Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Keyword
-
- Angiotensinogen (1)
- Animals (1)
- Antihypertensive Agents (1)
- Antisense oligonucleotides (1)
- Blood Pressure (1)
-
- Body mass (1)
- Cardiovascular disease (1)
- DENND5B (1)
- Disease Models, Animal (1)
- Drug Evaluation, Preclinical (1)
- Dyslipidaemias (1)
- Genetic Therapy (1)
- Humans (1)
- Hypertension (1)
- Kidney (1)
- Lipoproteins (1)
- Liver (1)
- Molecular Targeted Therapy (1)
- Obesity (1)
- Oligonucleotides, Antisense (1)
- Rats, Inbred SHR (1)
- Renin-Angiotensin System (1)
Articles 1 - 2 of 2
Full-Text Articles in Physiology
Dennd5b Regulates Intestinal Triglyceride Absorption And Body Mass, Scott M. Gordon, Edward B. Neufeld, Zhihong Yang, Milton Pryor, Lita A. Freeman, Xiao Fan, Iftikhar J. Kullo, Leslie G. Biesecker, Alan T. Remaley
Dennd5b Regulates Intestinal Triglyceride Absorption And Body Mass, Scott M. Gordon, Edward B. Neufeld, Zhihong Yang, Milton Pryor, Lita A. Freeman, Xiao Fan, Iftikhar J. Kullo, Leslie G. Biesecker, Alan T. Remaley
Saha Cardiovascular Research Center Faculty Publications
Regulation of lipid absorption by enterocytes can influence metabolic status in humans and contribute to obesity and related complications. The intracellular steps of chylomicron biogenesis and transport from the Endoplasmic Reticulum (ER) to the Golgi complex have been described, but the mechanisms for post-Golgi transport and secretion of chylomicrons have not been identified. Using a newly generated Dennd5b−/− mouse, we demonstrate an essential role for this gene in Golgi to plasma membrane transport of chylomicron secretory vesicles. In mice, loss of Dennd5b results in resistance to western diet induced obesity, changes in plasma lipids, and reduced aortic atherosclerosis. In …
Antisense Oligonucleotides Targeting Angiotensinogen: Insights From Animal Studies, Chia-Hua Wu, Ya Wang, Murong Ma, Adam E. Mullick, Rosanne M. Crooke, Mark J. Graham, Alan Daugherty, Hong S. Lu
Antisense Oligonucleotides Targeting Angiotensinogen: Insights From Animal Studies, Chia-Hua Wu, Ya Wang, Murong Ma, Adam E. Mullick, Rosanne M. Crooke, Mark J. Graham, Alan Daugherty, Hong S. Lu
Saha Cardiovascular Research Center Faculty Publications
Angiotensinogen (AGT) is the unique substrate of all angiotensin peptides. We review the recent preclinical research of AGT antisense oligonucleotides (ASOs), a rapidly evolving therapeutic approach. The scope of the research findings not only opens doors for potentially new therapeutics of hypertension and many other diseases, but also provides insights into understanding critical physiological and pathophysiological roles mediated by AGT.