Physiology Commons^™

Different Expression Of Placental Pyruvate Kinase M2 In Normal, Preeclamptic, And Intrauterine Growth Restriction Pregnancies, Brigham L. Bahr

Theses and Dissertations

This thesis will be organized into two chapters discussing the placental expression of two proteins, pyruvate kinase M2 (PKM2) and heat shock protein 27 (HSP 27), in human placentas. Understanding the mechanisms of placental metabolism in healthy and diseased placentas helps us understand how placenta disorders occur and how we can treat these disorders. The goal is to investigate these proteins to gain an understanding of their roles in placental disorders and help decrease maternal and fetal mortality rates. Chapter one covers the background of pyruvate kinase M2 (PKM2) in cancer and embryonic tissues, and the expression of PKM2 in …

The Effects Of Aging On Skeletal Muscle Ampk Activation And An Analysis Of Chronic Aicar Treatment On The Aging Phenotype, Shalene E. Hardman

Theses and Dissertations

AMP-activated protein kinase (AMPK), a metabolic regulator, acts in opposition to many of the effects of aging and may provide insights into the development of sarcopenia. However, the effect of aging on AMPK activation is unclear. The purpose of this dissertation was to: 1) clarify the controversy concerning the activation of AMPK in response to endurance-like exercise in aged skeletal muscle; 2) address mechanisms for the age-associated alterations in AMPK activation; and 3) address the known benefits of chronic AICAR treatment in aged skeletal muscle. First, to clarify the effect of age on AMPK activation, young adult (YA) (8 mo.) …

Effects Of Carbohydrate And Green Tea Co-Ingestion On Performance, Metabolism And Hormone During Cycling Exercise, Shih-Hua Fang

International Journal of Exercise Science: Conference Proceedings

It has been known that carbohydrate intake during exercise can improve athletic performance, and caffeine can extend exercise endurance. Green tea containing caffeine and various polyphenols has been suggested beneficial to athletes due to anti-oxidative and anti-inflammatory effects. Therefore, this study investigated the influence of carbohydrate and green tea co-ingestion on the performance, metabolism and hormone during high-intensity road cycling exercise.

Nine well-trained male cyclists, aged 17.8 ± 1.0 yr, participated this acute-treatment, double-blind, crossover study that included 6.4-km cycling time trial. Participants ingested carbohydrate (240 mg/kg body mass fructose and 120 mg/kg body mass glucose) without (CHO group) and …