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Activation Of Adenosine A2a But Not A2b Receptors Is Involved In Uridine Adenosine Tetraphosphate-Induced Porcine Coronary Smooth Muscle Relaxation, Changyan Sun, Tong Jiao, Daphne Merkus, Dirk J. Duncker, S. Jamal Mustafa, Zhichao Zhou
Activation Of Adenosine A2a But Not A2b Receptors Is Involved In Uridine Adenosine Tetraphosphate-Induced Porcine Coronary Smooth Muscle Relaxation, Changyan Sun, Tong Jiao, Daphne Merkus, Dirk J. Duncker, S. Jamal Mustafa, Zhichao Zhou
Faculty & Staff Scholarship
Activation of both adenosine A2A and A2B receptors (A2BR) contributes to coronary vasodilation. We previously demonstrated that uridine adenosine tetraphosphate (Up4A) is a novel vasodilator in the porcine coronary microcirculation, acting mainly on A2AR in smooth muscle cells (SMC). We further investigated whether activation of A2BR is involved in Up4A-mediated coronary SMC relaxation. Both A2AR and A2BR may stimulate H2O2 production leading to activation of KATP channels in SMCs, we also studied the involvement of H2O2 and KATP channels in Up4A-mediated effect. Coronary small arteries dissected from the apex of porcine hearts were mounted on wire myograph for Up4A concentration …