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Full-Text Articles in Physiology
Protective Effects Of The Novel Phytonutrient Spectra7 Against Intestinal Tight Junction Disruption: Composition Matters, Erin Olson
Honors Program Projects
The prevalence of intestinal inflammatory diseases is increasing, and pharmacologic agents for intervention are currently limited. Preserving epithelial tight junction (TJ) integrity and preventing underlying immune cell activation by intestinal bacteria are key targets for abrogating the perpetual inflammatory cycle that plagues these diseases. Phytonutrients have shown promise for their ability to reduce cellular inflammation, but the extent of their efficacy in an intestinal model of inflammation is not well understood. Here, we hypothesized that S7, a novel phytonutrient derived from extracts rich in curcuminoids and catechins, would reduce immune cell inflammation and preserve TJ integrity in an in vitro …
Locating The Modifier Of Segregation Distorter In Drosophila Melanogaster, Samuel Craven
Locating The Modifier Of Segregation Distorter In Drosophila Melanogaster, Samuel Craven
Honors Program Projects
The Drosophila melanogaster meiotic drive system Segregation Distorter (SD) has been a topic of great interest over the past decades due to its implications for fertility issues in fruit flies and other species as well. Several genes have been associated with this system; however, little research has focused on a particular one of these genes—the Modifier of SD. The location of this modifier gene is still unknown, so multiple deleted segments of DNA that compose a suspect area along the 2nd chromosome were tested here to see if some level of distortion is established in the absence of these segments. …