Physiology Commons^™

Impaired Hydrogen Sulfide Protein Expression In Patients With Peripheral Artery Disease, Dong Gun Jin, Kollyn B. Jallen, Liz Pekas, Song-Young Park

UNO Student Research and Creative Activity Fair

INTRODUCTION: Hydrogen sulfide (H₂S) is a gaseous signaling molecule that serves various roles in the vasculature, such as upregulating angiogenesis, vascular smooth muscle relaxation, protecting endothelial function, and regulating redox balance. Despite H₂S’s positive impacts on vascular homeostasis, it is important to note that its actions depend on its concentrations. At high concentrations, H₂S has been reported to increase oxidative stress damage, such as oxidation of cysteine residues and lipid peroxidation. This may indicate that H₂S may act as a ‘double-edged sword’ in the field of vascular physiology. Peripheral artery disease (PAD) …