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Full-Text Articles in Physiology
Cortisol Production In Female Soccer Players, Katelyn Seagraves
Cortisol Production In Female Soccer Players, Katelyn Seagraves
ASPIRE 2024
Cortisol is released from the adrenal glands when there is an apparent stressor. Exercise, while beneficial, is seen as stress to the body and incites increased cortisol release. Cortisol is known to increase with exercise, and higher-intensity exercise tends to raise cortisol more compared to lower intensities. However, less is known about interval training and cortisol concentrations.
This review of literature dives into the background of cortisol: how it's produced, what systems it regulates, and differences in production based on gender, stressors, exercise intensity, and duration. This paper identifies some knowledge gaps and links training intensities in soccer to cortisol …
Cortisol Production In Female Soccer Players, Katelyn Seagraves
Cortisol Production In Female Soccer Players, Katelyn Seagraves
Honors Projects
Cortisol is released from the adrenal glands when there is an apparent stressor. Exercise, while beneficial, is seen as stress to the body and incites increased cortisol release. Cortisol is known to increase with exercise, and higher-intensity exercise tends to raise cortisol more compared to lower intensities. However, less is known about interval training and cortisol concentrations.
This review of literature dives into the background of cortisol: how it's produced, what systems it regulates, and differences in production based on gender, stressors, exercise intensity, and duration. This paper identifies some knowledge gaps and links training intensities in soccer to cortisol …
Microglial Response To Glucocorticoids During Chronic Sleep Fragmentation, Christian Chelson
Microglial Response To Glucocorticoids During Chronic Sleep Fragmentation, Christian Chelson
Masters Theses & Specialist Projects
Sleep is one of the body’s greatest and most basic needs. Chronic sleep loss (<6 hours a day) is linked to many cardiovascular issues, diabetes, and inflammatory conditions and has been shown to lower life expectancy. Obstructive sleep apnea (OSA) is a complication that causes sleep fragmentation in >8% of adults from developed countries, and many with OSA may be unaware of their condition. Having long-term OSA is linked to neuroinflammation caused by activated microglia in the brain, but the mechanics of this inflammation are not well understood. It is known that glucocorticoids, steroid hormones produced and released from the adrenal glands, have a suppressive effect on microglia. The purpose of this study is to explore the role that glucocorticoids have upon microglia activation induced by chronic sleep fragmentation (SF). C57BL/6J mice were …6>
Maternal Sleep Loss During Fetal Development Alters Offspring Endocrine Responses To Stress Throughout Life, Audrey Brown
Maternal Sleep Loss During Fetal Development Alters Offspring Endocrine Responses To Stress Throughout Life, Audrey Brown
Mahurin Honors College Capstone Experience/Thesis Projects
The hypothalamic-pituitary-adrenal (HPA) axis releases glucocorticoids, including corticosterone (CORT), in response to stress. CORT then negatively feeds back to inhibit its own production by binding to glucocorticoid receptors (GRs) in the hypothalamus and pituitary gland. The HPA axis is subject to “programming” by abnormal stimuli during early development, which may permanently alter how the HPA axis responds to stress. These altered responses have been linked to an increased risk for human psychiatric and metabolic disorders in later life, but the mechanism by which this happens is not fully understood. This study tests the hypothesis that changes to GR expression patterns …
Il-1Α And Tnf-Α Down-Regulate Crh Receptor-2 Mrna Expression In The Mouse Heart, Sarah C. Coste, Kurt A. Heldwein, Susan L. Stevens, Eric Tobar-Dupres, Mary P. Stenzel-Poore
Il-1Α And Tnf-Α Down-Regulate Crh Receptor-2 Mrna Expression In The Mouse Heart, Sarah C. Coste, Kurt A. Heldwein, Susan L. Stevens, Eric Tobar-Dupres, Mary P. Stenzel-Poore
Faculty Publications
Two receptors (CRH receptor type 1 and CRH receptor type 2) have been identified for the stress-induced neuropeptide, CRH and related peptides, urocortin, and urocortin II. We previously found marked down-regulation of cardiac CRH receptor type 2 expression following administration of bacterial endotoxin, lipopolysaccharide, a model of systemic immune activation, and inflammation. We postulated that inflammatory cytokines may regulate CRH receptor type 2. We show that systemic IL-1α administration significantly down-regulates CRH receptor type 2 mRNA in mouse heart. In addition, TNFα treatment also reduces CRH receptor type 2 mRNA expression, although the effect was not as marked as with …