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Articles 1 - 2 of 2
Full-Text Articles in Physiology
Dirigent Domain-Containing Protein Is Part Of The Machinery Required For Formation Of The Lignin-Based Casparian Strip In The Root, Prashant S. Hosmani, Takehiro Kamiya, John Danku, Sadaf Naseer, Niko Geldner, Mary Lou Guerinot, David Salt
Dirigent Domain-Containing Protein Is Part Of The Machinery Required For Formation Of The Lignin-Based Casparian Strip In The Root, Prashant S. Hosmani, Takehiro Kamiya, John Danku, Sadaf Naseer, Niko Geldner, Mary Lou Guerinot, David Salt
Dartmouth Scholarship
The endodermis acts as a "second skin" in plant roots by providing the cellular control necessary for the selective entry of water and solutes into the vascular system. To enable such control, Casparian strips span the cell wall of adjacent endodermal cells to form a tight junction that blocks extracellular diffusion across the endodermis. This junction is composed of lignin that is polymerized by oxidative coupling of monolignols through the action of a NADPH oxidase and peroxidases. Casparian strip domain proteins (CASPs) correctly position this biosynthetic machinery by forming a protein scaffold in the plasma membrane at the site where …
Modeling The Influence Of Vitamin D Deficiency On Cigarette Smoke-Induced Emphysema, Mardi A. Crane-Godreau, Candice C. Black, Andrew J. Giustini, Tenzin Dechen, Jihan Ryu, James A. Jukosky, Hong-Kee Lee, Katherine Bessette, Nora R. Ratcliffe, P. Jack Hoopes, Steven Fiering, John A. Kelly, J. C. Leiter
Modeling The Influence Of Vitamin D Deficiency On Cigarette Smoke-Induced Emphysema, Mardi A. Crane-Godreau, Candice C. Black, Andrew J. Giustini, Tenzin Dechen, Jihan Ryu, James A. Jukosky, Hong-Kee Lee, Katherine Bessette, Nora R. Ratcliffe, P. Jack Hoopes, Steven Fiering, John A. Kelly, J. C. Leiter
Dartmouth Scholarship
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. While the primary risk factor for COPD is cigarette smoke exposure, vitamin D deficiency has been epidemiologically implicated as a factor in the progressive development of COPD-associated emphysema. Because of difficulties inherent to studies involving multiple risk factors in the progression of COPD in humans, we developed a murine model in which to study the separate and combined effects of vitamin D deficiency and cigarette smoke exposure. During a 16-week period, mice were exposed to one of four conditions, control diet breathing room air (CD-NS), control …