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Full-Text Articles in Physiology
Apolipoprotein E4 Mediates Insulin Resistance-Associated Cerebrovascular Dysfunction And The Post-Prandial Response, Lance A. Johnson, Eileen Ruth Torres, Sydney Weber Boutros, Esha Patel, Tunde Akinyeke, Nabil J. Alkayed, Jacob Raber
Apolipoprotein E4 Mediates Insulin Resistance-Associated Cerebrovascular Dysfunction And The Post-Prandial Response, Lance A. Johnson, Eileen Ruth Torres, Sydney Weber Boutros, Esha Patel, Tunde Akinyeke, Nabil J. Alkayed, Jacob Raber
Physiology Faculty Publications
Metabolic dysfunction, commonly a result of diets high in saturated fats and sugar, is associated with impaired cognitive function and an increased risk of age-related cognitive decline (ACD) and Alzheimer’s disease (AD). Compared to the E3 isoform of apolipoprotein (apoE), the E4 isoform is a major genetic risk factor for ACD, AD, and for developing cognitive impairments following various environmental challenges, including dietary challenges such as a high-fat diet (HFD). Both insulin resistance (IR) and E4 are associated with metabolic and vascular impairments. Deficits in cerebral metabolism and cerebrovascular function have been proposed as initiating events leading to these impairments. …
Acute Exercise And Mindfulness Meditation On Learning And Memory: Randomized Controlled Intervention, Malina Austin, Paul D. Loprinzi
Acute Exercise And Mindfulness Meditation On Learning And Memory: Randomized Controlled Intervention, Malina Austin, Paul D. Loprinzi
Faculty and Student Publications
© 2019 The Author(s). Background: The purpose of this experiment was to evaluate the potential combined effects of acute exercise and mindfulness mediation on episodic memory. Methods: All data collection occurred in the authors’ laboratory (January to May of 2019). In this three-arm, within-subject design, participants (N=20; Mage=21.6 years) completed three counterbalanced laboratory visits, including Exercise Only, Exercise + Meditation and Control. Learning and memory were assessed from a word-list task. A one-factor repeated-measures ANOVA was computed for two memory outcomes, including the learning outcome (average performance across the 6 trials) and the long-term memory recall (10-minute delay). Results: The …