Physiology Commons^™

Serum Amyloid A Binds To Gibrin(Ogen), Promoting Fibrin Amyloid Formation, Martin J. Page, Greig J. A. Thomson, J. Massimo Nunes, Anna-Mart Engelbrecht, Theo A. Nell, Willem J. S. De Villiers, Maria C. De Beer, Lize Engelbrecht, Douglas B. Kell, Etheresia Pretorius

Physiology Faculty Publications

Complex associations exist between inflammation and thrombosis, with the inflammatory state tending to promote coagulation. Fibrinogen, an acute phase protein, has been shown to interact with the amyloidogenic ß-amyloid protein of Alzheimer’s disease. However, little is known about the association between fibrinogen and serum amyloid A (SAA), a highly fibrillogenic protein that is one of the most dramatically changing acute phase reactants in the circulation. To study the role of SAA in coagulation and thrombosis, in vitro experiments were performed where purified human SAA, in concentrations resembling a modest acute phase response, was added to platelet-poor plasma (PPP) and whole …