Physiology Commons^™

Preparing For A National Weightlifting Championships: A Case Series, S. Kyle Travis, Satoshi Mizuguchi, Michael H. Stone, William A. Sands, Caleb D. Bazyler

Caleb D. Bazyler

INTRODUCTION: Monitoring an athlete’s psychological, physiological, and performance level is important when preparing for a major competition. No study to date has tracked a high-level weightlifter peaking for a major competition all the way up to the day of competition. Assessing performance at a competition is vital to ascertain if the athlete has reached a peaked and if peak performance will actually be expressed during the competition. PURPOSE: Therefore, the purpose of this study was to determine when peak jumping performance was achieved and whether psychological or physiological variables explained any jump performance changes in a high-level female weightlifter preparing …

Microrna Cargo Of Extracellular Vesicles From Alcohol-Exposed Monocytes Signals Naive Monocytes To Differentiate Into M2 Macrophages, Banishree Saha, Fatemeh Momen-Heravi, Karen Kodys, Gyongyi Szabo

Gyongyi Szabo

Membrane-coated extracellular vesicles (EVs) released by cells can serve as vehicles for delivery of biological materials and signals. Recently, we demonstrated that alcohol-treated hepatocytes cross-talk with immune cells via exosomes containing microRNA (miRNAs). Here, we hypothesized that alcohol-exposed monocytes can communicate with naive monocytes via EVs. We observed increased numbers of EVs, mostly exosomes, secreted by primary human monocytes and THP-1 monocytic cells in the presence of alcohol in a concentration- and time-dependent manner. EVs derived from alcohol-treated monocytes stimulated naive monocytes to polarize into M2 macrophages as indicated by increased surface expression of CD68 (macrophage marker), M2 markers (CD206 …

Outcomes Of Early Versus Late Nephrology Referral In Chronic Kidney Disease – A Systematic Review, Neil A. Smart Assoc. Prof.

Neil Smart

Background As late provision of specialist care, prior to starting dialysis therapy, is believed to be associated with increased morbidity and mortality, a systematic review was undertaken to evaluate clinical outcomes relating to early versus late referral of patients to nephrology services.

Methods: Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE and EMBASE were searched up until September 2008 for studies of early versus late nephrology referral in adult (>18 years) patients with chronic kidney disease. Early referral was defined by the time period, at which patients were referred to a nephrologist.

Findings: No randomized, controlled trials were found. …