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Physiology Commons

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Department of Neuroscience, Cell Biology, and Physiology

2020

Articles 1 - 4 of 4

Full-Text Articles in Physiology

Exploring The Impact Of Affective Processing On Visual Perception Of Large-Scale Spatial Environments, Auroabah S. Almufleh Jan 2020

Exploring The Impact Of Affective Processing On Visual Perception Of Large-Scale Spatial Environments, Auroabah S. Almufleh

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This thesis explores the interaction between emotions and visual perception using large scale spatial environment as the medium of this interaction. Emotion has been documented to have an early effect on scene perception (Olofsson, Nordin, Sequeira, & Polich, 2008). Yet, most popularly-used scene stimuli, such as the IAPS or GAPED stimulus sets often depict salient objects embedded in naturalistic backgrounds, or “events” which contain rich social information, such as human faces or bodies. And thus, while previous studies are instrumental to our understanding of the role that social-emotion plays in visual perception, they do not isolate the effect of emotion …


Divalent Metal Cation Entry And Cytotoxicity In Jurkat T Cells: Role Of Trpm7 Channels, Alayna N. Mellott Jan 2020

Divalent Metal Cation Entry And Cytotoxicity In Jurkat T Cells: Role Of Trpm7 Channels, Alayna N. Mellott

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Humans are exposed daily to a variety of metals that can be harmful to our immune system. Although certain divalent metal cations are essential for numerous cellular functions and are critical trace elements in humans, the uptake mechanisms of these ions remain mostly unknown. Transient receptor potential melastatin 7 (TRPM7), which is expressed in a variety of human cell types, including lymphocytes and macrophages, conducts many divalent metal cations. TRPM7 channels are largely inactive under normal physiological conditions due to cytoplasmic magnesium acting as a channel inhibitor. Magnesium is a cofactor for many biochemical reactions. Low serum levels of magnesium, …


Artificially-Generated Scenes Demonstrate The Importance Of Global Properties During Early Scene Perception, Mavuso Wesley Mzozoyana Jan 2020

Artificially-Generated Scenes Demonstrate The Importance Of Global Properties During Early Scene Perception, Mavuso Wesley Mzozoyana

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During scene perception, studies have shown the importance of the global distribution of a scene. Electrophysiological studies have found these global effects concentrated corresponding to the second positive and first negative peaks (P2 and N1, respectively) of the Event-related potential (ERP) during the first 600 ms of scene perception. We sought to understand in Experiment 1, to what extent early responses to scenes were driven by mid-level global information such as the degree of naturalness or openness in a scene image in the absence of specific low-and high-level information (color and semantic object detail). This was done using artificially-generated stimuli …


Protocol Development And Optimization For Rnls Mouse Characteristic Assessment, Hasan Farid Jan 2020

Protocol Development And Optimization For Rnls Mouse Characteristic Assessment, Hasan Farid

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Protocol development and optimization are vital in the scientific method process. By having accurate protocols, one can properly assess the characteristics of their animal model for any given experiment. One animal newly adopted in our lab was the novel regulatable nuclear localization sequence (rNLS) mouse model. This novel mouse model displays symptoms of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal dementia (FTD), after the accumulation of the hTDP-43 (TAR DNA-binding protein 43) aggregate in the central nervous system. The expression of this protein occurs after the removal of deoxycycline from the mouse’s food source. Once the removal of the drug, this …