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Full-Text Articles in Pharmacology, Toxicology and Environmental Health
Does Bisphenol A Induce Superfeminization In Marisa Cornuarietis? Part I: Intra- And Inter-Laboratory Variability In Test Endpoints, Valery E. Forbes, Henriette Selck, Annemette Palmqvist, John Aufderheide, Ryan Warbritton, Nadine Pounds, Roy Thompson, Norbert Caspers
Does Bisphenol A Induce Superfeminization In Marisa Cornuarietis? Part I: Intra- And Inter-Laboratory Variability In Test Endpoints, Valery E. Forbes, Henriette Selck, Annemette Palmqvist, John Aufderheide, Ryan Warbritton, Nadine Pounds, Roy Thompson, Norbert Caspers
Valery Forbes Publications
It has been claimed that bisphenol A (BPA) induces superfeminization in the freshwater gastropod, Marisa cornuarietis. To explore the reproducibility of prior work, here we present results from a three-laboratory study, the objectives of which were to determine the mean and variability in test endpoints (i.e., adult fecundity, egg hatchability, and juvenile growth) under baseline conditions and to identify the sources of variability. A major source of variability for all of the measured endpoints was due to differences within and among individuals. With few exceptions, variability among laboratories and among replicate tanks within laboratories contributed little to the observed variability …
Does Bisphenol A Induce Superfeminization In Marisa Cornuarietis? Part Ii: Toxicity Test Results And Requirements For Statistical Power Analyses, Valery E. Forbes, John Aufderheide, Ryan Warbritton, Nelly Van Der Hoeven, Norbert Caspers
Does Bisphenol A Induce Superfeminization In Marisa Cornuarietis? Part Ii: Toxicity Test Results And Requirements For Statistical Power Analyses, Valery E. Forbes, John Aufderheide, Ryan Warbritton, Nelly Van Der Hoeven, Norbert Caspers
Valery Forbes Publications
This study presents results of the effects of bisphenol A (BPA) on adult egg production, egg hatchability, egg development rates and juvenile growth rates in the freshwater gastropod, Marisa cornuarietis. We observed no adult mortality, substantial inter-snail variability in reproductive output, and no effects of BPA on reproduction during 12 weeks of exposure to 0, 0.1, 1.0, 16, 160 or 640 μg/L BPA. We observed no effects of BPA on egg hatchability or timing of egg hatching. Juveniles showed good growth in the control and all treatments, and there were no significant effects of BPA on this endpoint. Our …