Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Systems Biology
Exploring The Biogeography Of South American Rainforest Understory Birds Using Morphological Variation In The Wedge-Billed Woodcreeper ( Glyphorynchus Spirurus ), Gregory Tito
Theses and Dissertations
Tropical rainforests in the Amazon Basin show an extraordinarily high degree of biodiversity, the reasons for which are poorly understood. A number of biogeographical models have been proposed to account for the variation present within and among species, including birds. This study tests the predictive ability of six major historical vicariant biogeographical models (Andean uplift, marine incursion, Amazonian lake, river barrier, refuge, and river refuge) using a large data set of morphological characters in the Wedge-billed Woodcreeper (Glyphorynchus spirurus), a small understory songbird found mostly in terra firme tropical rain forest. It also characterizes variation in key morphological characters and …
Network Analytics For The Mirna Regulome And Mirna-Disease Interactions, Joseph Jayakar Nalluri
Network Analytics For The Mirna Regulome And Mirna-Disease Interactions, Joseph Jayakar Nalluri
Theses and Dissertations
miRNAs are non-coding RNAs of approx. 22 nucleotides in length that inhibit gene expression at the post-transcriptional level. By virtue of this gene regulation mechanism, miRNAs play a critical role in several biological processes and patho-physiological conditions, including cancers. miRNA behavior is a result of a multi-level complex interaction network involving miRNA-mRNA, TF-miRNA-gene, and miRNA-chemical interactions; hence the precise patterns through which a miRNA regulates a certain disease(s) are still elusive. Herein, I have developed an integrative genomics methods/pipeline to (i) build a miRNA regulomics and data analytics repository, (ii) create/model these interactions into networks and use optimization techniques, motif …