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Facilitative Glucose Transporter And Its Regulation By Insulin/Igf-Like Signaling In Caenorhabditis Elegans, Shun Kitaoka
Facilitative Glucose Transporter And Its Regulation By Insulin/Igf-Like Signaling In Caenorhabditis Elegans, Shun Kitaoka
Graduate College Dissertations and Theses
In humans, the functional regulation of facilitative glucose transporters (GLUTs) by insulin plays a central role in the maintenance of glucose homeostasis. The insensitivity of tissues to this regulation results in diabetes mellitus, however, the underlying mechanisms remain largely unknown. To establish Caenorhabditis elegans (C. elegans) as a model system to study the mechanisms of insulin regulation of GLUTs because of the well-conserved insulin/IGF-like signaling (IIS) and many unique advantages of this organism, we functionally characterized 9 candidate genes of human GLUT homologues in C. elegans based on their sequence homologies to GLUTs. We found that FGT-1 is the only …