Medicine and Health Sciences Commons^™

Real-World Analysis Of Safety And Efficacy Of Car T-Cell Therapy In Lymphoma Patients With Decreased Kidney Function, Omar Mamlouk, Paolo Strati, Lei Feng, Ryan Sun, Amy Ayers, Raphael E Steiner, Ranjit Nair, Christopher Flowers, Jeremy L Ramdial, Neeraj Saini, Samer A Srour, Richard E Champlin, Partow Kebriaei, Loretta J Nastoupil, Maria A Rodriguez, Elizabeth J Shpall, Yago Nieto, Jason Westin, Sattva S Neelapu, Sreedhar Mandayam, Sairah Ahmed

Faculty, Staff and Student Publications

No abstract provided.

Multicenter Randomized Controlled Trial Of Exercise In Aortic Dissection Survivors: Rationale, Design, And Initial Hemodynamic Data, Yasmin A Toy, Kayla N House, Leslie M Boyer, Jennifer L Mcnamara, Marion A Hofmann-Bowman, Kim A Eagle, Michelle S Lim, Alan C Braverman, Siddharth K Prakash

Faculty, Staff and Student Publications

Aims: There are currently no evidence-based guidelines for exercise after thoracic aortic dissection (TAD), leading to highly variable recommendations that frequently lead patients to restrict their physical activities. This multicenter randomized controlled trial was intended to evaluate the safety and efficacy of a moderate intensity guided exercise program for TAD survivors.

Methods: Participants were eligible if they had a Type A or Type B dissection at least 90 days before enrollment and could attend two in-person study visits. The guided exercise circuit consisted of six aerobic, isotonic, or isometric exercises that participants continued at home with virtual follow-up sessions. The …

Epigallocatechin Gallate Regulates The Myeloid-Specific Transcription Factor Pu1 In Macrophages, Manjula Karpurapu, Kavita Kumari Kakarala, Sangwoon Chung, Yunjuan Nie, Amritendu Koley, Patrick Dougherty, John W Christman

Faculty, Staff and Student Publications

Our previous research demonstrated that PU.1 regulates expression of the genes involved in inflammation in macrophages. Selective knockdown of PU.1 in macrophages ameliorated LPS-induced acute lung injury (ALI) in bone marrow chimera mice. Inhibitors that block the transcriptional activity of PU.1 in macrophages have the potential to mitigate the pathophysiology of LPS-induced ALI. However, complete inactivation of PU.1 gene disrupts normal myelopoiesis. Although the green tea polyphenol Epigallocatechin gallate (EGCG) has been shown to regulate inflammatory genes in various cell types, it is not known if EGCG alters the transcriptional activity of PU.1 protein. Using Schrodinger Glide docking, we have …

Federated Multiple Imputation For Variables That Are Missing Not At Random In Distributed Electronic Health Records, Yi Lian, Xiaoqian Jiang, Qi Long

Faculty, Staff and Student Publications

Large electronic health records (EHR) have been widely implemented and are available for research activities. The magnitude of such databases often requires storage and computing infrastructure that are distributed at different sites. Restrictions on data-sharing due to privacy concerns have been another driving force behind the development of a large class of distributed and/or federated machine learning methods. While missing data problem is also present in distributed EHRs, albeit potentially more complex, distributed multiple imputation (MI) methods have not received as much attention. An important advantage of distributed MI, as well as distributed analysis, is that it allows researchers to …

Suppression Of Il-1Β Promotes Beneficial Accumulation Of Fibroblast-Like Cells In Atherosclerotic Plaques In Clonal Hematopoiesis, Trevor P Fidler, Andrew Dunbar, Eunyoung Kim, Brian Hardaway, Jessica Pauli, Chenyi Xue, Sandra Abramowicz, Tong Xiao, Kavi O'Connor, Nadja Sachs, Nan Wang, Lars Maegdefessel, Ross Levine, Muredach Reilly, Alan R Tall

Faculty, Staff and Student Publications

Clonal hematopoiesis (CH) is an independent risk factor for atherosclerotic cardiovascular disease. Murine models of CH suggest a central role of inflammasomes and IL-1β in accelerated atherosclerosis and plaque destabilization. Here we show using single-cell RNA sequencing in human carotid plaques that inflammasome components are enriched in macrophages, while the receptor for IL-1β is enriched in fibroblasts and smooth muscle cells (SMCs). To address the role of inflammatory crosstalk in features of plaque destabilization, we conducted SMC fate mapping in Ldlr-/- mice modeling Jak2VF or Tet2 CH treated with IL-1β antibodies. Unexpectedly, this treatment minimally affected SMC differentiation, …

Microbiota Restoration Therapies For Recurrent Clostridioides Difficile Infection Reach An Important New Milestone, Herbert L Dupont, Andrew W Dupont, Glenn S Tillotson

Faculty, Staff and Student Publications

Microbiota restoration therapy has become a standard treatment for recurrent Clostridioides difficile infection (rCDI). In this article, we review the studies supporting the licensure of two live biotherapeutic products (LBPs) designed to prevent rCDI and to provide clinicians with a perspective on their differences. PubMed was reviewed on 1 October 2023, for all papers published concerning the current Food and Drug Administration allowance of the use of fecal microbiota transplantation (FMT) and the studies that led to the licensure of RBX2660 (REBYOTA™), generic name, fecal microbiota, live-jslm, and SER-109 (VOWST™), generic name, fecal microbiota spores, live-brpk. OpenBiome continues to produce …

Large Language Models Struggle In Token-Level Clinical Named Entity Recognition, Qiuhao Lu, Rui Li, Andrew Wen, Jinlian Wang, Liwei Wang, Hongfang Liu

Faculty, Staff and Student Publications

Large Language Models (LLMs) have revolutionized various sectors, including healthcare where they are employed in diverse applications. Their utility is particularly significant in the context of rare diseases, where data scarcity, complexity, and specificity pose considerable challenges. In the clinical domain, Named Entity Recognition (NER) stands out as an essential task and it plays a crucial role in extracting relevant information from clinical texts. Despite the promise of LLMs, current research mostly concentrates on document-level NER, identifying entities in a more general context across entire documents, without extracting their precise location. Additionally, efforts have been directed towards adapting ChatGPTfor token-level …

Loss Of The Auxiliary Α 2Δ1 Voltage-Sensitive Calcium Channel Subunit Impairs Bone Formation And Anabolic Responses To Mechanical Loading, Madison M Kelly, Karan Sharma, Christian S Wright, Xin Yi, Perla C Reyes Fernandez, Aaron T Gegg, Taylor A Gorrell, Megan L Noonan, Ahmed Baghdady, Jacob A Sieger, Annette C Dolphin, Stuart J Warden, Padmini Deosthale, Lilian I Plotkin, Uma Sankar, Julia M Hum, Alexander G Robling, Mary C Farach-Carson, William R Thompson

Faculty, Staff and Student Publications

Voltage-sensitive calcium channels (VSCCs) influence bone structure and function, including anabolic responses to mechanical loading. While the pore-forming (α1) subunit of VSCCs allows Ca2+ influx, auxiliary subunits regulate the biophysical properties of the pore. The α2δ1 subunit influences gating kinetics of the α1 pore and enables mechanically induced signaling in osteocytes; however, the skeletal function of α2δ1 in vivo remains unknown. In this work, we examined the skeletal consequences of deleting Cacna2d1, the gene encoding α2δ1. Dual-energy X-ray absorptiometry and microcomputed tomography imaging demonstrated that deletion of α2δ1 diminished bone mineral content and density in both male and female …

Human Minor Salivary Glands: A Readily Available Source Of Salivary Stem/Progenitor Cells For Regenerative Applications, Caitlynn M L Barrows, Danielle Wu, Simon Young, Mary C Farach-Carson

Faculty, Staff and Student Publications

Resident stem/progenitor cells within the secretory salivary glands offer a potential therapeutic resource for use in the regeneration of salivary glands needed to restore saliva production in patients with chronic xerostomia, or dry mouth. Methods were developed previously to isolate human stem/progenitor cells (hS/PCs) from major salivary glands (parotid/submandibular). Abundant minor salivary glands located in readily accessible locations in the oral cavity and lip could provide an additional valuable therapeutic resource. An advantage of this cell resource is that these minor glands about the size of grape seeds can be harvested from healthy donors using minimally invasive surgical procedures. The …

Barriers And Facilitators Of Digital Health Use For Self-Management Of Hypertensive Disorders By Black Pregnant Women, Morgan A Foreman, Angela Ross, Angela P H Burgess, Sahiti Myneni, Amy Franklin

Faculty, Staff and Student Publications

Although digital health tools are increasingly common for managing health conditions, these applications are often developed without consideration of differences across user populations. A reproducible framework is needed to support tailoring applications to include cultural considerations, potentially leading to better adoption and more effective use. As a first step, this study captures a snapshot of Black women's barriers and facilitators in using digital health products for self-management of hypertensive disorders of pregnancy (HDP). One-on-one semi-structured interviews were conducted with 17 Black pregnant women with HDP. We established a unique model for cultural tailoring with these experiences using Black feminist theory …

Enhancing Patient Medication Safety At Home: A Patient-Facing Technology Architecture Integrating Redcap, Visualization Dashboards, And An Ai- Driven Chatbot, Yue Yu, Yuheng Shi, Eric Yang, Katie Gahn, Heidi Mason, Yun Jiang, Yang Gong

Faculty, Staff and Student Publications

This work demonstrates a novel architecture for a patient-facing technology (PFT) that supports patients with cancer in self-managing medication concerns and symptoms after care transitions back home. Patient-generated data are collected and stored using the framework of Research Electronic Data Capture (REDCap), which serves as a key component of the architecture. Individual patient and administrator dashboards are integrated with REDCap to visualize medication or symptom-related data and generate customized report summaries. Additionally, a Q&A chatbot, using a retrieval augmented generation (RAG) framework, is intended to integrate into the architecture to further enhance the interactivity of the PFT. The proposed architecture …

Biomedical Big Data Technologies, Applications, And Challenges For Precision Medicine: A Review, Xue Yang, Kexin Huang, Dewei Yang, Weiling Zhao, Xiaobo Zhou

Faculty, Staff and Student Publications

The explosive growth of biomedical Big Data presents both significant opportunities and challenges in the realm of knowledge discovery and translational applications within precision medicine. Efficient management, analysis, and interpretation of big data can pave the way for groundbreaking advancements in precision medicine. However, the unprecedented strides in the automated collection of large-scale molecular and clinical data have also introduced formidable challenges in terms of data analysis and interpretation, necessitating the development of novel computational approaches. Some potential challenges include the curse of dimensionality, data heterogeneity, missing data, class imbalance, and scalability issues. This overview article focuses on the recent …

Harnessing Uncertainty In Radiotherapy Auto-Segmentation Quality Assurance, Kareem A Wahid, Jaakko Sahlsten, Joel Jaskari, Michael J Dohopolski, Kimmo Kaski, Renjie He, Enrico Glerean, Benjamin H Kann, Antti Mäkitie, Clifton D Fuller, Mohamed A Naser, David Fuentes

Faculty, Staff and Student Publications

One of the key contributions of this study is the reappropriation of standard DL outputs as a quality indicator to identify cases that clinicians should review further. The authors achieve this by applying an empirically derived threshold to the softmax output of their DL network, computing the mean of the thresholded score map (termed the HiS metric), and correlating it with standard geometric quality indices. When juxtaposed with a mean entropy — a commonly used measure of model output uncertainty — HiS consistently demonstrated a stronger correlation with the geometric indices, suggesting its superior ability to stratify cases needing additional …

Microstructural Organization Of Distributed White Matter Associated With Fine Motor Control In Us Service Members With Mild Traumatic Brain Injury, Benjamin S C Wade, David F Tate, Eamonn Kennedy, Erin D Bigler, Gerald E York, Brian A Taylor, Maya Troyanskaya, Elizabeth S Hovenden, Naomi Goodrich-Hunsaker, Mary R Newsome, Emily L Dennis, Tracy Abildskov, Mary Jo Pugh, William C Walker, Kimbra Kenney, Aaron Betts, Robert Shih, Robert C Welsh, Elisabeth A Wilde

Faculty, Staff and Student Publications

Mild traumatic brain injury (mTBI) is the most common form of brain injury. While most individuals recover from mTBI, roughly 20% experience persistent symptoms, potentially including reduced fine motor control. We investigate relationships between regional white matter organization and subcortical volumes associated with performance on the Grooved Pegboard (GPB) test in a large cohort of military Service Members and Veterans (SM&Vs) with and without a history of mTBI(s). Participants were enrolled in the Long-term Impact of Military-relevant Brain Injury Consortium-Chronic Effects of Neurotrauma Consortium. SM&Vs with a history of mTBI(s) (n = 847) and without mTBI (n = …

Editorial: Methods And Applications Of Tumour Metabolic Imaging In The Preclinical And Clinical Setting, Liangjie Lin, Zhiliang Wei, Jing Wang, Nian Wang

Faculty, Staff and Student Publications

No abstract provided.

Canadian Spine Society: 24th Annual Scientific Conference, Wednesday, February 28 - Saturday, March 2, Fairmont Chateau Whistler, Whistler, Bc, Canada, Antoine Dionne, Majeed Al-Zakri, Hubert Labelle, Julie Joncas, Stefan Parent, Jean-Marc Mac-Thiong, Firoz Miyanji, Baron Lonner, Ali Eren, Patrick Cahill, Peter Newton, Jennifer A Dermott, Liisa Jaakkimainen, Teresa To, Maryse Bouchard, Andrew Howard, David E Lebel, Sarah Hardy, Armaan K Malhotra, Jennifer Dermott, Dilani Thevarajah, Karen D A Mathias, Samuel Yoon, Rajendra Sakhrekar, Dorothy J Kim, Ayesha Hadi, Andrea Doria, Aya Mitani, David Lebel, Karen Mathias, Tracey Bastrom, Amer Samdani, Marjolaine Roy-Beaudry, Marie Beauséjour, Rachelle Imbeault, Justin Dufresne, Jessica Romeo, Holly Livock, Kevin Smit, James Jarvis, Andrew Tice, Vivien K Chan, Robert Cho, Selina Poon, David L Skaggs, Geoffrey K Shumilak, Brett Rocos, Juan P Sardi, Anastasios Charalampidis, Jeff Gum, Stephen J Lewis, Peter S Tretiakov, Oluwatobi Onafowokan, Jamshaid Mir, Ankita Das, Tyler Williamson, Pooja Dave, Bailey Imbo, Jordan Lebovic, Pawel Jankowski, Peter G Passias, Stephen Lewis, Yousef Aljamaan, Lawrence G Lenke, Justin Smith, Vishal P Varshney, Ramesh Sahjpaul, Scott Paquette, Jill Osborn, Rémi Pelletier-Roy, Michael Asmussen, Manjot Birk, Taryn Ludwig, Fred Nicholls, Ariel Zohar, Janneke Loomans, Ferran Pellise, Justin S Smith, So Kato, Zeeshan Sardar, Lawrence Lenke, Aazad Abbas, Jay Toor, Gurjovan Sahi, Dusan Kovacevic, Johnathan Lex, Raja Rampersaud, Anthony V Perruccio, Nizar Mahomed, Mayilee Canizares, Maroun Rizkallah, Michel Alexandre Lebreton, Ghassan Boubez, Jesse Shen, Fidaa Alshakfa, Yousef Kamel, Galil Osman, Zhi Wang, Nikolaus Koegl, Brandon Herrington, Renan R Fernandes, Jennifer C Urquhart, Yoga R Rampersaud, Chris S Bailey, Ramtin Hakimjavadi, Tinghua Zhang, Zachary Devries, Eugene K Wai, Stephen P Kingwell, Alexandra Stratton, Eve Tsai, Philippe Phan, Noah Fine, Laura Stone, Mohit Kapoor, Alexandre Chênevert, Sonia Bédard, Greg Mcintosh, Julien Goulet, Jérome Couture, Csorn Investigators, Bernard Larue, Brent Rosenstein, Meaghan Rye, Alexa Roussac, Neda Naghdi, Luciana G Macedo, James Elliott, Richard Demont, Michael H Weber, Véronique Pepin, Geoffrey Dover, Maryse Fortin, Edisond Florial, Aditya Raj, Prarthan Amin, Yoga Raja Rampersaud, Abdullah A S M Alduwaisan, Kim Phan, Stephen Kingwell, Eugene Wai, Jeffrey Hebert, Sarah Nowell, Niels Wedderkopp, Amanda Vandewint, Neil Manson, Edward Abraham, Christopher Small, Najmedden Attabib, Erin Bigney, Michael Craig, Abdul Al-Shawwa, Kalum Ost, Saswati Tripathy, Nathan Evaniew, Bradley Jacobs, David Cadotte, Nicolas Dea, Jefferson R Wilson, Christopher S Bailey, Y Raja Rampersaud, W Bradley Jacobs, Philippe Phan Phan, Andrew Nataraj, David W Cadotte, Kenneth C Thomas, Jerome Paquet, Sean D Christie, Hamilton Hall, Charles G Fisher, Eva Y Liu, Amit R L Persad, Nathan Baron, Daryl Fourney, Husain Shakil, Jingyi Huang, Nader Fallah, Charlotte Dandurand, Csorn Investigators, Thamer Alfawaz, Tinghua Zhang, Alexandra Stratton, Eve Tsai, Eugene Wai, Stephen Kingwell, Zhi Wang, Philippe Phan, Csorn Investigators, Julien Francisco Zaldivar-Jolissaint, Raphaële Charest-Morin, Greg Mcintosh, Michael G Fehlings, Karlo M Pedro, Mohammed Ali Alvi, Jessica C W Wang, Raphaële Charest-Morin, Nicolas Dea, Charles Fisher, Marcel Dvorak, Brian Kwon, Tamir Ailon, Scott Paquette, John Street, Charlotte Dandurand, Rohail Mumtaz, Khaled Skaik, Eugene K Wai, Stephen Kingwell, Alexandra Stratton, Eve Tsai, Philippe Tran Nhut Phan, Zhi Wang, Csorn Investigators, Ragavan Manoharan, Greg Mcintosh, Yoga R Rampersaud, Jenna Smith-Forrester, Joanne E Douglas, Evan Nemeth, Jacob Alant, Sean Barry, Andrew Glennie, William Oxner, Lutz Weise, Sean Christie, Eva Y Liu, Amit R L Persad, Sabahat Saeed, Patrick Toyota, Jack Su, Braeden Newton, Nicole Coote, Daryl Fourney, Maria S Rachevits, Helen Razmjou, Susan Robarts, Albert Yee, Joel Finkelstein, Alysa Almojuela, Frederick Zeiler, Sarvesh Logsetty, Perry Dhaliwal, Mark Abdelnour, Yuxin Zhang, Eugene Wai, Stephen P Kingwell, Alexandra Stratton, Eve Tsai, Philippe T Phan, Csorn Investigators, Taylor A Smith, Christopher Small, Erin Bigney, Eden Richardson, Jillian Kearney, Neil Manson, Edward Abraham, Najmedden Attabib, Michael Bond, Stephan Dombrowski, Gwyneth Price, Jose Manuel García-Moreno, Jeffrey Hebert, Steven Qiu, Vithushan Surendran, Victoria Shi Emily Cheung, Sophie Ngana, Muhammad A Qureshi, Sunjay V Sharma, Markian Pahuta, Daipayan Guha, Ahmad Essa, Husain Shakil, Armaan Malhotra, James Byrne, Jetan Badhiwala, Eva Yuan, Yingshi He, Andrew Jack, Francois Mathieu, Jefferson R Wilson, Christopher D Witiw, Husain Shakil, Armaan K Malhotra, Eva Yuan, Christopher W Smith, Erin M Harrington, Rachel H Jaffe, Alick P Wang, Karim Ladha, Avery B Nathens, Jefferson R Wilson, Christopher D Witiw, Ryan V Sandarage, Ahmad Galuta, Eve C Tsai, Naama Rotem-Kohavi, Marcel F Dvorak, Jijie Xu, Nader Fallah, Zeina Waheed, Melody Chen, Nicolas Dea, Nathan Evaniew, Vanessa Noonan, Brian Kwon, Brian K Kwon, Toluyemi Malomo, Raphaële Charest-Morin, Scott Paquette, Tamir Ailon, Charlotte Dandurand, John Street, Charles G Fisher, Nicolas Dea, Manraj Heran, Marcel Dvorak, Rachael Jaffe, Peter Coyte, Brian Chan, Armaan Malhotra, Rebecca Hancock-Howard, Jefferson Wilson, Christopher Witiw, Newton Cho, Jordan Squair, Viviana Aureli, Nicholas James, Lea Bole-Feysot, Inssia Dewany, Nicolas Hankov, Laetitia Baud, Anna Leonhartsberger, Kristina Sveistyte, Michael Skinnider, Matthieu Gautier, Katia Galan, Maged Goubran, Jimmy Ravier, Frederic Merlos, Laura Batti, Stéphane Pagès, Nadia Bérard, Nadine Intering, Camille Varescon, Stefano Carda, Kay Bartholdi, Thomas Hutson, Claudia Kathe, Michael Hodara, Mark Anderson, Bogdan Draganski, Robin Demesmaeker, Leonie Asboth, Quentin Barraud, Jocelyne Bloch, Grégoire Courtine, Sean D Christie, Ryan Greene, Mustafa Nadi, Jacob Alant, Sean Barry, Andrew Glennie, Bill Oxner, Lutz Weise, Lisa Julien, Clara Lownie, Marcel F Dvorak, Cumhur F C Öner, Charlotte Dandurand, Alexander Joeris, Klaus Schnake, Mark Phillips, Alexander R Vaccaro, Richard Bransford, Eugen Cezar Popescu, Mohammed El-Sharkawi, Shanmuganathan Rajasekaran, Lorin M Benneker, Greg D Schroeder, Jin W Tee, John France, Jérôme Paquet, Richard Allen, William F Lavelle, Emiliano Vialle, Nicolas Dea, Antoine Dionne, David Magnuson, Andréane Richard-Denis, Yvan Petit, Francis Bernard, Dorothy Barthélémy, Jean-Marc Mac-Thiong, Lukas Grassner, Daniel Garcia-Ovejero, Evelyn Beyerer, Orpheus Mach, Iris Leister, Doris Maier, Ludwig Aigner, Angel Arevalo-Martin, Mark Alexander Maclean, Antoinette Charles, Miltiadis Georgiopoulos, Raphaële Charest-Morin, Rory Goodwin, Michael Weber, Emile Brouillard, Andréane Richard-Denis, Antoine Dionne, Ismail Laassassy, Paul Khoueir, Étienne Bourassa-Moreau, Gilles Maurais, Jean-Marc Mac-Thiong, Julien Francisco Zaldivar-Jolissaint, Nicolas Dea, Aysha Allard Brown, Kitty So, Neda Manouchehri, Megan Webster, Jay Ethridge, Audrey Warner, Avril Billingsley, Rochelle Newsome, Kirsten Bale, Andrew Yung, Mehara Seneviratne, Jimmy Cheng, Jing Wang, Shenani Basnayake, Femke Streijger, Manraj Heran, Piotr Kozlowski, Brian K Kwon, Jeff D Golan, Lior M Elkaim, Qais Alrashidi, Miltiadis Georgiopoulos, Oliver J Lasry, Drew A Bednar, Alyson Love, Soroush Nedaie, Pranjan Gandhi, Prarthan C Amin, Aditya Raj, Greg Mcintosh, Christopher J Neilsen, Ganesh Swamy, Raja Rampersaud, Amanda Vandewint, Y Raja Rampersaud, Jeffrey Hebert, Erin Bigney, Neil Manson, Najmedden Attabib, Chris Small, Eden Richardson, Jill Kearney, Edward Abraham, Raja Rampersaud, Aditya Raj, Nanadan Marathe, Greg Mcintosh, Manmeet Dhiman, Taylor J Bader, David Hart, Ganesh Swamy, Neil Duncan, Manmeet Dhiman, Taylor J Bader, Dragana Ponjevic, John R Matyas, David Hart, Ganesh Swamy, Neil Duncan, Connor P O'Brien, Jeffrey Hebert, Erin Bigney, Jillian Kearney, Eden Richardson, Edward Abraham, Neil Manson, Najmedden Attabib, Christopher Small, Luke Larochelle, Gabriella Rivas, James Lawrence, Robert Ravinsky, Dorothy Kim, Jennifer Dermott, Aya Mitani, Andrea Doria, Andrew Howard, David Lebel, Jennifer A Dermott, Lily S Switzer, Dorothy J Kim, David E Lebel, Chanelle Montpetit, Nicolas Vaillancourt, Brent Rosenstein, Maryse Fortin, Emma Nadler, Jennifer Dermott, Dorothy Kim, David E Lebel, Daniel Wolfe, Brent Rosenstein, Maryse Fortin, Daniel Wolfe, Geoffrey Dover, Mathieu Boily, Maryse Fortin, Husain Shakil, Armaan K Malhotra, Jetan H Badhiwala, Vishu Karthikeyan, Yingshi He, Michael G Fehlings, Arjun Sahgal, Nicolas Dea, Alex Kiss, Christopher D Witiw, Donald R Redelmeier, Jefferson R Wilson, Marco Pérez Caceres, Véronique Freire, Jesse Shen, Fidaa Al-Shakfa, Omer Ahmed, Zhi Wang, William Chu Kwan, Scott L Zuckerman, Charles G Fisher, Ilya Laufer, Dean Chou, John E O'Toole, Markus Schultheiss, Michael H Weber, Daniel M Sciubba, Markian Pahuta, John H Shin, Michael G Fehlings, Anne Versteeg, Matthew L Goodwin, Stefano Boriani, Chetan Bettegowda, Aron Lazary, Alessandro Gasbarrini, Jeremy J Reynolds, Jorrit-Jan Verlaan, Arjun Sahgal, Ziya L Gokaslan, Laurence D Rhines, Nicolas Dea, Van Tri Truong, The Khanh Dang, Galil Osman, Fidaa Al-Shakfa, Danielle Boule, Jesse Shen, Zhi Wang, Maroun Rizkallah, Ghassan Boubez, Jesse Shen, Philippe Phan, Fidaa Alshakfa, Danielle Boule, Celine Belguendouz, Rayane Kafi, Sung-Joo Yuh, Daniel Shedid, Zhi Wang, Zhi Wang, Jesse Shen, Ghassan Boubez, Fidaa Alshakfa, Daniele Boulé, Celine Belguendouz, Rayane Kafi, Philippe Phan, Daniel Shedid, Sung-Joo Yuh, Maroun Rizkallah, Yan Gabriel Morais David Silva, Luis Weber, Felipe Leão, Ahmad Essa, Armaan K Malhotra, Husain Shakil, James Byrne, Jetan Badhiwala, Avery B Nathens, Tej D Azad, Eva Yuan, Yingshi He, Andrew S Jack, Francois Mathieu, Jefferson R Wilson, Christopher D Witiw, Michael Craig, Nick Guenther, Jan Valosek, Maxime Bouthillier, Naga Karthik Enamundram, Naama Rotem-Kohavi, Suzanne Humphreys, Sean Christie, Michael Fehlings, Brian Kwon, Jean-Marc Mac-Thiong, Philippe Phan, Jerome Paquet, Mathieu Guay-Paquet, Julien Cohen-Adad, David Cadotte, Antoine Dionne, Jean-Marc Mac-Thiong, Heather Hong, Dilnur Kurban, Jijie Xu, Dorothy Barthélémy, Sean Christie, Daryl Fourney, Gary Linassi, Adalberto Loyola Sanchez, Jérôme Paquet, Vidya Sreenivasan, Andrea Townson, Eve C Tsai, Andréane Richard-Denis, William Chu Kwan, Pedram Laghaei, Harsh Kahlon, Tamir Ailon, Raphael Charest-Morin, Charlotte Dandurand, Scott Paquette, Nicholas Dea, John Street, Charles G Fisher, Marcel F Dvorak, Brian K Kwon, Jérémie Thibault, Antoine Dionne, Mohamed Al-Sofyani, Rémi Pelletier-Roy, Andréane Richard-Denis, Étienne Bourassa-Moreau, Jean-Marc Mac-Thiong, Maxime Bouthillier, Jan Valošek, Naga Karthik Enamundram, Mathieu Guay-Paquet, Nick Guenther, Naama Rotem-Kohavi, Suzanne Humphreys, Sean Christie, Michael Fehlings, Brian K Kwon, Jean Marc Mac-Thiong, Philippe Phan, David Cadotte, Julien Cohen-Adad, Luke Reda, Colton Kennedy, Stephanie Stefaniuk, Parvin Eftekhar, Larry Robinson, Cathy Craven, Jana Dengler, Colton Kennedy, Luke Reda, Stephanie Stefaniuk, Parvin Eftekhar, Larry Robinson, Cathy Craven, Jana Dengler, Maryam Rezaeezadeh Roukerd, Maitreya Patel, Eve Tsai, Ahmad Galuta, Sasi Jagadeesan, Ryan Vimukthie Sandarage, Philippe Phan, Wojtek Michalowski, William Van Woensel, Khushdeep Vig, Jillian Kazley, Abdul Arain, Gabriella Rivas, Robert Ravinsky, James Lawrence, Shaurya Gupta, Jibrahn Patel, Isaac Turkstra, Kirill Pustovetov, Victor Yang, W Bradley Jacobs, Gonzalo Mariscal, Christopher D Witiw, James S Harrop, Ahmed Essa, Christopher D Witiw, Gonzalo Mariscal, W Bradley Jacobs, James S Harrop, Ahmed Essa, Jin Tong Du, Ahmed Cherry, Rajesh Kumar, Nadia Jaber, Michael Fehlings, Albert Yee, Siril Teja Dukkipati, Mark Driscoll, Elizabeth Byers, Justin L Brown, Michelle Gallagher, James Sugar, Shannon Rockall, James Hektner, Scott Donia, John Chernesky, Vanessa K Noonan, Aaron A Varga, Flo Slomp, Emily Thiessen, Nataliya Lastivnyak, Linda Slater Maclean, Vanessa Ritchie, Aaron Hockley, Lutz M Weise, Christine Potvin, Peggy Flynn, Sean Christie, Isaac Turkstra, Bruno Oppermann, Marcelo Oppermann, Shaurya Gupta, Jibrahn Patel, Kirill Pustovetov, Kenneth Lee, Chaoliang Chen, Mohammadmahdi Rastgarjazi, Victor Yang, Sarah Hardy, Samuel Strantzas, Alison Anthony, Jennifer Dermott, Mike Vandenberk, Samer Hassan, David Lebel, Yan Gabriel Morais David Silva, Bernard Larue, Jerome Couture, Newton Pimenta, Jocelyn Blanchard, Alexandre Chenevert, Julien Goulet, Ryan Greene, Sean D Christie, Amanda Hall, Holly Etchegary, Alwalaa Althagafi, Jae Han, Ryan Greene, Sean Christie, Gwynedd Pickett, Christopher Witiw, James Harrop, W Bradley Jacobs, Gonzalo Mariscal, Ahmed Essa, W Bradley Jacobs, Gonzalo Mariscal, Christopher Witiw, James S Harrop, Ahmed Essa, Timothy Lasswell, Parham Rasoulinejad, Richard Hu, Chris Bailey, Fawaz Siddiqi, Abdulrahman Hamdoon, Mohamed Amin Soliman, Juhi Maraj, Deven Jhawar, Balraj Jhawar, Kirsten A Schuler, Lindsay D Orosz, Tarek Yamout, Brandon J Allen, Wondwossen T Lerebo, Rita T Roy, Thomas C Schuler, Christopher R Good, Colin M Haines, Ehsan Jazini, Kalum J Ost, Abdul Al-Shawwa, David Anderson, Nathan Evaniew, Bradley W Jacobs, Peter Lewkonia, Fred Nicholls, Paul T Salo, Kenneth C Thomas, Michael Yang, David Cadotte, Mohamed Sarraj, Nathasha Rajapaksege, Nicolas Dea, Nathan Evaniew, Greg Mcintosh, Markian Pahuta, Hani Nouran Alharbi, Khaled Skaik, Eugene K Wai, Stephen Kingwell, Alexandra Stratton, Eve Tsai, Philippe Tran Nhut Phan, Zhi Wang, Csorn Investigators, Julien Francisco Zaldivar-Jolissaint, Sara Gustafson, Ian Polyzois, Trevor Gascoyne, Michael Goytan, Drew Alexander Bednar, Mohamed Sarra, Brett Rocos, Juan P Sardi, Anastasios Charalampidis, Jeff Gum, Stephen J Lewis, Ravi Ghag, Samuel Kirk, Otis Shirley, Jeffrey Bone, Andrew Morrison, Firoz Miyanji, Amit Parekh, Ethan Sanders, Manjot Birk, Fred Nicholls, Kevin Smit, Holly Livock, Jessica Romeo, James Jarvis, Andrew Tice, Sofía Frank, Hubert Labelle, Stephan Parent, Soraya Barchi, Julie Joncas, Jean-Marc Mac-Thiong, Jérémie Thibault, Julie Joncas, Soraya Barchi, Stefan Parent, Marie Beausejour, Jean-Marc Mac-Thiong, Antoine Dionne, Jean-Marc Mac-Thiong, Stefan Parent, Jesse Shen, Julie Joncas, Soraya Barchi, Hubert Labelle, Manjot S Birk, Fred Nicholls, Rémi Pelletier-Roy, Ethan Sanders, Stephen Lewis, Yousef Aljamaan, Lawrence G Lenke, Justin Smith, Zeeshan Sardar, Elen Mullaj, David Lebel, Jennifer Dermott, Natasha Bath, Karen Mathias, Deepa Kattail, Ariel Zohar, Janneke Loomans, Ferran Pellise, Justin S Smith, So Kato, Zeeshan Sardar, Lawrence Lenke, Stephen J Lewis, Taylor J Bader, Manmeet Dhiman, David Hart, Neil Duncan, Paul Salo, Ganesh Swamy, Stephen Joel Lewis, Peyton Lloyd Lawrence, Justin Smith, Ferran Pellise, Zeeshan Sardar, Peyton Lloyd Lawrence, Stephen Joel Lewis, Justin Smith, Ferran Pellise, Zeeshan Sardar, Jordan J Levett, Abdulrhman Alnasser, Uri Barak, Lior M Elkaim, Thien Sa Hoang, Naif M Alotaibi, Daipayan Guha, Isaac L Moss, Alexander G Weil, Michael H Weber, Phillip De Muelenaere, Kashif Parvez, John Sun, Olivia C Iorio, Brent Rosenstein, Neda Naghdi, Maryse Fortin, Felicia Manocchio, Ran Ankory, Lisa Stallwood, Henry Ahn, Hamza Mahdi, Abdul Naeem, Deven Jhawar, Milad Moradi, Balraj Jhawar, Steven Qiu, Vithushan Surendran, Victoria Shi, Emily Cheung, Sophie Ngana, Muhammad A Qureshi, Sunjay V Sharma, Markian Pahuta, Daipayan Guha

Faculty, Staff and Student Publications

No abstract provided.

Deep Filtered Back Projection For Ct Reconstruction, X I Tan, Xuan Liu, Kai Xiang, Jing Wang, Shan Tan

Faculty, Staff and Student Publications

Filtered back projection (FBP) is a classic analytical algorithm for computed tomography (CT) reconstruction, with high computational efficiency. However, images reconstructed by FBP often suffer from excessive noise and artifacts. The original FBP algorithm uses a window function to smooth signals and a linear interpolation to estimate projection values at un-sampled locations. In this study, we propose a novel framework named DeepFBP in which an optimized filter and an optimized nonlinear interpolation operator are learned with neural networks. Specifically, the learned filter can be considered as the product of an optimized window function and the ramp filter, and the learned …

Registration Of Hyperspectral Images And Mass Spectrometry Data For The Correlation Of Tissue Optical Spectra And Molecular Profiles, Angie T Fei, Douglas W Strand, Jing Wang

Faculty, Staff and Student Publications

Hyperspectral imaging (HSI) is a label-free imaging modality that is emerging for non-invasive detection of various diseases including cancers. HSI provides high-resolution spatial images where each pixel has a spectral curve with numerous wavelength bands from the visible to infrared ranges. The rich spatial and spectral information can be used to discriminate various types of tissues and pathophysiological conditions. However, it can be difficult to explain spectral data with respect to the underline cellular and molecular mechanism. In this study, we developed an approach that registers hyperspectral images and mass spectrometry (MS) data where MS provides tissue molecular profiles. Human …

Refinement Of An Emergency Department-Based, Advance Care Planning Intervention For Patients With Cognitive Impairment And Their Caregivers, Kei Ouchi, Christopher Joshi, Jenson Kaithamattam, Seth A Gale, Gad A Marshall, Alison Pietras, Wei Wang, Edward W Boyer, James A Tulsky, Susan D Block, Dorene Rentz, Mara A Schonberg

Faculty, Staff and Student Publications

Background and objectives: Advance care planning (ACP) conversations are important to provide goal-concordant care (i.e., the care that matches the patient's previously stated goals) near end of life. While 31% of older adults presenting to the emergency department (ED) have dementia, only 39% have previously had ACP conversations. We refined and piloted an ED-based, motivational interview designed to stimulate ACP conversations (ED GOAL) for patients living with cognitive impairment and their caregivers.

Research design and methods: We systematically refined ED GOAL and then conducted an acceptability study in an urban, academic medical center. We prospectively enrolled adults aged 50+ with …

Editorial: Immunological Aspects Of Emerging And Re-Emerging Zoonoses, Wei Wang, Jingxin Li, Yuejin Liang, Wenping Gong

Faculty, Staff and Student Publications

No abstract provided.

Unicentric Castleman Disease: Illustration Of Its Morphologic Spectrum And Review Of The Differential Diagnosis, Siba El Hussein, Andrew G Evans, Hong Fang, Wei Wang, L Jeffrey Medeiros

Faculty, Staff and Student Publications

Context: Unicentric Castleman disease (UCD) is a dynamic entity with a wide spectrum of morphologic findings. UCD can be further subdivided into hyaline-vascular and mixed/plasmacytic variants. Hyaline-vascular UCD has both follicular and interfollicular (stromal) changes, and occasionally these lesions show a skewed representation of either the follicular or stromal compartments. Plasmacytosis is usually minimal in the hyaline-vascular variant. The mixed/plasmacytic variant of UCD is composed of sheets of plasma cells often associated with a variable number of follicles with regressive changes.

Objective: To illustrate the differential diagnosis of UCD, as it is quite broad and includes lymphomas, plasma cell neoplasms, …

Highly Variable Timing Renders Immunotherapy Efficacy And Toxicity Impractical Biomarkers Of One Another In Clinical Practice, Mitchell S Von Itzstein, Yuqiu Yang, Yiqing Wang, David Hsiehchen, Thomas Y Sheffield, Farjana Fattah, Vinita Popat, Murtaza Ahmed, Jade Homsi, Jonathan E Dowell, Sawsan Rashdan, Jay Lohrey, Hans J Hammers, Randall S Hughes, Tao Wang, Yang Xie, David E Gerber

Faculty, Staff and Student Publications

Background: A useful clinical biomarker requires not only association but also a consistent temporal relationship. For instance, chemotherapy-induced neutropenia and epidermal growth-factor inhibitor-related acneiform rash both occur within weeks of treatment initiation, thereby providing information prior to efficacy assessment. Although immune checkpoint inhibitor (ICI)-associated immune-related adverse events (irAE) have been associated with therapeutic benefit, irAE may have delayed and highly variable onset. To determine whether ICI efficacy and irAE could serve as clinically useful biomarkers for predicting each other, we determined the temporal relationship between initial efficacy assessment and irAE onset in a diverse population treated with ICI.

Methods: Using …

Foxp1 And Klf2 Reciprocally Regulate Checkpoints Of Stem-Like To Effector Transition In Car T Cells, Ziang Zhu, Guohua Lou, Xiao-Lu Teng, Haixia Wang, Ying Luo, Wangke Shi, Kiddist Yihunie, Shumeng Hao, Kole Degolier, Chengheng Liao, Huocong Huang, Qing Zhang, Terry Fry, Tao Wang, Chen Yao, Tuoqi Wu

Faculty, Staff and Student Publications

During cancers and infections, self-renewing stem-like CD8+ T cells mediate the response of immunotherapies and replenish terminally exhausted T cells and effector-like T cells. However, the programs governing the lineage choice in chimeric antigen receptor (CAR) T cells are unclear. Here, by simultaneously profiling single-cell chromatin accessibility and transcriptome in the same CAR T cells, we identified heterogeneous chromatin states within CD8+ T cell subsets that foreshadowed transcriptional changes and were primed for regulation by distinct transcription factors. Transcription factors that controlled each CD8+ T cell subset were regulated by high numbers of enhancers and positioned as hubs of gene …

Editorial: Advances And Methods In Mesenchymal Stem Cells, Pamela L Wenzel

Faculty, Staff and Student Publications

No abstract provided.

An Image-Driven Micromechanical Approach To Characterize Multiscale Remodeling In Infarcted Myocardium, Emilio A Mendiola, Sunder Neelakantan, Qian Xiang, Shuda Xia, Jianyi Zhang, Vahid Serpooshan, Peter Vanderslice, Reza Avazmohammadi

Faculty, Staff and Student Publications

Myocardial infarction (MI) is accompanied by the formation of a fibrotic scar in the left ventricle (LV) and initiates significant alterations in the architecture and constituents of the LV free wall (LVFW). Previous studies have shown that LV adaptation is highly individual, indicating that the identification of remodeling mechanisms post-MI demands a fully subject-specific approach that can integrate a host of structural alterations at the fiber-level to changes in bulk biomechanical adaptation at the tissue-level. We present an image-driven micromechanical approach to characterize remodeling, assimilating new biaxial mechanical data, histological studies, and digital image correlation data within an in-silico framework …

Perceptions Of The Addictiveness Of Low-Nicotine Cigarettes Versus Typical Cigarettes And Exposure To Tobacco Industry-Sponsored Corrective Campaign, Onyema Greg Chido-Amajuoyi, Dale S Mantey, Efehi Igbinomwanhia, Onyinye Omega-Njemnobi, Henry Onyeaka, Robert K Yu, Israel Agaku, Sanjay Shete

Faculty, Staff and Student Publications

Background: In 2017, the U.S. Food and Drug Administration (FDA) announced a regulatory plan to reduce the nicotine content of cigarettes. This study examines the association of exposure to industry-sponsored corrective statements on perceptions of the addictiveness of low-nicotine cigarettes relative to typical cigarettes within the general US population.

Methods: The study comprised 4975 US adult respondents of the 2019 Health Information National Trends Survey (HINTS 5, Cycle 3). Multinomial logistic regression models were used to examine associations between exposure to tobacco industry corrective messages and perceptions of the addictiveness of low-nicotine cigarettes relative to typical cigarettes.

Results: In the …

Explainable Suicide Phenotyping From Initial Psychiatric Evaluation Notes Using Reasoning Large Language Models, Zehan Li, Wanjing Wang, Lokesh Shahani, Rodrigo M Vieira, Salih Selek, Jair Soares, Hongfang Liu, Ming Huang

Faculty, Staff and Student Publications

Clinical phenotyping is the process of extracting patient's observable symptoms and traits to better understand their disease condition. Suicide phenotyping focuses more on behavioral and cognitive characteristics, such as suicide ideation, attempt, and self-injury, to identify suicide risks and improve interventions. In this study, we leveraged the latest reasoning models, namely 4o, o1, and o3-mini, to perform note-level multi-label classification and reasoning generation tasks using previously annotated psychiatric evaluation notes from a safety-net psychiatric inpatient hospital in Harris County, Texas. Compared with the previously finetuned GPT-3.5 model, the out-of-box reasoning models prompted with in-context learning achieved comparable and better performance, …

Monet: A Database For Prediction Of Neoantigens Derived From Microsatellite Loci, Nan Deng, Krishna M Sinha, Eduardo Vilar

Faculty, Staff and Student Publications

BACKGROUND: Microsatellite instability (MSI) secondary to mismatch repair (MMR) deficiency is characterized by insertions and deletions (indels) in short DNA sequences across the genome. These indels can generate neoantigens, which are ideal targets for precision immune interception. However, current neoantigen databases lack information on neoantigens arising from coding microsatellites. To address this gap, we introduce The MicrOsatellite Neoantigen Discovery Tool (MONET).

METHOD: MONET identifies potential mutated tumor-specific neoantigens (neoAgs) by predicting frameshift mutations in coding microsatellite sequences of the human genome. Then MONET annotates these neoAgs with key features such as binding affinity, stability, expression, frequency, and potential pathogenicity using …

Are Published Cancer Care Trial Protocols With Traditional Chinese Medicine Interventions Concordant With Spirit-Tcm Extension 2018? A Scoping Review On Published Trial Protocols Between 2019 And 2022, Hezheng Lai, Peiying Yang, Xin Shelley Wang, David Lim, Anderson Lam, Yucong Shi, Yishi Huang, Xiaoshu Zhu

Faculty, Staff and Student Publications

BACKGROUND: The SPIRIT-TCM Extension 2018 was created to guide the design and reporting of Traditional Chinese Medicine (TCM) clinical trial protocols. This study aims to investigate the extent of concordance with this guideline in the relevant field of cancer care research.

METHODS: A scoping review of TCM cancer trial protocols published in English and Chinese since January 2019 was conducted. Five major academic databases (MEDLINE, EMBASE, CINAHL, CENTRAL, and China National Knowledge Infrastructure) were searched. Concordance with the SPIRIT-TCM Extension 2018 was assessed by descriptive analysis.

RESULTS: Fifty-three TCM cancer care trial protocols were identified, comprising 23 acupuncture, 26 Chinese …

Postmortem-Derived Ipsc Models In Substance Use Disorders Research, Emily Frances Mendez, Consuelo Walss-Bass

Faculty, Staff and Student Publications

No abstract provided.