Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Physiology
S-Nitrosylation Suppresses Stromal Interaction Molecule-1 Activation And Ameliorates Cardiomyocyte Hypertrophy, Jinhui Zhu
Electronic Thesis and Dissertation Repository
Stromal interaction molecule 1 (STIM1) is an endo/sarcoplasmic reticulum (ER/SR) calcium (Ca2+) sensor that activates store-operated Ca2+ entry (SOCE) following Ca2+ depletion. SOCE-induced elevation of cytosolic Ca2+ stimulates the calcineurin/nuclear factor of activated T cells (NFAT) pathway, which upregulates pro-hypertrophic gene transcription. Nitric oxide (NO) regulates protein functions by S-nitrosylation, but how NO regulates SOCE in inhibiting cardiac hypertrophy is unclear. I hypothesize that NO stabilizes and inhibits STIM1 via S-nitrosylation and mitigates cardiomyocyte hypertrophy. STIM1 residues Cys49 and Cys56 were susceptible to S-nitrosylation by S-nitrosoglutathione (GSNO) and sodium nitroprusside (SNP), …