Physiology Commons^™

Development And Validation Of A Predictive Model Of Acute Glucose Response To Exercise In Individuals With Type 2 Diabetes, Bryan S. Gibson, Sheri R. Colberg, Paul Poirier, Denise Maria Martins Vancea, Jason Jones, Robin Marcus

Human Movement Sciences & Special Education Faculty Publications

Background: Our purpose was to develop and test a predictive model of the acute glucose response to exercise in individuals with type 2 diabetes.

Design and methods: Data from three previous exercise studies (56 subjects, 488 exercise sessions) were combined and used as a development dataset. A mixed-effects Least Absolute Shrinkage Selection Operator (LASSO) was used to select predictors among 12 potential predictors. Tests of the relative importance of each predictor were conducted using the Lindemann Merenda and Gold (LMG) algorithm. Model structure was tested using likelihood ratio tests. Model accuracy in the development dataset was assessed by leave-one-out cross-validation. …

Recycling Of Deuterium From Dideuterated Glucose During Moderate Exercise, Michael A. Horning, Sheri R. Colberg, Gretchen A. Casazza, George A. Brooks

Educational Foundations & Leadership Faculty Publications

A doubly labelled tracer molecule of glucose, [6,6^-2HJglucose, has been used to measure the rate of glucose appearance in blood due to endogenous glucose production (by the liver and kidneysj.^l,2 Considered 'non-recirculating', this tracer generally provides a realistic estimate of glucose kinetics.^2,3 Used as a dual tracer in conjunction with [l-¹³C]glucose, the extent of glucose recycling can be quantitated.^2-4 but the extent of possible recirculation of a single deuterium atom on newly formed glucose must then be considered.