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Regulation Of Endothelial Nitric Oxide Synthase In Pulmonary Myofibroblasts, Jonathan David Faughn
Regulation Of Endothelial Nitric Oxide Synthase In Pulmonary Myofibroblasts, Jonathan David Faughn
Masters Theses & Specialist Projects
Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease leading to decreased lung volume and eventual respiratory failure. At present, the median post-diagnosis lifespan is between three and six years. Myofibroblasts are collagen-secreting cells essential for wound healing, but also implicated in the fibroproliferation and extra cellular matrix deposition commonly seen in IPF. The nitric oxide (NO) signaling pathway is implicated in protomyofibroblast to myofibroblast transition and regulation. Previous work has shown that in pulmonary myofibroblasts, endothelial nitric oxide synthase (eNOS) is the primary NOS isoform expressed. The current study used cultured rat pulmonary myofibroblasts between passages two and five …