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Full-Text Articles in Physiology

Brain Injury And Inflammation And Placental Inflammation In Response To Repetitive Umbilical Cord Occlusions In The Near Term Ovine Fetus, Alex Xu Nov 2015

Brain Injury And Inflammation And Placental Inflammation In Response To Repetitive Umbilical Cord Occlusions In The Near Term Ovine Fetus, Alex Xu

Electronic Thesis and Dissertation Repository

We hypothesized that repetitive umbilical cord occlusions (UCOs) leading to severe acidemia will stimulate a placental and fetal inflammatory response associated with brain injury, which will be exacerbated by chronic hypoxemia and low-grade infection. Chronically instrumented fetal sheep served as controls or underwent repetitive UCOs for up to 4 hours or until fetal arterial pH was2saturation pre-UCOs of >55% and


Freeze Tolerance In The Spring Field Cricket, Gryllus Veletis, Alexander H. Mckinnon Jul 2015

Freeze Tolerance In The Spring Field Cricket, Gryllus Veletis, Alexander H. Mckinnon

Electronic Thesis and Dissertation Repository

Many insects are able to survive internal ice formation. However, the mechanisms underlying freeze tolerance are not well-understood, perhaps because of a lack of suitable model organisms. I found that the spring field cricket, Gryllus veletis, seasonally acquires freeze tolerance in the fall when kept outside in London, Ontario. Moreover, individuals acquired freeze tolerance in the laboratory in response to a simulated fall thermophotoperiod. Lab-acclimated G. veletis freeze at -6.1 ± 0.7 ºC and the acquisition of freeze tolerance is accompanied by the accumulation of proline and trehalose. Crickets survived temperatures as low as -12 ºC (1.5 h), and …