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Full-Text Articles in Pharmacology, Toxicology and Environmental Health
Effects Of Ammonium Perchlorate On The Thyroid Hormone Levels Of The Sprague-Dawley Rat, James H. King Jr.
Effects Of Ammonium Perchlorate On The Thyroid Hormone Levels Of The Sprague-Dawley Rat, James H. King Jr.
Theses and Dissertations
The purpose of this research was to determine the threshold dose for ammonium perchlorate (AP) in the Sprague-Dawley rat. No dose response data exist for AP and the EPA has studied literature on the subject of perchlorates to determine a provisional reference dose. The Perchiorate Group, a consortium of DoD and industry representatives, believes this provisional reference dose is too conservative. This experiment was executed to provide dose response data on which to base a more accurate reference dose. The study consisted of eight groups of 12 Sprague-Dawley rats, six male and six female, which were exposed to incremental doses …
Physiologically-Based Pharmacokinetic Modeling Of Skin Absorption Using Dermal Subcompartments, Richard L. Bookout Jr.
Physiologically-Based Pharmacokinetic Modeling Of Skin Absorption Using Dermal Subcompartments, Richard L. Bookout Jr.
Theses and Dissertations
Dermal penetration of chemicals and drugs is important to both toxicologists and pharmacologists. Drug developers try to enhance and environmental professionals try to limit penetration of chemicals through the skin. Both can use predictive biologically-based mathematical models to assist in understanding the processes involved. When these models are based on physiological and biochemical parameters which can be measured in the laboratory, they can be extremely useful. Appropriately validated models based on first principles can be predictive of human exposures when the processes involved are adequately understood. In this thesis we develop four new physiologically-based pharmacokinetic (PBPK) models to predict blood …