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Kinetics And Passive Protection Efficacy Induced By Purified Ava Human Immunoglobulin G In Rabbits Against A Bacillus Anthracis Aerosol Challenge, Jennifer Lee Plahovinsak
Kinetics And Passive Protection Efficacy Induced By Purified Ava Human Immunoglobulin G In Rabbits Against A Bacillus Anthracis Aerosol Challenge, Jennifer Lee Plahovinsak
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The present study was conducted to determine the half-life, assess the toxicity, and passive protection efficacy of purified immunoglobulin G (IgG) from Anthrax Vaccine Adsorbed (AVA) vaccinated human donors. Half-life determinations were calculated from the reportable values obtained using the anti-PA ELISA assay and the Centers for Disease Control's (CDC) "ELISA for Windows" software. For toxicity evaluations animals were observed clinical for one hour post administration and for 14-days post-treatment. The protection efficacy was determined based upon the mortality results from a lethal Bacillus anthracis aerosol challenge. While no protection was achieved in this delayed exposure scenario, the study yielded …