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Full-Text Articles in Physiology
Dietary Isoflavones Alter Regulatory Behaviors, Metabolic Hormones And Neuroendocrine Function In Long-Evans Male Rats, Edwin D. Lephart, James P. Proter, Lihong H. Bu, Trent D. Lund, Kenneth Setchell, Gina Ramoz, William R. Crowley
Dietary Isoflavones Alter Regulatory Behaviors, Metabolic Hormones And Neuroendocrine Function In Long-Evans Male Rats, Edwin D. Lephart, James P. Proter, Lihong H. Bu, Trent D. Lund, Kenneth Setchell, Gina Ramoz, William R. Crowley
Faculty Publications
Phytoestrogens derived from soy foods (or isoflavones) have received prevalent usage due to their 'health benefits' of decreasing: a) age-related diseases, b) hormone-dependent cancers and c) postmenopausal symptoms. However, little is known about the influence of dietary phytoestrogens on regulatory behaviors, such as food and water intake, metabolic hormones and neuroendocrine parameters. This study examined important hormonal and metabolic health issues by testing the hypotheses that dietary soy-derived isoflavones influence: 1) body weight and adipose deposition, 2) food and water intake, 3) metabolic hormones (i.e., leptin, insulin, T3 and glucose levels), 4) brain neuropeptide Y (NPY) levels, 5) heat production …
Androgen Receptor Expression In The Rat Prostate Is Down-Regulated By Dietary Phytoestrogens, Edwin D. Lephart, Trent D. Lund, Daniel J. Munson, Herman Aldercreutz, Robert J. Handa
Androgen Receptor Expression In The Rat Prostate Is Down-Regulated By Dietary Phytoestrogens, Edwin D. Lephart, Trent D. Lund, Daniel J. Munson, Herman Aldercreutz, Robert J. Handa
Faculty Publications
Background- It is well established that the growth of the prostate gland is a hormone-dependent phenomenon involving both androgenic and estrogenic control. Proliferation of prostate cells is, at least in part, under control of estrogen receptor beta (ER-beta). Phytoestrogens bind ER-beta with high affinity and therefore may have antiproliferative effects in the prostate. Methods- The prostates of male Long-Evans rats fed a diet high in phytoestrogens (Phyto-600) or very low levels of phytoestrogens (Phyto-free) were analyzed to determine the impact of dietary phytoestrogens on prostate weight and androgen receptor (AR) expression in the prostate. Results- Dietary phytoestrogens significantly decreased post-pubertal …