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Full-Text Articles in Physiology
Pathological Effects Of Repeated Concussive Tbi In Mouse Models: Periventricular Damage And Ventriculomegaly, Richard H. Wolferz Jr.
Pathological Effects Of Repeated Concussive Tbi In Mouse Models: Periventricular Damage And Ventriculomegaly, Richard H. Wolferz Jr.
Honors Scholar Theses
Repeated concussive traumatic brain injury (rcTBI) is the most prominent form of head injury affecting the brain, with an estimated 1.7 million Americans affected each year (Kuhn 2012). Neurologists have been concerned about the danger of repeated head impacts since the 1920’s, but researchers have only begun to understand the long-term effects of rcTBI (McKee 2009). Although symptoms can be as mild as dizziness, current research suggests that multiple concussions can lead to a progressive degenerative brain disease known as chronic traumatic encephalopathy (CTE) (Luo 2008, McKee 2009, Kane 2013). Research on the brain is just beginning to scratch the …
Temporal Localization Of Insulin-Like Growth Factor 1 (Igf1) Positive Cells In Developing Hypothyroid Brain, Shelby Anne Kline
Temporal Localization Of Insulin-Like Growth Factor 1 (Igf1) Positive Cells In Developing Hypothyroid Brain, Shelby Anne Kline
All Graduate Theses, Dissertations, and Other Capstone Projects
Hypothyroidism has been known to result in numerous neuroanatomical defects in the developing brain. To investigate further into the mechanism in which these defects are obtained, local brain insulin-like growth factor 1 (Igf1) was investigated in relation to the hypothyroid brain. There are many similarities between hypothyroidism and the Igf1 deficient brain. Additionally, TH (thyroid hormone) is known to interact with Igf1. Therefore, the purpose of this study was to investigate the effect of induced congenital hypothyroidism on the temporal expression of Igf1-positive cells in the brain. To investigate the relationship between TH and Igf1 in the brain, we inhibited …