Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Physiology
Exercise Training Prevents The Perivascular Adipose Tissue-Induced Aortic Dysfunction With Metabolic Syndrome, Evan Devallance, Kayla W. Branyan, Kent C. Lemaster, Ray Anderson, Kent L. Marshall, I. Mark Olfert, David M. Smith, Eric E. Kelly, Randy W. Bryner, Jefferson C. Frisbee, Paul D. Chantler
Exercise Training Prevents The Perivascular Adipose Tissue-Induced Aortic Dysfunction With Metabolic Syndrome, Evan Devallance, Kayla W. Branyan, Kent C. Lemaster, Ray Anderson, Kent L. Marshall, I. Mark Olfert, David M. Smith, Eric E. Kelly, Randy W. Bryner, Jefferson C. Frisbee, Paul D. Chantler
Faculty & Staff Scholarship
The aim of the study was to determine the effects of exercise training on improving the thoracic perivascularadipose tissue (tPVAT) phenotype (inflammation, oxidative stress, and proteasome function) in metabolic syn-drome and its subsequent actions on aortic function.Methods:Lean and obese (model of metabolic syndrome) Zucker rats (n=8/group) underwent 8-weeks ofcontrol conditions or treadmill exercise (70% of max speed, 1 h/day, 5 days/week). At the end of the inter-vention, the tPVAT was removed and conditioned media was made. The cleaned aorta was attached to a forcetransducer to assess endothelium-dependent and independent dilation in the presence or absence of tPVAT-conditioned media. tPVAT gene …