Open Access. Powered by Scholars. Published by Universities.®
Pharmacology, Toxicology and Environmental Health Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Engineering (3)
- Environmental Health (3)
- Chemicals and Drugs (2)
- Medicine and Health Sciences (2)
- Agricultural Science (1)
-
- Agronomy and Crop Sciences (1)
- Biomedical Engineering and Bioengineering (1)
- Chemical Engineering (1)
- Chemistry (1)
- Civil Engineering (1)
- Civil and Environmental Engineering (1)
- Earth Sciences (1)
- Environmental Chemistry (1)
- Environmental Engineering (1)
- Food Biotechnology (1)
- Food Science (1)
- Hydraulic Engineering (1)
- Medicinal Chemistry and Pharmaceutics (1)
- Molecular, Cellular, and Tissue Engineering (1)
- Other Chemicals and Drugs (1)
- Other Pharmacology, Toxicology and Environmental Health (1)
- Pharmacology (1)
- Physical Sciences and Mathematics (1)
- Plant Sciences (1)
- Soil Science (1)
- Toxicology (1)
- Keyword
-
- Antibiotics (1)
- Bioavailability (1)
- Boundary layers (1)
- Cation exchange capacity (1)
- Cation sorption (1)
-
- Crystal (1)
- Crystal growth (1)
- Developmental toxicology (1)
- Diffusion (1)
- Felodipine (1)
- Freundlich sorption model (1)
- In vitro (1)
- Inhibition of crystal growth (1)
- Integration (1)
- Lakes (1)
- Macrolides (1)
- Mass transfer limited (1)
- Nanocrystal (1)
- Oligomer (1)
- Paclitaxel (1)
- RDA (1)
- Roatating disk apparatus (1)
- Stratified (1)
- Turbulence (1)
- Type I collagen (1)
- Vasculogenesis (1)
- Vertical mixing (1)
Articles 1 - 7 of 7
Full-Text Articles in Pharmacology, Toxicology and Environmental Health
Co-Crystallization Of Urea Granules For Slower Dissolution, Vidya Nagaraju, Carl Wassgren, Kingsly Ambrose
Co-Crystallization Of Urea Granules For Slower Dissolution, Vidya Nagaraju, Carl Wassgren, Kingsly Ambrose
Graduate Industrial Research Symposium
Co-crystals are multicomponent crystals formed through hydrogen bond interactions. Co-crystallization, the process of developing cocrystals, serves as a versatile approach for discovering new solid forms of active ingredients (AIs) that can alter physical properties such as solubility, dissolution rates, and stability. These co-crystals can be produced through three main methods: solid-state methods, solution-based methods, and supercritical fluid methods. Recently, the solid-state (mechanochemical) method of developing cocrystals has gained more attention from researchers in the development of slow-release urea fertilizers. This technique can also be applied to the development of urease inhibitors. These multicomponent crystals present a potential solution to the …
Nucleic Acid Detection Of Live Pathogens On Contaminated Foods, Simerdeep Kaur, Mohit Verma
Nucleic Acid Detection Of Live Pathogens On Contaminated Foods, Simerdeep Kaur, Mohit Verma
Graduate Industrial Research Symposium
The goal is to develop a point-of-care biosensor for the detection of live pathogens contaminating beef products. Biosensing of live pathogens is based on isothermal amplification of nucleic acid on a paper-based device. A colorimetric dye is employed as an indicator of the amplification product for visual result. The assay incorporates a compound Propidium monoazide (PMA) that makes the DNA from dead cells inaccessible for amplification. This approach is especially applicable for pathogens that can enter a viable but non-culturable state (VBNC).
Full-Water Column Turbulence Parameterization Of Stratified Waters In Southern Lake Michigan, Kyla A. Prendergast, Cary D. Troy, David Cannon
Full-Water Column Turbulence Parameterization Of Stratified Waters In Southern Lake Michigan, Kyla A. Prendergast, Cary D. Troy, David Cannon
The Summer Undergraduate Research Fellowship (SURF) Symposium
Full water column mean flow and turbulence structure was characterized at two stratified locations in Lake Michigan (a. Muskegon, MI; b. Michigan City, IN) in order to better understand the filtration potential of invasive quagga mussels. Invasive quagga mussels in Lake Michigan are filter feeders and can dramatically alter clarity as well as the biological/chemical characteristics of the water column. This filtering capacity is highly contingent on turbulence characteristics throughout the water column, which is poorly understood in the Great Lakes. Using velocity, temperature, and turbulence data collected from these locations, the structure of the water column turbulence was modeled …
Mobility Characteristics Of Azithromycin In Soil, Ryan Minter, Jihyun Kim, Linda Lee
Mobility Characteristics Of Azithromycin In Soil, Ryan Minter, Jihyun Kim, Linda Lee
The Summer Undergraduate Research Fellowship (SURF) Symposium
The presence of pharmaceutical and personal care products (PPCPs) in the environment has become a widespread problem in recent decades. Azithromycin, a macrolide antibiotic commonly prescribed for infections in humans, has been detected in waste treatment plant discharge and surface waters across the world. Data on the mobility characteristics of azithromycin in soil is scarce, and further studies must be performed to explore the potential for azithromycin leaching to groundwater or becoming available for plant uptake. In this study, azithromycin sorption isotherms were measured on eight soils varying in pH, organic carbon content, and clay content. Soil was equilibrated with …
Macrophage Uptake And Cytotoxicity Of Paclitaxel Nanocrystals, Deborah Lee, Emeri Zhang, Wei Gao, Tonglei Li
Macrophage Uptake And Cytotoxicity Of Paclitaxel Nanocrystals, Deborah Lee, Emeri Zhang, Wei Gao, Tonglei Li
The Summer Undergraduate Research Fellowship (SURF) Symposium
Effective drug delivery remains one of the most challenging tasks in combatting cancer cells. Anti-cancer drugs such as Paclitaxel (PTX) often struggle in having a high drug effect because they are often phagocytized by macrophages in Reticuloendothelial System (RES) before reaching the cancer cells. To combat this problem, PTX was inserted in a nanocrystal, coated with non-ionic surfactant F68; it is speculated that this formulation will minimize the particle aggregation and decrease the cellular uptake in the RES, which will increase the overall efficacy of the drug in the target areas. The aim of this project was to compare the …
Tissue Engineering: Applications In Developmental Toxicology, Stephanie N. Thiede, Nimisha Bajaj, Kevin Buno, Sherry L. Voytik-Harbin
Tissue Engineering: Applications In Developmental Toxicology, Stephanie N. Thiede, Nimisha Bajaj, Kevin Buno, Sherry L. Voytik-Harbin
The Summer Undergraduate Research Fellowship (SURF) Symposium
In vivo toxicology assays are expensive, low-throughput, and often not predictive of a human response. Three-dimensional in vitro human cell-based tissue systems incorporating cell-cell and cell-matrix interactions have promise to provide high-throughput, physiologically-relevant information on the mechanism of the toxin and a more accurate assessment of the toxicity of a chemical before progression to human trials. Quantification of the disruption of vasculogenesis, the de novo formation of blood vessels from endothelial progenitor cells, can serve as an appropriate indicator of developmental toxicity since vasculogenesis is critical to the early development of the circulatory system. The current routinely used in vitro …
Non-Mass Transfer Limited Crystal Growth, Ryan J. Smyth, Caitlin Schram, Stephen P. Beaudoin
Non-Mass Transfer Limited Crystal Growth, Ryan J. Smyth, Caitlin Schram, Stephen P. Beaudoin
The Summer Undergraduate Research Fellowship (SURF) Symposium
There are many different active pharmaceutical ingredients (APIs) that have been discovered in research labs all around the world that can be used to treat and cure patients with a variety of different ailments. The challenge with these APIs in treatments is that they are not soluble in water, thus they low absorption into the blood stream (bio-availability). The key to making these APIs more bio-available is to understand how they grow as crystals and drop out of the aqueous solutions. One of the ways these APIs were made more bio-available is to render them amorphous and suspend them in …