Research Methods in Life Sciences Commons^™

The Effect Of Post-Operative Use Of Chlorhexidine On Periodontal Regeneration In Monkeys With Chronic Bifurcation Defects, J. Pat Bishop

Loma Linda University Electronic Theses, Dissertations & Projects

Periodontal regeneration and inflammation was evaluated histometrically in 36 paired teeth in six macque(sic) monkeys with chronic bifurcation defects. Daily topical TL Chlorhexidine was applied to one-half of the teeth, saline to the other half for six weeks after the bifurcation defects were surgically debrided. Measurements were made from a section taken from the mid-bifurcation for each tooth. The results demonstrated no significant difference in the area of inflammatory response or the degree of regenerative capacity of post-operative healing between Chlorhexidine treated and paired nontreated control teeth.

Viability Of Dentin In Rats Incisors : Fluid Movement In Pulpless, Endodontically Treated, And Normal Teeth In Rats, Maria Luisa Canales

Loma Linda University Electronic Theses, Dissertations & Projects

It is a well established fact that there is a fluid transport system through the dentin, however to the present time very little has been done regarding this system in teeth that have been endodontically treated.

The present work was conducted in vivo using the lower incisors of rats as the medium for the study.

A selected number of Sprague Dawley rats (36 animals), whose average age was 60 days, and whose body weight averaged about 180 grams, were given an anesthetic of Sodium Pentabarbitol, .05 to .07 ml. per 100 grams body weight. This anesthetic was injected intraperitoneally.

The …

Effect Of Post-Operative Use Of Chlorhexidine On Regeneration Of Bifurcation Defects In Dogs, Gary Bogle

Loma Linda University Electronic Theses, Dissertations & Projects

The daily post-operative use of topical chlorhexidine application has been compared to daily toothbrushing. Periodontal defects were experimentally created in the bifurcations of lower premolars in dogs. The defects were treated by surgical debridement. Chlorhexidine application and toothbrushing were performed post-operatively for six weeks on contralateral pairs of teeth. The amounts of connective tissue and bone regeneration were evaluated from microscopic sections of the bifurcation areas. No difference between chlorhexidine and tooth brushing was found for the connective tissue attachment. However, significantly more bone had regenerated in the chlorhexidine treated areas than the tooth brushed area.