Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Physiology
Mouse Strain Determines Cardiac Growth Potential, Carmen Kiper, Barry Grimes, Gary Van Zant, Jonathan Satin
Mouse Strain Determines Cardiac Growth Potential, Carmen Kiper, Barry Grimes, Gary Van Zant, Jonathan Satin
Physiology Faculty Publications
RATIONALE: The extent of heart disease varies from person to person, suggesting that genetic background is important in pathology. Genetic background is also important when selecting appropriate mouse models to study heart disease. This study examines heart growth as a function of strain, specifically C57BL/6 and DBA/2 mouse strains.
OBJECTIVE: In this study, we test the hypothesis that two strains of mice, C57BL/6 and DBA/2, will produce varying degrees of heart growth in both physiological and pathological settings.
METHODS AND RESULTS: Differences in heart dimensions are detectable by echocardiography at 8 weeks of age. Percentages of cardiac progenitor cells (c-kit+ …