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Effects Of Leucine Supplementation And Resistance Training On Myopathy Of Diabetic Rats, Carlos Eduardo C. Martins, Vanessa B. De S. Lima, Brad J. Schoenfeld, Julio Tirapegui
Effects Of Leucine Supplementation And Resistance Training On Myopathy Of Diabetic Rats, Carlos Eduardo C. Martins, Vanessa B. De S. Lima, Brad J. Schoenfeld, Julio Tirapegui
Publications and Research
Leucine supplementation and resistance training positively influence the protein translation process and the cell signaling mTOR (mammalian target of rapamycin) pathway that regulates muscle protein balance and muscle remodeling, and thus may be therapeutic to diabetic myopathy. However, the effect of a combined intervention has not been well studied. Forty male Wistar rats were divided into five groups, control (C), diabetic control (D), diabetic + trained (DT), diabetic + L-leucine (DL), diabetic + L-leucine + trained (DLT). The supplementation of 5% leucine in chow, and resistance training were conducted for 8 weeks postweaning of rats. The extensor digitorum longus was …