Pharmacology, Toxicology and Environmental Health Commons^™

Pesticide Use On Broccoli, Cabbage, Cauliflower And Peppers Grown In Connecticut: 1991, James J. Turner Ii, Candace L. Bartholomew

Storrs Agricultural Experiment Station

No abstract provided.

Book Review, Allan M. Soobert

RISK: Health, Safety & Environment (1990-2002)

Review of: VALERIE M. FOGLEMAN, HAZARDOUS WASTE CLEANUP, LIABILITY AND LITIGATION: A COMPREHENSIVE GUIDE TO SUPERFUND LAW. (Quorum Books 1992) [320 pp.] Acronyms, index, preface, selected bibliography. LC 91-47999, ISBN 0-89930-647-0. [$59.95 cloth. 88 Post Road West; Westport CT 06881.)

Pesticide Use On Peaches And Pears Grown In Connecticut: 1991, James L. Turner Ii, Candace L. Bartholomew

Storrs Agricultural Experiment Station

No abstract provided.

Toxics Use Reduction: Pro And Con, Francine Laden, George M. Gray

RISK: Health, Safety & Environment (1990-2002)

With the Massachusetts Toxics Use Reduction Act as an example, important issues related to the goals and effectiveness of TUR are examined. The benefits as claimed by proponents are contrasted with shortcomings outlined by opponents in point-counterpoint style. Ultimately, the authors call for more balanced analysis.

Book Review, James R. Baum

RISK: Health, Safety & Environment (1990-2002)

Review of: MANAGEMENT OF HAZARDOUS AGENTS. Vol. 1: INDUSTRIAL AND REGULATORY APPROACHES. Vol. 2: SOCIAL, POLITICAL, AND POLICY ASPECTS. (Duane G. LeVine & Arthur C. Upton eds., Praeger 1992). Each volume contains: bibliography, series foreword, foreword, figures, notes, biographical references, tables, index. Vol. 1: [194 pp.] LC-92-167 ISBN 0-275-94322-4. Vol. 2: [188 pp.] ISBN 0-275-94323-2. [Cloth, each $49.95. 88 Post Road West; Westport CT 06881.]

Interim Report On Data And Methods For Assessment Of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin Risks To Aquatic Life And Associated Wildlife, Steven P. Bradbury, Philip M. Cook, Russell J. Erickson, Robert L. Spehar, Gerald T. Ankney

Steven P. Bradbury

In April, 1991 the Administrator of the U.S. Environmental Protection Agency (EPA) announced that the Agency would conduct a scientific reassessment of the risk of 2,3,7,8-tetrachlorodibenzo-p-dioxin (hereafter referred to as TCDD), and similar chemicals, to human health and the environment. Since 1985, EPA has classified TCDD, which it considers the most potent known animal carcinogen, as a probable human carcinogen. Sources of TCDD in the environment were subsequently regulated on the basis of animal cancer rates extrapolated to doses associated with human exposures. Recently, consensus has developed that the toxic effects of TCDD appear to be mediated by its binding …

Connecticut River 2020 Project: Cost And Economic Impact Analysis, Center For Economic Development

Center for Economic Development Technical Reports

This project addresses the following issues:

1) Analysis of the cost of abating water pollution sources contaminating the Lower Connecticut River for the communities of Agawam, Chicopee, Holyoke, Ludlow, South Hadley, Springfield, and West Springfield.

2) Analysis of the impact of water pollution abatement measures on the economy of Hamden and Hampshire Counties.

3) Analysis of the impact of additional economic development on Hamden and Hampshire Counties resulting from an improved river resource.

4) Assessment and analysis of increased recreational activities resulting from a cleaner river resource.

The research was conducted by the Center for Economic Development at the University …

Toxicokinetics And Metabolism Of Aniline And 4-Chloroaniline In Medaka (Oryzias Latipes), Steven P. Bradbury, Julia M. Dady, Patrick N. Fitzsimmons, Michelle M. Voit, Dean E, Hammermeister, Russell J. Erickson

Steven P. Bradbury

The in vivo toxicokinetics and in vitro hepatic microsomal metabolism of (14C)aniline and (14C)4-chloroaniline in medaka (Oryzias latipes) were investigated to provide a basis upon which to interpret the toxicological responses of small aquarium fish to aniline derivatives. During static aqueous exposures of up to 320 min, parent equivalents failed to reach steady state and results from depuration studies clearly demonstrated biphasic elimination. Due to low elimination rates, 40 to 20% of absorbed aniline and 4-chloroaniline doses, respectively, remained within the fish through 330 min postexposure. Based on an analysis of excreted metabolites, N-acetylation was the dominant route of in …

A Non-Invasive Neurotoxicity Assay Using Larval Medaka, Steven P. Bradbury, Dave Featherstone, Charles D. Drewes, Joel R. Coats

Steven P. Bradbury

We present a method for non-invasive electrophysiological analysis of rapid escape responses in intact, freely behaving larval medaka (Oryzias latipes) before and after short-term exposure to environmental toxicants. Recordings are obtained as a larval medaka swims in a small chamber of water above pairs of recording electrodes etched onto a printed circuit board. When the chamber is briefly vibrated by a sinusoidal pulse from a speaker attached to the grid, a stereotyped Mauthner cell-initiated escape response is evoked. The following parameters were quantified from recordings: 1) Mauthner axon conduction velocity, 2) delay between Mauthner axon spike and motoneuron spike in …