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Full-Text Articles in Other Pharmacology, Toxicology and Environmental Health
Evaluating The Cytotoxic Effects Of Cellulose Nanocrystals (Cncs) Using Autobioluminescent Yeast And Human Cells, Julianna Hughes Burchett
Evaluating The Cytotoxic Effects Of Cellulose Nanocrystals (Cncs) Using Autobioluminescent Yeast And Human Cells, Julianna Hughes Burchett
EURēCA: Exhibition of Undergraduate Research and Creative Achievement
Cellulose nanocrystals (CNCs) are widely used in different industries including pharmaceutical and cosmetic production due to their adept physical and biological properties. Because CNCs are becoming a more prevalent material and have a high potential of being redistributed in the environment, it is important to understand their toxic potentials in biological systems, including organisms of various trophic levels. This study evaluated the cytotoxic effects of CNCs in the lower eukaryotic organism Saccharomyces cerevisiae and human embryonic kidney (HEK293) cells using autobioluminescent yeast and human cell reporters, respectively. The S. cerevisiae and HEK293 reporter cells were engineered to express a synthetic …
The Influence Of Abiotic Factors On The Uptake And Elimination Of 3-Trifluoromethyl-4-Nitrophenol By Larval Sea Lamprey (Petromyzon Marinus), Benjamin Livingston Hlina
The Influence Of Abiotic Factors On The Uptake And Elimination Of 3-Trifluoromethyl-4-Nitrophenol By Larval Sea Lamprey (Petromyzon Marinus), Benjamin Livingston Hlina
Theses and Dissertations (Comprehensive)
The backbone of sea lamprey (Petromyzon marinus) control in the Great Lakes is the use of the piscicide, 3-trifluoromethyl-4-nitrophenol (TFM), which is applied to streams containing larval sea lampreys. However, TFM effectiveness can be influenced by abiotic factors such as pH and temperature, which fluctuate daily and seasonally. The objectives of this thesis were to evaluate the influence of pH, temperature, and season on the toxicity, uptake, and elimination of TFM by larval sea lamprey. Radio-labeled TFM (14C-TFM) was used to determine how TFM uptake rates varied at different water pHs or temperatures during exposure to …
The Sublethal Physiological Effects Of Exposure To Copper And Silver Mixtures On Rainbow Trout (Oncorhynchus Mykiss), Wesley Truong
The Sublethal Physiological Effects Of Exposure To Copper And Silver Mixtures On Rainbow Trout (Oncorhynchus Mykiss), Wesley Truong
Theses and Dissertations (Comprehensive)
The mechanisms behind metal-metal interactions in freshwater environments are currently not well understood. Freshwater environments consist of many different types of metals, from those naturally present such as copper (Cu) and those that originate from anthropogenic sources like silver (Ag). Both Cu and Ag use apical sodium (Na+) channels for uptake into the gills of freshwater fish. In the gills, the mechanisms of Cu2+ and Ag+ toxicity appear to be similar to one another, which is by inhibiting Na+ /potassium (K+)- adenosine triphosphatase (NKA) and carbonic anhydrase (CA). Inhibition of NKA and CA …