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Ca2+ Entry Units In A Superfast Fish Muscle, James Matthew Kittelberger, Clara Franzini-Armstrong, Simona Boncompagni
Ca2+ Entry Units In A Superfast Fish Muscle, James Matthew Kittelberger, Clara Franzini-Armstrong, Simona Boncompagni
Biology Faculty Publications
Over the past two decades, mounting evidence has demonstrated that a mechanism known as store-operated Ca2+ entry (SOCE) plays a crucial role in sustaining skeletal muscle contractility by facilitating Ca2+ influx from the extracellular space during sarcoplasmic reticulum (SR) Ca2+ depletion. We recently demonstrated that, in exercised fast-twitch muscle from mice, the incidence of Ca2+ entry units (CEUs), newly described intracellular junctions between dead-end longitudinal transverse tubular (T-tubule) extensions and stacks of sarcoplasmic reticulum (SR) flat cisternae, strictly correlate with both the capability of fibers to maintain contractions during fatigue and enhanced Ca2+ influx via SOCE. Here, we tested the …