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Regulation Of Thyroid Hormone-Induced Development In Vivo By Thyroid Hormone Transporters And Cytosolic Binding Proteins, Jinyoung Choi, Christine L. Moskalik, Allison Ng, Stephen F. Matter, Daniel R. Buchholz

Publications & Research

Differential tissue sensitivity/responsivity to hormones can explain developmental asynchrony among hormone-dependent events despite equivalent exposure of each tissue to circulating hormone levels. A dramatic vertebrate example is during frog metamorphosis, where transformation of the hind limb, brain, intestine, liver, and tail are completely dependent on thyroid hormone (TH) but occurs asynchronously during development. TH transporters (THTs) and cytosolic TH binding proteins (CTHBPs) have been proposed to affect the timing of tissue transformation based on expression profiles and in vitro studies, but they have not been previously tested in vivo. We used a combination of expression pattern, relative expression level, …