Physiology Commons^™

Longitudinal Analysis Of Arterial Blood Pressure And Heart Rate Response To Acute Behavioral Stress In Rats With Type 1 Diabetes Mellitus And In Age-Matched Controls, David C. Randall, Richard O. Speakman, Dennis L. Silcox, Laura V. Brown, David R. Brown, Ming C. Gong, Abhijit R. Patwardhan, L. Raymond Reynolds, Dennis G. Karounos, Don E. Burgess, Chikodi N. Anigbogu

Physiology Faculty Publications

We recorded via telemetry the arterial blood pressure (BP) and heart rate (HR) response to classical conditioning following the spontaneous onset of autoimmune diabetes in BBDP/Wor rats vs. age-matched, diabetes-resistant control (BBDR/Wor) rats. Our purpose was to evaluate the autonomic regulatory responses to an acute stress in a diabetic state of up to 12 months duration. The stress was a 15-s pulsed tone (CS+) followed by a 0.5-s tail shock. The initial, transient increase in BP (i.e., the "first component," or C₁), known to be derived from an orienting response and produced by a sympathetic increase in peripheral …