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Full-Text Articles in Physiology
The Role Of Creg1 As A Master Regulator Of Liver Function, Abdulrahman Siran Aldaghmi
The Role Of Creg1 As A Master Regulator Of Liver Function, Abdulrahman Siran Aldaghmi
Masters Theses
The liver is known as the chemical factory of the body because it performs a wide range of biochemical functions required for life. Since the liver has such an important role in regulation of normal physiological processes, liver diseases cause a high rate of morbidity and mortality. Therefore, understanding the mechanisms of liver development will shed light on the causes of liver disease. In this study, a cell line model that utilizes rat hepatoma cells (Fg14) and hepatoma variant cells (H11) was used to identify master regulators of liver gene expression. Whole genome expression studies identified the gene CREG1 (Cellular …
Metabolic And Morphologic Shifts In Neuro2a Cells Cultured In Galactose Medium, Leah Welker
Metabolic And Morphologic Shifts In Neuro2a Cells Cultured In Galactose Medium, Leah Welker
Masters Theses
It has been observed that highly-proliferating cells, such as cancer cells, rely mainly on glycolysis for ATP production, regardless of presence of oxygen. This effect, however, can be reversed by changing the main energy substrate in the medium from glucose to galactose. The oxidation of galactose in glycolysis yields less net ATP, presumably forcing the cell into OXPHOS. This has been established in many cell lines, including HeLA, HepG2, and skeletal muscle cells. As of yet, this has not been reproduced in neuronal cells. Using Neuro2a, a murine neuroblastoma cell line, this study exposes neuronal cells to galactose medium, and …