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Full-Text Articles in Physiology
Head And Neck Embryology: An Overview Of Development, Growth And Defect In The Human Fetus, Allison Baylis
Head And Neck Embryology: An Overview Of Development, Growth And Defect In The Human Fetus, Allison Baylis
Honors Scholar Theses
The purpose of this research is to explore the growth and formation of the head and neck from embryological development through puberty in order to understand how this knowledge is necessary for the development of dental and medical treatments and procedures. This is a necessary aspect of the medical and dental school curriculum at the University of Connecticut Health Center Schools of Medicine and Dental Medicine that needs to be incorporated into the current study of embryology for first-year students. Working with Dr. Christine Niekrash, D.M.D, this paper will cover the embryology and growth of the head, face and oral …
Differentiation Of Human Embryonic Stem Cell (Hesc) Derived Pyramidal Neurons, Eagan Jacqueline
Differentiation Of Human Embryonic Stem Cell (Hesc) Derived Pyramidal Neurons, Eagan Jacqueline
Honors Scholar Theses
The mammalian cerebral neocortex is a complex six-layered structure containing multiple types of neurons. Pyramidal neurons of the neocortex are formed during development in an inside-out manner, by which deep layer (DL) neurons are generated first, and upper layer (UL) neurons are generated last. Neurons within the six-layered neocortex express unique markers for their position, showing whether they are subplate, deep layer, upper layer, or Cajal-Retzius neurons. The sequential generation of cortical layers, which exists in vivo, has been partially recapitulated in vitro by differentiation of mouse embryonic stem cells (Gaspard et al., 2008) and human embryonic stem cells (hESC) …
Intrinsic Ph-Sensitivity Of Cells In The Retrotrapezoid Nucleus: Possible Role Of Glia In Respiratory Drive, Nicole Edwards
Intrinsic Ph-Sensitivity Of Cells In The Retrotrapezoid Nucleus: Possible Role Of Glia In Respiratory Drive, Nicole Edwards
Honors Scholar Theses
An increase in carbon dioxide (CO2) and protons (H+) are the primary signals for breathing. Cells that sense changes in CO2/H+ levels and increase breathing accordingly are located in a region of the caudal medulla oblongata called the retrotrapezoid nucleus (RTN). Specifically, select RTN neurons are intrinsically pH sensitive and send excitatory projections to the respiratory rhythm generator to drive breathing. Glial cells in the RTN are thought to contribute to this respiratory drive, possibly by releasing ATP in response to increases in CO2/H+ levels.
However, pH sensitivity of RTN glial cells has yet to be determined.
Therefore, the goal …