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Articles 1 - 5 of 5
Full-Text Articles in Physiology
The Transcriptional Regulation Of The Human Angiotensinogen Gene After High-Fat Diet Is Haplotype-Dependent: Novel Insights Into The Gene-Regulatory Networks And Implications For Human Hypertension, A Rana, S Jain, N Puri, M Kaw, N Sirianni, D Eren, Brahma Mopidevi, Anand Kumar
The Transcriptional Regulation Of The Human Angiotensinogen Gene After High-Fat Diet Is Haplotype-Dependent: Novel Insights Into The Gene-Regulatory Networks And Implications For Human Hypertension, A Rana, S Jain, N Puri, M Kaw, N Sirianni, D Eren, Brahma Mopidevi, Anand Kumar
NYMC Faculty Publications
Single nucleotide polymorphisms (SNPs) in the human angiotensinogen (hAGT) gene may modulate its transcription and affect the regulation of blood pressure via activation of the renin-angiotensin aldosterone system (RAAS). In this regard, we have identified polymorphisms in the 2.5 Kb promoter of the hAGT gene that form two haplotype (Hap) blocks: -6A/G (-1670A/G, -1562C/T, -1561T/C) and -217A/G (-532T/C, -793A/G, -1074T/C & -1178G/A). hAGT gene with Hap -6A/-217A (Hap I) is associated with increased blood pressure whereas, Hap -6G/-217G (Hap II) is associated with normal blood pressure in human subjects. Since RAAS over activity contributes to hypertension in obesity, we have …
Phenotypically Heterogeneous Podoplanin-Expressing Cell Populations Are Associated With The Lymphatic Vessel Growth And Fibrogenic Responses In The Acutely And Chronically Infarcted Myocardium, M Cimini, A Cannata, G Pasquinelli, Marcello Rota, P Goichberg
Phenotypically Heterogeneous Podoplanin-Expressing Cell Populations Are Associated With The Lymphatic Vessel Growth And Fibrogenic Responses In The Acutely And Chronically Infarcted Myocardium, M Cimini, A Cannata, G Pasquinelli, Marcello Rota, P Goichberg
NYMC Faculty Publications
Cardiac lymphatic vasculature undergoes substantial expansion in response to myocardial infarction (MI). However, there is limited information on the cellular mechanisms mediating post-MI lymphangiogenesis and accompanying fibrosis in the infarcted adult heart. Using a mouse model of permanent coronary artery ligation, we examined spatiotemporal changes in the expression of lymphendothelial and mesenchymal markers in the acutely and chronically infarcted myocardium. We found that at the time of wound granulation, a three-fold increase in the frequency of podoplanin-labeled cells occurred in the infarcted hearts compared to non-operated and sham-operated counterparts. Podoplanin immunoreactivity detected LYVE-1-positive lymphatic vessels, as well as masses of …
Dental Topography And Microwear Texture In Sapajus Apella, Peter S. Ungar, Claire L. Hartgrove, Alexa N. Wimberly, Mark F. Teaford
Dental Topography And Microwear Texture In Sapajus Apella, Peter S. Ungar, Claire L. Hartgrove, Alexa N. Wimberly, Mark F. Teaford
Faculty Publications & Research of the TUC College of Osteopathic Medicine
Dental microwear texture pattern has been associated with aspects of diet for a broad range of mammalian taxa. The basic idea is that soft, tough foods are sheared with a steeper angle of approach between opposing occlusal surfaces, whereas hard, brittle items are crushed with forces perpendicular to those surfaces; and this difference is manifested in anisotropic, striated microwear textures for tough foods, and complex, pitted ones for hard objects. Other factors may, however, influence microwear texture pattern and confound diet signals. For example, if tooth surface slope influences angle of approach between opposing teeth, then perhaps wear-related changes in …
Dental Biotribology: Final Thoughts And Future Directions, Zhongrong Zhou, Paul Constantino, Mark Hoffman, Mugino Kubo, Gildas Merceron, Mark Purnell, Mark F. Teaford
Dental Biotribology: Final Thoughts And Future Directions, Zhongrong Zhou, Paul Constantino, Mark Hoffman, Mugino Kubo, Gildas Merceron, Mark Purnell, Mark F. Teaford
Faculty Publications & Research of the TUC College of Osteopathic Medicine
No abstract provided.
In Vivo Rates Of Dental Microwear Formation In Laboratory Primates Fed Different Food Items, Mark F. Teaford, Peter S. Ungar, Andrea B. Taylor, Callum F. Ross, Christopher J. Vinyard
In Vivo Rates Of Dental Microwear Formation In Laboratory Primates Fed Different Food Items, Mark F. Teaford, Peter S. Ungar, Andrea B. Taylor, Callum F. Ross, Christopher J. Vinyard
Faculty Publications & Research of the TUC College of Osteopathic Medicine
No abstract provided.