing Test, Wasita Pongwattana

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aimed to evaluate the effect of brushing on the percentage change of retentive force in Locator R-Tx attachment. There were 3 types of nylon inserts; blue, pink, and clear. The nylon inserts were brushed in 2 media; water and toothpaste. Each group had 6 specimens (n=6). All specimens were soaked in deionized water at 37 ºC for 7 days, after that they were placed in the simulated brushing machine. Before and after they underwent 5,000 brushing cycles, the retention test of each specimen was measured with a universal testing machine. The retentive forces were repeatedly measured 5 times …


Comparison Of Esthetic Perception Of Maxillary Central And Lateral Incisors Between Dentists And Laypersons, Pastharee Jarusripat Jan 2021

Comparison Of Esthetic Perception Of Maxillary Central And Lateral Incisors Between Dentists And Laypersons, Pastharee Jarusripat

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objective: To compare esthetic perception between dentists and laypersons by difference of asymmetrical width and length of maxillary central and lateral incisors under 5 and 15 seconds evaluation time. Materials and Methods: Photos of women were digitally altered by Adobe Photoshop® program to create image with symmetrical and asymmetrical tooth width or length in 0.5 mm increments. Final images were randomly present on computer screen using an equal ratio to actual tooth. Thirty-six dentists and 36 laypersons were asked to rate attractiveness of those smiles on a numerical rating scale within 5 and 15 seconds of evaluation time. Mann-Whitney U …


Effects Of Small Molecules In Wnt Signaling On Human Dental Pulp Cells, Chatvadee Kornsuthisopon Jan 2021

Effects Of Small Molecules In Wnt Signaling On Human Dental Pulp Cells, Chatvadee Kornsuthisopon

Chulalongkorn University Theses and Dissertations (Chula ETD)

Osteoblast differentiation requires interaction of several cell signaling to coordinately modulate cell responses. Understanding the integration between signaling pathways provides an insight into molecular mechanism that governs stem cell differentiation. Notch, Wnt, and Interleukin15 (IL15) signaling are among the crucial pathways that control biological processes including osteogenic differentiation. Therefore, this dissertation was focused on modulating these signaling pathways in human dental pulp stem cells (hDPSCs). First, the roles of Wnt signaling in dental pulp homeostasis and dentin regeneration were reviewed. Previous evidence suggested that Wnt might be a promising target cell signaling for dentin regeneration. Thus, effect of Tideglusib, a …


Amixicile, A Novel Antimicrobial Agent, And Its Effect On The Salivary And Subgingival Microbiome In Rhesus Macaque Monkeys, Erin E. Block Jan 2021

Amixicile, A Novel Antimicrobial Agent, And Its Effect On The Salivary And Subgingival Microbiome In Rhesus Macaque Monkeys, Erin E. Block

Theses and Dissertations

Background/Purpose: Periodontitis is an inflammatory disease with a bacterial etiology in a susceptible host. A selective antibiotic with minimal systemic side effects could be a useful adjunct to traditional periodontal therapy. Amixicile is a novel antimicrobial agent that targets pyruvate: ferredoxin oxidoreductase (PFOR), an enzyme that is critical for anaerobic bacterial metabolism and has been found to have little-to-no side-effects in animal models. The aim of this study was to prospectively evaluate the effect of amixicile on clinical periodontal parameters and the composition of the oral microbiome in rhesus macaque monkeys. It was hypothesized that the amixicile would reduce growth …


Antibiotic-Loaded Dendrimer Hydrogels In Periodontal Bone Regeneration: A Feasibility Study, Nicholas G. Yesbeck Jan 2021

Antibiotic-Loaded Dendrimer Hydrogels In Periodontal Bone Regeneration: A Feasibility Study, Nicholas G. Yesbeck

Theses and Dissertations

Purpose: Prescription of a complete course of oral antibiotics following bone grafting procedures is a common clinical practice in surgical periodontics. Prophylactic administration of antibiotics reduces the risk of surgical site infection and systemic administration is preferred over local delivery because of short duration of action in the latter circumstance. The goal of this study is to demonstrate the ability of dendrimer hydrogels (DH) to prolong the release kinetics of antibiotics in-vitro. A secondary goal will be to analyze the effect of different particulate bone allografts on the release kinetics of the antibiotic.

Methods: Dendrimer hydrogels (DH) were synthesized …


Ck2 Phosphorylation Of Human Papillomavirus 16 E2 On Serine 23 Promotes Interaction With Topbp1 And Is Critical For E2 Plasmid Retention Function, Apurva Tadimari Prabhakar Jan 2021

Ck2 Phosphorylation Of Human Papillomavirus 16 E2 On Serine 23 Promotes Interaction With Topbp1 And Is Critical For E2 Plasmid Retention Function, Apurva Tadimari Prabhakar

Theses and Dissertations

Human papillomaviruses (HPVs) are the causative agents in most cervical cancers and have been implicated in a rising number of oropharyngeal cancers. HPV positive oropharyngeal cancers have increased significantly over the last two decades with no specific anti-viral therapeutic options for the treatment of HPV diseases. During its lifecycle, HPV16 encoded E2 protein interacts with host cellular factors to regulate viral transcription, replication and genome segregation/retention. Our understanding of the cellular partner proteins that E2 uses to mediate its functions remains incomplete.

Previously, an interaction between E2 and the host protein TopBP1 was identified. In earlier studies, it was also …


Il-36g Cytokine Induction In Oral Epithelial Cells Triggered By Treponema Denticola And Their Role In Chronic Periodontitis, Christopher Blake Jan 2021

Il-36g Cytokine Induction In Oral Epithelial Cells Triggered By Treponema Denticola And Their Role In Chronic Periodontitis, Christopher Blake

Theses and Dissertations

Periodontal disease is a polymicrobial disease affecting 10-15% of the population. Periodontal disease affects the quality of life by reducing mastication and potentially causing tooth loss. Periodontal disease is also linked to more severe, systemic diseases such as cardiovascular disease and rheumatoid arthritis. Development of the diseased state occurs when the plaque biofilm shifts from healthy to dysbiotic. The shift to a dysbiotic biome brings with it a shift in bacterial presence, specifically an increase in gram-negative bacteria, such as T. denticola. T. denticola is a gram-negative, anaerobic spirochete whose relationship with oral epithelial cells is poorly understood. Preliminary data …


Validation Of A Screening Tool For Pediatric Obstructive Sleep Apnea: A Pilot Study, Julia A. Giardina Jan 2021

Validation Of A Screening Tool For Pediatric Obstructive Sleep Apnea: A Pilot Study, Julia A. Giardina

Theses and Dissertations

Purpose: The purpose of this study was to evaluate the Pediatric-Modified-STOP-Bang (PM-STOP-Bang) as a screening tool to assess sleep related breathing disorders (SRBD) within a pediatric population. The specific aims of this study were: 1) compare the PM-STOP-Bang scores with those from the validated Pediatric Sleep Questionnaire (PSQ), 2) determine the ability of the PM-STOP-Bang and the PSQ screening tools to accurately detect children of high risk for SRBD from a one-night home sleep apnea test (HSAT).

Methods: Orthodontic patients were screened using the PM-STOP-Bang at VCU Graduate Clinic. Patients (n=10) who were recruited and enrolled. Five were determined to …


Radiographic Comparison Using Cbct-Pai And Volumetric Analysis Of Endodontically Treated Teeth: A Retrospective Cohort Study, Jeremy Hargrove Jan 2021

Radiographic Comparison Using Cbct-Pai And Volumetric Analysis Of Endodontically Treated Teeth: A Retrospective Cohort Study, Jeremy Hargrove

Theses and Dissertations

Purpose: To assess the changes in CBCT-PAI score as well as 3-D volume of periapical findings associated with endodontically treated roots and to see how these findings change over time.

Methods: Retrospective chart review with the following inclusion criteria: 1. At least one tooth was endodontically treated at the endodontic private practice; 2. Patient had a recall examination and the treated tooth was asymptomatic, functional and a CBCT was exposed; 3. CBCT interpretation found a periapical finding associated with the treated tooth; 4. A follow-up recall examination was completed and CBCT exposed. Cases that fulfilled the inclusion criteria had the …


Reproducibility And Accuracy Of The Virtual Occlusal Record, Anne M. Harper Jan 2021

Reproducibility And Accuracy Of The Virtual Occlusal Record, Anne M. Harper

Theses and Dissertations

Purpose: To evaluate the reproducibility and accuracy of the virtual occlusal record compared to the gold standard physical bite record

Methods: Two physical bite records of PVS and two virtual bites using an iTero Element scanner were obtained from 22 participants. Intraoral scans were exported as STL files, and virtual occlusal records were created. CBCT images were taken of physical occlusal records and converted to STL files. STL files were superimposed using Geomagic Control X™ Software. Root mean square (RMS) and percent similarity within 0.25 mm tolerance were compared at a significance level of 0.05.

Results: Average …


Virtual Reality Tool For Visualizing The Oral Microbiome, Alexus M. Harris Jan 2021

Virtual Reality Tool For Visualizing The Oral Microbiome, Alexus M. Harris

Theses and Dissertations

There are limited teaching tools for helping both students and patients understand the oral microbiome. It is important to understand the oral microbiome as it heavily influences the health of your oral cavity and the dysbiosis of disease. The oral microbiome influences other aspects of health and serves as an indicator for health. With a greater understanding of the oral microbiome, patients can make healthier lifestyle changes and dentists can better educate their patients. For that reason, the goal of this project was to create a virtual reality tool for visualizing the oral microbiome. The assets for the VR tool …


In Vitro Evaluation Of The Solubility Of Endosequence Bc Sealer In Acidic Solutions, Inderpal S. Sappal Jan 2021

In Vitro Evaluation Of The Solubility Of Endosequence Bc Sealer In Acidic Solutions, Inderpal S. Sappal

Theses and Dissertations

Purpose: In recent years, bioceramic sealers (BCS), such as EndoSequence BC Sealer, have gained popularity in endodontic practices. Previous research has found BCS difficult to remove from canals during retreatments when compared with other endodontic sealers. Acidic solutions have been found to inhibit the set of BCS and increase their solubility. The purpose of this study was to evaluate the efficacy of acidic solutions in the removal of BCS as compared with a traditional retreatment solvent.

Methods: Roots of extracted human single rooted teeth (N=15) were prepared into 17 mm sections, then instrumented with ProTaper Gold (PTG) rotary files up …


The Effect Of Local Anesthesia When Used In Dental Restorative Cases Under General Anesthesia On Control Of Intraoperative Physiologic Parameters And Post-Operative Comfort, Kathryn S. Skarda Jan 2021

The Effect Of Local Anesthesia When Used In Dental Restorative Cases Under General Anesthesia On Control Of Intraoperative Physiologic Parameters And Post-Operative Comfort, Kathryn S. Skarda

Theses and Dissertations

Purpose:

To determine the effect of local anesthesia on post-operative pain and physiologic parameters intraoperatively in patients undergoing dental care under general anesthesia.

Methods:

This study was modeled as a double-blinded randomized control trial. Patients included healthy children under the age of six scheduled for restorative dental treatment under general anesthesia. Patient behavior was evaluated pre and post-operatively using the FLACC score and post-operatively using the Parental Pain Score Measure. Intraoperatively, all participants followed a standardized general anesthesia protocol and were given either local anesthetic infiltration by the dental surgeon performing the surgery or no anesthesia was utilized. Intraoperatively physiologic …


Evaluating An Interprofessional Ergonomic Intervention For Dental Hygiene Students, Lashonna M. Knight Jan 2021

Evaluating An Interprofessional Ergonomic Intervention For Dental Hygiene Students, Lashonna M. Knight

EWU Masters Thesis Collection

Purpose: Ergonomics plays an important role in identifying and reducing biomechanical stress and preventing musculoskeletal (MSK) injuries by creating a better fit between physical requirements and work environments. This study examined the benefits of implementing an interprofessional education (IPE) module in a dental hygiene curriculum with a dental hygienist (DH) and occupational therapist (OT) teaching and assessing students’ ergonomics.

Methods: Students participated in an IPE intervention to incorporate preventive techniques into their daily routine, to model these protective strategies for use as practicing DHs throughout their careers. Prior to the module and at the end of the six-week study, students …


A Pilot Study Of Oral Health Related Quality Of Life During Gynecologic Cancer Treatment, Stephanie Kushnir Jan 2021

A Pilot Study Of Oral Health Related Quality Of Life During Gynecologic Cancer Treatment, Stephanie Kushnir

EWU Masters Thesis Collection

Purpose: The purpose of this study was to determine if oral health education increases oral health related quality of life in gynecologic oncology patients.

Methods: In this pilot study, 23 participants (18 - 70+ years) with a history of gynecologic cancer were recruited to participate in the study. Participants completed an Oral Health Impact Profile (OHIP-14) questionnaire prior to and after given education packet.

Results: At baseline, the mean pre-test OHIP-14 score was 6.7 (SD 8.4) and mean OHIP-14 post-test score was 8.8 (SD 8.4). Pearson Correlation was .90. P (T< = t) one-tail p < .008. Demonstrating statistical significance.

Conclusion: OHIP-14 scores increased after four-weeks, higher scores of …


Prerequisites In Behavioral Sciences And Business Revisited A Decade Later: Ongoing Opportunities For Dental Education, Rebecca M. Beckler, Natalie A. Nuckolls, David G. Dunning Jan 2021

Prerequisites In Behavioral Sciences And Business Revisited A Decade Later: Ongoing Opportunities For Dental Education, Rebecca M. Beckler, Natalie A. Nuckolls, David G. Dunning

Journal Articles: College of Dentistry

Introduction: Ten years ago a study reported on the lack of prerequisites in behavioral sciences and business management for entry into dental college. The primary objective of this follow-up study was to assess the current status of similar prerequisite courses in both U.S. and Canadian dental schools. Materials and Methods: Required and recommended courses in behavioral sciences and in business in each North American dental school's official online publication were analyzed in December 2019. Admissions requirements were readily available in sixty-five of the sixty-eight U.S. dental schools and in all ten schools in Canada; three U.S. schools were contacted by …