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Immunolocalization Of G Protein-Coupled Estrogen Receptor In The Rat Epididymis, Griselle B. Martinez-Traverso, Christopher Pearl
Immunolocalization Of G Protein-Coupled Estrogen Receptor In The Rat Epididymis, Griselle B. Martinez-Traverso, Christopher Pearl
Peer Reviewed Articles
Background
Estrogen plays an important role in male reproduction, and males lacking estrogen signaling in the reproductive tissues are infertile. Estrogen signaling is mediated via two nuclear receptors, ERα and ERβ, but it was recently found that a G protein-coupled estrogen receptor (GPER) is present in the testis. It is believed that GPER is a membrane form of the estrogen receptor and mediates non-classical estrogen signaling. However, the cellular localization of GPER in the epididymis is unknown. Therefore, the objective of this study was to determine the cellular and regional expression of GPER in the rat epididymis.
Findings
To localize …