Open Access. Powered by Scholars. Published by Universities.®
Animal Experimentation and Research Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Keyword
-
- BDNF (1)
- Behavior (1)
- Brain-derived neurotrophic factor (BDNF) (1)
- Dog (1)
- GPS tracking (1)
-
- Human subject research (1)
- Information literacy (1)
- Interdisciplinary learning (1)
- Kinesin (1)
- Library instruction (1)
- MRNA localization (1)
- Multivariate analysis (1)
- Neuron (1)
- Open field activity (1)
- PAT1 (1)
- RNA interference (RNAi) (1)
- Research ethics (1)
- Responsible conduct of research (1)
- Synapse (1)
- ZBP1 (1)
Articles 1 - 3 of 3
Full-Text Articles in Animal Experimentation and Research
Multivariate Analysis Of Open Field Exploration Identifies Latent Spatial And Social Behavioral Axes In Domestic Dogs, Budhaditya Chowdhury, Moira Van Staaden, Robert Huber
Multivariate Analysis Of Open Field Exploration Identifies Latent Spatial And Social Behavioral Axes In Domestic Dogs, Budhaditya Chowdhury, Moira Van Staaden, Robert Huber
Advanced Science Research Center
Recent methodological advances in studying large scale animal movements have let researchers gather rich datasets from behaving animals. Often collected in small sample sizes due to logistical constraints, these datasets are however, ideal for multivariate explorations into behavioral complexity. In behavioral studies of domestic dogs, although automated data loggers have recently seen increasing use, a comprehensive framework to identify complex behavioral axes is lacking. Dog behavioral studies frequently rely on subjective ratings, despite demonstrable evidence that these are insufficient for identifying behavioral variables. Taking advantage of dogs’ innate running abilities and readily available GPS data loggers, we extracted latitude-longitude coordinates …
A Kinesin Adapter Directly Mediates Dendritic Mrna Localization During Neural Development In Mice, Hao Wu, Jing Zhou, Tianhui Zhu, Ivan Cohen, Jason Dictenberg
A Kinesin Adapter Directly Mediates Dendritic Mrna Localization During Neural Development In Mice, Hao Wu, Jing Zhou, Tianhui Zhu, Ivan Cohen, Jason Dictenberg
Publications and Research
Motor protein-based active transport is essential for mRNA localization and local translation in animal cells, yet how mRNA granules interact with motor proteins remains poorly understood. Using an unbiased yeast two–hybrid screen for interactions between murine RNA-binding proteins (RBPs) and motor proteins, here we identified protein interaction with APP tail-1 (PAT1) as a potential direct adapter between zipcode-binding protein 1 (ZBP1, a β-actin RBP) and the kinesin-I motor complex. The amino acid sequence of mouse PAT1 is similar to that of the kinesin light chain (KLC), and we found that PAT1 binds to KLC directly. Studying PAT1 in mouse …
Inducing Application Of Interdisciplinary Frameworks: Experiences From The Domains Of Information Literacy And Responsible Conduct Of Research, Anne E. Leonard, Jean E. Hillstrom
Inducing Application Of Interdisciplinary Frameworks: Experiences From The Domains Of Information Literacy And Responsible Conduct Of Research, Anne E. Leonard, Jean E. Hillstrom
Publications and Research
Constructivist frameworks for information literacy and research ethics can be developed and nurtured in the context of an interdisciplinary course. Using the frameworks of two disciplines, students went on an experiential journey in support of ethics foundations through guest lectures and active learning exercises. This study describes the development and content of the responsible conduct of research and information literacy modules and discusses the role of each in an interdisciplinary course. Learning goals for both modules were evaluated by examining student responses in a free-writing exercise at the end of the semester, concluding with a discussion of the structural and …