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Kisspeptin And Attributes Of Infertile Males And Females: A Cross-Sectional Study In A Subset Of Pakistani Population, Rehana Rehman, Syeda Sadia Fatima, Faiza Alam, Mussarat Ashraf, Shaheen Zafar
Kisspeptin And Attributes Of Infertile Males And Females: A Cross-Sectional Study In A Subset Of Pakistani Population, Rehana Rehman, Syeda Sadia Fatima, Faiza Alam, Mussarat Ashraf, Shaheen Zafar
Department of Biological & Biomedical Sciences
Kisspeptin, a peptide hormone, plays a pivotal role in fertility and neuroendocrine regulation of hypothalamo-pituitary-gonadal axis. Increased kisspeptin and reproductive hormones are responsible for fertility in male and females. This study aimed to explore the role of kisspeptin on hypothalamo-pituitary-gonadal axis by comparing the levels of kisspeptin in fertile and infertile subjects and identifying single nucleotide polymorphisms (SNPs) of KISS1 gene in exon 2 and exon 3 of infertile male and female cohorts. A cross-sectional study was carried out on 80 males (44 infertile and 36 fertile) and 88 females (44 in each group). Significantly high levels of kisspeptin (KP), …