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Articles 1 - 12 of 12
Full-Text Articles in Physiology
Validating A New In Vivo Model To Study Als, Izabela J. Cimachowska
Validating A New In Vivo Model To Study Als, Izabela J. Cimachowska
Student Theses and Dissertations
Buildup of oxidative stress and mitochondrial dysfunction are well known characteristics of both sporadic and hereditary amyotrophic lateral sclerosis (ALS). While both forms of the disease seem to arise from common cellular dysfunction, the genetic disease is studied to a much greater extent. Engineering novel animal models of the sporadic form of the disease is crucial for development of druggable targets to treat ALS and understand the underlying mechanisms. Interestingly, accumulation of oxidative stress by exacerbated emission of reactive oxygen species (ROS) from presynaptic mitochondria is a hallmark of both hereditary and sporadic ALS. Previous work by our laboratory showed …
Sit Less, Move More: A National Study Of Physical-Activity Behavior And Cancer, Stella O. Nwogugu
Sit Less, Move More: A National Study Of Physical-Activity Behavior And Cancer, Stella O. Nwogugu
Dissertations, Theses, and Capstone Projects
Background: Physical activity is associated with lower risks of cancer, the second leading cause of death among Americans. Yet, sedentary behavior is the prevailing lifestyle for about 80% of American adults. Additionally, cancer survivors remain significantly inactive, even though physical activity has been shown to decrease risk of cancer and cancer recurrence, improve tolerance of cancer therapy, and reduce mortality. This research explores the relative impact of personal agency, social support, and key demographic variables on physical-activity behavior for a national sample of adults as well as how these relationships differ for cancer survivors and their counterparts.
Methods: Using the …
Effects Of Chronic Stress On Safety Processing And Physiology In The Medial Prefrontal-Amygdala-Basal Forebrain Circuit, Itamar S. Grunfeld
Effects Of Chronic Stress On Safety Processing And Physiology In The Medial Prefrontal-Amygdala-Basal Forebrain Circuit, Itamar S. Grunfeld
Dissertations, Theses, and Capstone Projects
Chronic stress increases generalization of fear to non-threatening cues, a key symptom in numerous psychiatric mood disorders. However, the mechanisms through which stress impacts safety learning remain poorly understood. To probe the relationship between stress and safety learning, this dissertation employed multiple behaviors, in conjunction with in-vivo multisite physiology during explicit safety and fear discrimination learning. In Chapter 1, I outline the role of chronic stress in driving neurological adaptations that result in generalized fear and highlight how this occurs because of impaired safety cue encoding. In Chapter 2, I show that chronic stress in the form of social defeat …
Reducing Fear Overgeneralization With Safety Learning: Attention Bias As A Moderator, Boyang Fan
Reducing Fear Overgeneralization With Safety Learning: Attention Bias As A Moderator, Boyang Fan
Dissertations, Theses, and Capstone Projects
Anxiety disorders are the most prevalent mental health condition and affect one out of nine individuals around the world. Fear generalization is a neurocognitive mechanism thought to maintain and exacerbate anxiety, and thus is an important target of therapeutic interventions. Yet, intervention research and practice place relatively little emphasis on its importance. Given that a significant proportion of individuals do not respond to extant treatments of anxiety disorders, a strengthened focus on fear generalization may inform the development and personalization of new treatment approaches. Recent notions have linked fear generalization to failures in distinguishing between signals that predict the occurrence …
Regulation Of The Tubulin Homolog Ftsz In Escherichia Coli, Monika S. Buczek
Regulation Of The Tubulin Homolog Ftsz In Escherichia Coli, Monika S. Buczek
Dissertations, Theses, and Capstone Projects
Escherichia coli is a well-known pathogen, and importantly, a widely used model organism in all fields of biological sciences for cloning, protein purification, and as a model for Gram-negative bacterial species. And yet, researchers do not fully understand how this bacterium replicates and divides. Every year additional division proteins are discovered, which adds complexity to how we understand E. coli undergoes cell division. Due to their specific roles in cytokinesis, some of these proteins may be potential targets for development of antibacterials or bacteriostatics, which are much needed for fighting the current global antibacterial deficit. My thesis work focuses on …
The Vibe, Sarah P. Douglass
The Vibe, Sarah P. Douglass
Capstones
The Vibe is a long-form narrative about where tech is taking the female orgasm. The piece concludes that physiological research is a required next step when creating the climax of the future.
http://sarahpdouglass.com
The Role Of T-Box Proteins In Vertebrate Germ Layer Formation And Patterning, Sushma Teegala
The Role Of T-Box Proteins In Vertebrate Germ Layer Formation And Patterning, Sushma Teegala
Dissertations, Theses, and Capstone Projects
All of the tissues in triploblastic organisms, with the exception of the germ cells, arise from the three germ layers, ectoderm, mesoderm and the endoderm. The identification of the genes that underlie the differentiation of these layers is crucial to our understanding of development. T-box family proteins are DNA-binding transcriptional regulators that play important roles during germ layer formation in the early vertebrate embryo. Well-characterized members of this family, including the transcriptional activators Brachyury and VegT, are essential for the proper formation of mesoderm and endoderm, respectively. To date, T-box proteins have not been shown to play a role in …
Metabolic Limits And Adaptation In Humans: Daily Energy Expenditure In Race Across The Usa Athletes, Caitlin Thurber
Metabolic Limits And Adaptation In Humans: Daily Energy Expenditure In Race Across The Usa Athletes, Caitlin Thurber
Theses and Dissertations
A longitudinal doubly labeled water study of total energy expenditure (TEE) in Race Across the USA athletes, examining the effects of extremely high levels of activity on metabolic adaptation.
Total Energy Expenditure In Captive Sapajus Apella, Wren Edwards
Total Energy Expenditure In Captive Sapajus Apella, Wren Edwards
Theses and Dissertations
Primates expend approximately 50% less energy (kcal/day) for their body size than other eutherians. Using the doubly labeled water method, I investigated total energy expenditure (TEE) and physical activity in Sapajus apella. S. apella TEE was similar (p=0.67) to other platyrrhines, but 54% lower than expected for body mass.
The Role Of Perineuronal Nets In Regulating Barrel Cortex Physiology, Philip Chu
The Role Of Perineuronal Nets In Regulating Barrel Cortex Physiology, Philip Chu
Dissertations, Theses, and Capstone Projects
The ability of the brain to adapt to changing environmental conditions is regulated by genetic and environmental factors. One component of the brain extracellular matrix, a scaffold of proteins and proteoglycans, tightly ensheaths the soma and proximal processes of neurons. These Perineuronal nets (PNNs) play protective and structural roles in the brain, but also regulate plasticity and behavior. Their developmental expression is highly attenuated following sensory deprivation, or pharmacological silencing of neuronal activity. Thus, PNNs contribute to the activity dependent regulation of plasticity in the brain. Although PNNs are relatively ubiquitous in the neocortex, little is known about the degree …
The Inconstancy Of Bodies: Yvonne Meier's Works, 1985 ' 2012, Lindsey Ann Drury
The Inconstancy Of Bodies: Yvonne Meier's Works, 1985 ' 2012, Lindsey Ann Drury
Dissertations, Theses, and Capstone Projects
What is ability? And conversely, what is disability? This research on the dancer and choreographer Yvonne Meier theorizes that her more than 30-year career has challenged the oft perceived polarities between function and dysfunction, utility and futility through the physical actions of dance performances. As she developed as a dancer and choreographer, Meier engaged in forms of movement training that pledged to expand her ability by unearthing the hidden causes and effects of actions. And yet, she created works which foregrounded the very gaps in knowledge between acts, their intentions, and effects. The fundamental disability expressed through Meier's works is …
Psychological Contracts In Information Exchanges, Stanislav Mamonov
Psychological Contracts In Information Exchanges, Stanislav Mamonov
Dissertations, Theses, and Capstone Projects
Information assets continue to grow in importance of contribution to economic activity. Many emergent businesses, including Google, Amazon and Facebook, leverage crowd-sourced information assets as essential pillars supporting their business models. The appropriation of rights to information assets is commonly done through legal contracts. In practice this approach often fails to prevent conflicts between the information contributors and the companies claiming information rights. In research presented here I attempt to understand when and why the conflicts arise. I draw on psychological contract theory and I develop the framework of psychological contracts in information exchanges. I propose that intellectual property and …