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Articles 1 - 3 of 3
Full-Text Articles in Pharmacology, Toxicology and Environmental Health
The Role Of Oatp-Mediated Statin Transport In Pancreatic Beta Cell Function, Michelle S. Kim
The Role Of Oatp-Mediated Statin Transport In Pancreatic Beta Cell Function, Michelle S. Kim
Electronic Thesis and Dissertation Repository
Cholesterol-lowering statins, or the 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors, are one of the leading treatments for hypercholesterolemia and are recognized for their ability to prevent cardiovascular events. Though safe and effective for most, statin therapy has recently been associated with new-onset diabetes, with risk varying depending on potency and dose. Additionally, in vitro data suggest statin-mediated alterations in insulin secretion; however, the exact mechanism is currently unknown. Statins are known substrates of various membrane transporters belonging to the organic anion-transporting polypeptides (OATPs), on which they rely heavily for hepatic uptake and therapeutic efficacy. We have recently reported expression of OATP1B3 …
The Effects Of Acetylenic Tricyclic Bis-(Cyano Enone) On Cell Migration, Eddie Chan
The Effects Of Acetylenic Tricyclic Bis-(Cyano Enone) On Cell Migration, Eddie Chan
Electronic Thesis and Dissertation Repository
Although cancer survival rates have significantly improved over the past few decades, the improvements are primarily due to early diagnosis and inhibiting cancer growth. Limited progress has been made in the treatment of cancer metastasis, which contributes to 90% of cancer related deaths, and therapeutic agents targeting the various aspects of metastasis are lacking. One potential approach is to utilize small pharmacological compounds to inhibit tumour cell motility, as a strategy against tumour cell migration, invasion, and metastasis. The acetylenic tricyclic bis-(cyano enone), TBE-31, has been shown to be a promising chemopreventative compound. However, its effects on cell migration are …
Microbial Repopulation Following In Situ Star Remediation, Gavin Overbeeke
Microbial Repopulation Following In Situ Star Remediation, Gavin Overbeeke
Electronic Thesis and Dissertation Repository
In situ STAR (Self-sustaining Treatment for Active Remediation) is an emerging remediation technology which uses smouldering combustion to destroy nonaqueous phase liquid (NAPL) contamination in the subsurface. Since STAR smouldering travels through contaminated soils slowly (~0.5 to 5 m/day) and subjects them to high temperatures (400–1000°C), it is expected that this technology will thoroughly dry and sterilize the zones which it treats. Further, soils surrounding the treatment zone which are not smouldered will be heated, although not smouldered, by virtue of their proximity to STAR, impacting microbial communities within them. Therefore, the objectives of this work are to quantify the …