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Full-Text Articles in Physiology
Prostate Field Cancerization -- Thinking Outside The Tumor, Dor Shoshan, Marco Bisoffi
Prostate Field Cancerization -- Thinking Outside The Tumor, Dor Shoshan, Marco Bisoffi
Student Scholar Symposium Abstracts and Posters
Prostate field cancerization (or field effect) is characterized by the presence of molecular alterations in histologically normal tissues adjacent to adenocarcinomas. Accordingly, our research indicates deregulated expression of several proteins that define this type of molecular pathology. The scope of the present study was to determine the expression of the key transcription factor and potential marker of field cancerization early growth response 1 (EGR-1) in human prostate tissues derived from prostatectomies and biopsy cores.
EGR-1 was detected by immunofluorescence using a polyclonal anti-human EGR-1 and Alexa Fluor 488-conjugated secondary antibodies. EGR-1 expression was quantitated by determining the pixel count per …